{"id":"https://openalex.org/W978370604","doi":"https://doi.org/10.1097/sap.0000000000000595","title":"The Effects of Hydrogen Sulfide on Adipocyte Viability in Human Adipocyte and Adipocyte-Derived Mesenchymal Stem Cell Cultures Under Ischemic Conditions","display_name":"The Effects of Hydrogen Sulfide on Adipocyte Viability in Human Adipocyte and Adipocyte-Derived Mesenchymal Stem Cell Cultures Under Ischemic Conditions","publication_year":2015,"publication_date":"2015-07-24","ids":{"openalex":"https://openalex.org/W978370604","doi":"https://doi.org/10.1097/sap.0000000000000595","mag":"978370604","pmid":"https://pubmed.ncbi.nlm.nih.gov/26207556"},"language":"en","primary_location":{"id":"doi:10.1097/sap.0000000000000595","doi":"https://doi.org/10.1097/sap.0000000000000595","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0000000000000595","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046656200","display_name":"Anda\u00e7 Aykan","orcid":"https://orcid.org/0000-0002-0309-2508","observed_orcids":["https://orcid.org/0000-0002-0309-2508"]},"institutions":[{"id":"https://openalex.org/I2799953620","display_name":"Turkish Armed Forces","ror":"https://ror.org/015dfn538","country_code":"TR","type":"government","lineage":["https://openalex.org/I2799953620"]},{"id":"https://openalex.org/I4210090244","display_name":"G\u00fclhane Asker\u00ee T\u0131p Akademisi","ror":"https://ror.org/00c8t7d47","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210090244","https://openalex.org/I4405258547"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Andac Aykan","raw_affiliation_strings":["From the *Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey","Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey","institution_ids":["https://openalex.org/I2799953620","https://openalex.org/I4210090244"]},{"raw_affiliation_string":"Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey","institution_ids":["https://openalex.org/I2799953620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101478313","display_name":"Serdar \u00d6zt\u00fcrk","orcid":"https://orcid.org/0000-0001-8356-9224","observed_orcids":["https://orcid.org/0000-0001-8356-9224"]},"institutions":[{"id":"https://openalex.org/I2799953620","display_name":"Turkish Armed Forces","ror":"https://ror.org/015dfn538","country_code":"TR","type":"government","lineage":["https://openalex.org/I2799953620"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Serdar Ozturk","raw_affiliation_strings":["Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey","institution_ids":["https://openalex.org/I2799953620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113492847","display_name":"\u0130smail \u015eahin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799953620","display_name":"Turkish Armed Forces","ror":"https://ror.org/015dfn538","country_code":"TR","type":"government","lineage":["https://openalex.org/I2799953620"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ismail Sahin","raw_affiliation_strings":["Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey","institution_ids":["https://openalex.org/I2799953620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079748613","display_name":"Ferit Avcu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferit Avcu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048631698","display_name":"Rah\u015fan Il\u0131k\u00e7\u0131 Sa\u011fkan","orcid":"https://orcid.org/0000-0003-3844-6158","observed_orcids":["https://orcid.org/0000-0003-3844-6158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rahsan Ilik\u00e7i Sagkan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110353129","display_name":"Sel\u00e7uk I\u015f\u0131k","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799953620","display_name":"Turkish Armed Forces","ror":"https://ror.org/015dfn538","country_code":"TR","type":"government","lineage":["https://openalex.org/I2799953620"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Selcuk Isik","raw_affiliation_strings":["Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Reconstructive Surgery, \u2020Department of Hematology, and \u2021Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy, Etlik, Ankara, Turkey","institution_ids":["https://openalex.org/I2799953620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046656200","https://openalex.org/A5101478313","https://openalex.org/A5110353129","https://openalex.org/A5113492847"],"corresponding_institution_ids":["https://openalex.org/I2799953620","https://openalex.org/I4210090244"],"apc_list":null,"apc_paid":null,"fwci":0.5871,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.58475742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"75","issue":"6","first_page":"657","last_page":"665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.08789999783039093,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":1.0},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.6949999928474426},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.7910000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.718999981880188},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8169999718666077},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.925000011920929},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9380000233650208},{"id":"https://openalex.org/keywords/anti-apoptotic-gene-expression","display_name":"anti-apoptotic gene expression","score":0.7570000290870667},{"id":"https://openalex.org/keywords/sodium-hydrosulfide","display_name":"sodium