{"id":"https://openalex.org/W97805483","doi":"https://doi.org/10.5055/jom.2007.0015","title":"Efficacy and safety of 12 weeks of osteoarthritic pain therapy with once-daily tramadol (Tramadol Contramid\u00ae OAD)","display_name":"Efficacy and safety of 12 weeks of osteoarthritic pain therapy with once-daily tramadol (Tramadol Contramid\u00ae OAD)","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W97805483","doi":"https://doi.org/10.5055/jom.2007.0015","mag":"97805483","pmid":"https://pubmed.ncbi.nlm.nih.gov/18181382"},"language":"en","primary_location":{"id":"doi:10.5055/jom.2007.0015","doi":"https://doi.org/10.5055/jom.2007.0015","is_oa":false,"landing_page_url":"https://doi.org/10.5055/jom.2007.0015","pdf_url":null,"source":{"id":"https://openalex.org/S2764961062","display_name":"Journal of Opioid Management","issn_l":"1551-7489","issn":["1551-7489","2375-0146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Opioid Management","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070832918","display_name":"Ritchard L. Fishman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166265","display_name":"Remington-Davis Clinical Research","ror":"https://ror.org/05psy1s28","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210166265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritchard L. Fishman, MD","raw_affiliation_strings":["Remington Davis, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Remington Davis, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I4210166265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111392958","display_name":"Charles James Kistler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles James Kistler, DO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080998753","display_name":"Michael T. Ellerbusch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael T. Ellerbusch, MD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113469701","display_name":"R. Aparicio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul Tomas Aparicio, MD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114260250","display_name":"Sharad S. Swami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharad S. Swami, MD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047200448","display_name":"Mark E. Shirley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark E. Shirley, DO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112773656","display_name":"Adesh K. Jain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adesh K. Jain, MD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114260251","display_name":"MSc Louise Fortier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louise Fortier, MSc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108378462","display_name":"BScN Sybil Robertson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sybil Robertson, BScN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046540684","display_name":"Sylvie Bouchard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvie Bouchard, MD, PhD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0186,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.89421838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"5","first_page":"273","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.2736999988555908,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tramadol","display_name":"tramadol","score":0.9679999947547913},{"id":"https://openalex.org/keywords/once-daily-formulation","display_name":"once-daily formulation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/osteoarthritis-pain","display_name":"osteoarthritis pain","score":0.7269999980926514},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/analgesic-efficacy","display_name":"analgesic efficacy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6110000014305115},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9129999876022339},{"id":"https://openalex.org/keywords/womac-pain-score","display_name":"WOMAC pain score","score":0.6600000262260437},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.5220000147819519},{"id":"https://openalex.org/keywords/extended-release-formulation","display_name":"sustained-release formulation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.7110000252723694},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.578000009059906},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.5460000038146973},{"id":"https://openalex.org/keywords/sleepiness","display_name":"sleepiness","score":0.8730000257492065},{"id":"https://openalex.org/keywords/vomiting","display_name":"vomiting","score":0.6940000057220459},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.41499999165534973},{"id":"https://openalex.org/keywords/responder-analysis","display_name":"responder analysis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/fixed-dose-regimen","display_name":"fixed-dose