{"id":"https://openalex.org/W978576707","doi":null,"title":"Expression and clinical significance of P-gp,GST-\u03c0,TopoII in gastric carcinoma","display_name":"Expression and clinical significance of P-gp,GST-\u03c0,TopoII in gastric carcinoma","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W978576707","mag":"978576707"},"language":"en","primary_location":{"id":"mag:2366115577","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SXZL201009045.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Modern Oncology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075809074","display_name":"\u5434\u5b8f\u57f9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5434\u5b8f\u57f9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042204597","display_name":"\u674e\u4fca\u6d77","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u674e\u4fca\u6d77","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060349218","display_name":"\u5f20\u8fdc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f20\u8fdc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091748498","display_name":"\u6bb7\u559c\u6885","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6bb7\u559c\u6885","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014103302","display_name":"\u8d3e\u5175","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8d3e\u5175","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036395350","display_name":"\u5218\u5b8f\u6d9b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5218\u5b8f\u6d9b","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005017744","display_name":"\u6881\u82f1\u5e73","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6881\u82f1\u5e73","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"1788","last_page":"1791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glutathione-s-transferase-pi","display_name":"glutathione S-transferase pi","score":0.9190000295639038},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.9380000233650208},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mucinous-carcinoma","display_name":"mucinous carcinoma","score":0.7919999957084656},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3141288161277771}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2366115577","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SXZL201009045.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Modern Oncology","raw_type":null},{"id":"mag:978576707","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/83872X/201009/35238153.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306554777","display_name":"\u73b0\u4ee3\u80bf\u7624\u533b\u5b66","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u73b0\u4ee3\u80bf\u7624\u533b\u5b66","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W892974414","https://openalex.org/W645326864","https://openalex.org/W1015479562","https://openalex.org/W1183772805","https://openalex.org/W2253131464","https://openalex.org/W278706572","https://openalex.org/W757955574","https://openalex.org/W810819598","https://openalex.org/W1508182059","https://openalex.org/W922019986"],"abstract_inverted_index":{"\u76ee\u7684\uff1a\u63a2\u8ba8P-\u7cd6\u86cb\u767d\uff08P-gp\uff09,\u8c37\u80f1\u7518\u80bdS-\u8f6c\u79fb\u9176\u03c0\uff08GST-\u03c0\uff09\u53caDNA\u62d3\u6251\u5f02\u6784\u9176\uff08Topo\u2161\uff09\u5728\u80c3\u764c\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u53ca\u5176\u4e34\u5e8a\u610f\u4e49\u3002\u65b9\u6cd5\uff1a\u5e94\u7528\u514d\u75ab\u7ec4\u5316S-P\u6cd5\u8054\u5408\u68c0\u6d4bP-gp\u3001GST-\u03c0\u3001Topo\u2161\u572897\u4f8b\u80c3\u764c\u7ec4\u7ec7\u548c20\u4f8b\u6b63\u5e38\u80c3\u9ecf\u819c\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5,\u63a2\u8ba8\u5176\u4e0e\u80c3\u764c\u7684\u7ec4\u7ec7\u5b66\u7c7b\u578b\u3001\u6d78\u6da6\u7a0b\u5ea6\u3001\u6709\u65e0\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7684\u5173\u7cfb\u3002\u7ed3\u679c\uff1aP-gp\u3001GST-\u03c0\u5728\u80c3\u764c\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u9ad8\u4e8e\u6b63\u5e38\u80c3\u9ecf\u819c\u7ec4\u7ec7\uff08P\u30080.05\uff09,Topo\u2161\u5728\u80c3\u764c\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u4f4e\u4e8e\u6b63\u5e38\u80c3\u9ecf\u819c\u7ec4\u7ec7\uff08P\u30080.05\uff09\u3002P-gp\u3001GST-\u03c0\u5728\u4e2d\u9ad8\u5206\u5316\u817a\u764c\u4e2d\u7684\u8868\u8fbe\u9ad8\u4e8e\u4f4e\u5206\u5316\u817a\u764c,\u6709\u663e\u8457\u610f\u4e49\uff08P\u30080.05\uff09,Topo\u2161\u5728\u9ad8\u4e2d\u5206\u5316\u817a\u764c\u4e2d\u7684\u8868\u8fbe\u4f4e\u4e8e\u4f4e\u5206\u5316\u817a\u764c,\u6709\u663e\u8457\u610f\u4e49\uff08P\u30080.05\uff09\u3002P-gp\u3001GST-\u03c0\u3001Topo\u2161\u5728\u9ad8\u4e2d\u5206\u5316\u817a\u764c\u4e2d\u7684\u9633\u6027\u8868\u8fbe\u7387\u4e0e\u9ecf\u6db2\u764c\u76f8\u6bd4\u65e0\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P\u30090.05\uff09\u3002Topo\u2161\u5728\u9ecf\u6db2\u764c\u4e2d\u7684\u8868\u8fbe\u7387\u663e\u8457\u4f4e\u4e8e\u4f4e\u5206\u5316\u817a\u764c\uff08P\u30080.05\uff09\u3002P-gp\u3001GST-\u03c0\u3001Topo\u2161\u5728\u80bf\u7624\u6d78\u6da6\u7a0b\u5ea6\u4e0a\u65e0\u663e\u8457\u5dee\u522b\uff08P\u30090.05\uff09\u3002P-gp\u3001GST-\u03c0\u5728\u6709\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7ec4\u7684\u8868\u8fbe\u7387\u9ad8\u4e8e\u65e0\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7ec4,\u6709\u663e\u8457\u610f\u4e49\uff08P\u30080.05\uff09;Topo\u2161\u5728\u6709\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7ec4\u7684\u8868\u8fbe\u7387\u4f4e\u4e8e\u65e0\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7ec4,\u4f46\u7edf\u8ba1\u5b66\u4e0a\u65e0\u663e\u8457\u610f\u4e49\uff08P\u30090.05\uff09\u3002\u7ed3\u8bba\uff1aP-gp\u3001GST-\u03c0\u3001Topo\u2161\u5747\u5728\u80c3\u764c\u539f\u53d1\u6027\u591a\u836f\u8010\u836f\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u5b83\u4eec\u5728\u80c3\u764c\u4e2d\u7684\u8868\u8fbe\u4e0e\u80bf\u7624\u6d78\u6da6\u6df1\u5ea6\u65e0\u5173,\u4e0e\u7ec4\u7ec7\u5b66\u7c7b\u578b\u3001\u6709\u65e0\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u6709\u5173\u3002\u8054\u5408\u68c0\u6d4bP-gp\u3001GST-\u03c0\u3001Topo\u2161\u5bf9\u4e8e\u80c3\u764c\u5236\u5b9a\u4e2a\u4f53\u5316\u7684\u5316\u7597\u65b9\u6848\u6709\u6307\u5bfc\u610f\u4e49\u3002":[0]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}