hydrosulfide","score":0.640999972820282},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.5479999780654907},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7956624031066895},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.7324130535125732},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6295106410980225},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4553322494029999},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4375768303871155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4015581011772156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3601197600364685},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34981513023376465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3400364816188812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2913735508918762},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006862","descriptor_name":"Hydrogen Sulfide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006862","descriptor_name":"Hydrogen Sulfide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050151","descriptor_name":"Subcutaneous Fat","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D050151","descriptor_name":"Subcutaneous Fat","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050151","descriptor_name":"Subcutaneous Fat","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/sap.0000000000000595","doi":"https://doi.org/10.1097/sap.0000000000000595","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0000000000000595","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},{"id":"pmid:26207556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26207556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of plastic surgery","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1487516961","https://openalex.org/W1881390322","https://openalex.org/W1967242279","https://openalex.org/W1982699743","https://openalex.org/W1983761772","https://openalex.org/W1984670498","https://openalex.org/W1989548393","https://openalex.org/W1992451903","https://openalex.org/W1992996571","https://openalex.org/W1996849473","https://openalex.org/W2000314257","https://openalex.org/W2002362842","https://openalex.org/W2011596225","https://openalex.org/W2016223116","https://openalex.org/W2022060385","https://openalex.org/W2033203667","https://openalex.org/W2033484101","https://openalex.org/W2039648389","https://openalex.org/W2043573281","https://openalex.org/W2049220790","https://openalex.org/W2064154659","https://openalex.org/W2087405813","https://openalex.org/W2091482008","https://openalex.org/W2094983394","https://openalex.org/W2098018562","https://openalex.org/W2106717149","https://openalex.org/W2107312159","https://openalex.org/W2107838881","https://openalex.org/W2118544754","https://openalex.org/W2137002327","https://openalex.org/W2141610173","https://openalex.org/W2160081886","https://openalex.org/W2164947880","https://openalex.org/W4248555545"],"related_works":["https://openalex.org/W2556869883","https://openalex.org/W2016625731","https://openalex.org/W2994639593","https://openalex.org/W3029877153","https://openalex.org/W2367692777","https://openalex.org/W2947341299","https://openalex.org/W7097768023","https://openalex.org/W2034412869","https://openalex.org/W2114408110","https://openalex.org/W2040949733"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"evaluated":[3,120],"the":[4,47,84,98,112,115,122,127,194,238],"in":[5,103,157,162,189],"vitro":[6],"effects":[7],"of":[8,21,240],"hydrogen":[9,73,79,88,177,219],"sulfide":[10,74,80,89,178,220],"on":[11,193,225],"adipocyte":[12,53,64,196],"survival":[13],"under":[14],"ischemic":[15,217],"conditions":[16],"and":[17,50,62,95,134,137,147,173,209,229,232],"explored":[18],"possible":[19],"mechanisms":[20],"its":[22],"apoptotic":[23,144],"process.":[24],"METHODS:":[25],"The":[26,57],"mesenchymal":[27,41,59,163,226],"stem":[28,42,60,164,227],"cell":[29,61,99,116,165,201],"culture":[30,54,117,202],"was":[31,55,75,187,207,213],"prepared":[32],"from":[33],"a":[34,51,78,183,222],"human":[35],"subcutaneous":[36],"adipose":[37],"tissue":[38],"sample.":[39],"Adipose-derived":[40],"cells":[43,228],"were":[44,66,101,119,160],"differentiated":[45],"into":[46,69],"adipogenic":[48],"direction,":[49],"mature":[52,63,195,230],"obtained.":[56],"adipose-derived":[58],"cultures":[65,100,197],"both":[67,200],"divided":[68],"6":[70],"groups.":[71],"Sodium":[72],"used":[76],"as":[77],"donor.":[81],"After":[82,111],"treating":[83],"groups":[85,118,166],"with":[86,121,168],"sodium":[87,176],"(0,":[90,171],"0.1,":[91],"1,":[92,172],"10,":[93],"100,":[94],"1000":[96],"\u03bcM),":[97],"incubated":[102],"1%":[104],"oxygen":[105],"at":[106],"37\u00b0C":[107],"for":[108,126,132,143],"24":[109],"hours.":[110],"ischemia":[113],"period,":[114],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[123],"bromide":[124],"test":[125],"proliferation/cytotoxicity":[128],"rates,":[129,136],"flow":[130],"cytometry":[131],"apoptosis":[133,191],"necrosis":[135],"reverse":[138],"transcriptase":[139],"polymerase":[140],"chain":[141],"reaction":[142],"(Bax,":[145],"Caspase-3)":[146],"antiapoptotic":[148,241],"(Bcl-2)":[149],"gene":[150,205,211,242],"expression":[151,206,212],"levels.":[152],"RESULTS:":[153],"Statistically":[154],"significant":[155,185],"increases":[156],"proliferation":[158],"rates":[159],"found":[161,188],"treated":[167],"low":[169],"dose":[170],"1":[174],"\u03bcM)":[175],"(P<0.05).":[179,198],"For":[180],"each":[181],"dose,":[182],"statistically":[184],"decrease":[186],"late":[190],"levels":[192],"In":[199],"groups,":[203],"Bcl-2":[204],"increased":[208],"Caspase-3":[210],"decreased.":[214],"CONCLUSIONS:":[215],"Under":[216],"conditions,":[218],"has":[221],"protective":[223],"effect":[224,234],"adipocytes,":[231],"this":[233],"is":[235],"mediated":[236],"by":[237],"elevation":[239],"expression.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}