regimen","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9408090710639954},{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.9180270433425903},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7860884666442871},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6586651802062988},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5948190689086914},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.5842498540878296},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.574020266532898},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5606597661972046},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5276155471801758},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.43024110794067383},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.376817524433136},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2656930685043335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22618618607521057},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.5055/jom.2007.0015","doi":"https://doi.org/10.5055/jom.2007.0015","is_oa":false,"landing_page_url":"https://doi.org/10.5055/jom.2007.0015","pdf_url":null,"source":{"id":"https://openalex.org/S2764961062","display_name":"Journal of Opioid Management","issn_l":"1551-7489","issn":["1551-7489","2375-0146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Opioid Management","raw_type":"journal-article"},{"id":"pmid:18181382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18181382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of opioid management","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030311535","https://openalex.org/W1941673341","https://openalex.org/W2042443179","https://openalex.org/W2045844949","https://openalex.org/W2055728946","https://openalex.org/W1989188451","https://openalex.org/W2047076695","https://openalex.org/W150253397","https://openalex.org/W4251011716","https://openalex.org/W2376963905"],"abstract_inverted_index":{"This":[0,317],"placebo-controlled":[1],"study":[2,318],"examined":[3],"the":[4,39,69,82,95,142,151,213,219,222,242,301,320,341],"analgesic":[5],"efficacy,":[6],"safety,":[7],"and":[8,21,26,73,94,98,103,159,177,189,203,270,285,298,300,322,330],"clinical":[9],"benefit":[10],"of":[11,38,86,112,123,147,180,221,244,287,292,309,315,324,340],"Tramadol":[12,53,184,225,260,325],"Contramid":[13,54,185,226,261,326],"OAD,":[14],"a":[15,127,195,237,248],"once-daily":[16],"formulation":[17],"with":[18,29,81,224,229,279,335],"both":[19,259],"immediate-":[20],"extended-release":[22],"components.":[23],"Five":[24],"hundred":[25],"fifty-two":[27],"patients":[28,124,181,245,310,334],"moderate":[30,306,336],"to":[31,35,52,62,68,110,183,218,305,344],"severe":[32,338],"pain":[33,135,215,256,339],"due":[34,343],"osteoarthritis":[36],"(OA)":[37],"knee":[40,342],"were":[41,290],"randomized":[42,71,182],"into":[43],"this":[44],"multicenter,":[45],"double-blind,":[46],"parallel":[47],"arm":[48],"study.":[49],"After":[50],"randomization":[51],"OAD":[55,186,227,262,327],"100,":[56],"200,":[57],"or":[58,61,164,171,337],"300":[59,160,190,271,331],"mg,":[60,191],"placebo,":[63],"patients'":[64],"dose":[65,72],"was":[66,79,120,155,168,194,303],"titrated":[67],"fixed":[70],"maintained":[74],"for":[75,231,258],"12":[76],"weeks.":[77],"Efficacy":[78],"evaluated":[80],"Patients'":[83],"Global":[84,145],"Rating":[85,146],"Pain":[87,102,148],"Relief":[88,149],"(median":[89],"ratings":[90],"at":[91,150],"maintenance":[92,153],"visits),":[93],"Western":[96],"Ontario":[97],"McMaster":[99],"University":[100],"(WOMAC)":[101],"Physical":[104],"Function":[105],"subscales":[106],"(percent":[107],"difference,":[108],"baseline":[109,133,254],"end":[111,220],"study)":[113,223],"as":[114],"coprimary":[115],"endpoints.":[116],"A":[117],"responder":[118,234],"analysis":[119,235],"conducted":[121],"(percentage":[122],"who":[125,246,311],"achieved":[126,247],"30":[128,249],"percent":[129,176,179,197,205,250],"improvement":[130,211,251],"on":[131,141,212],"their":[132,253],"WOMAC":[134,214,255],"score).":[136],"The":[137,233,283],"difference":[138,240],"from":[139],"placebo":[140,280],"median":[143],"Patient":[144],"four":[152],"visits":[154],"statistically":[156,238],"significant":[157,239],"(200":[158],"mg:":[161],"p":[162,200,208,267,275],"<":[163],"=":[165,201,209,268,276],"0.001).":[166],"Treatment":[167],"rated":[169],"effective":[170,173],"very":[172],"by":[174],"75":[175],"80":[178],"200":[187,263,328],"mg":[188,264,272,329,332],"respectively.":[192],"There":[193],"46":[196],"(300-mg":[198],"dose;":[199,207],"0.016)":[202],"43":[204],"(200-mg":[206],"0.05)":[210],"score":[216,257],"(baseline":[217],"compared":[228,278],"32percent":[230],"placebo.":[232],"demonstrated":[236],"in":[241,252,307,333],"percentage":[243],"(65":[265,273],"percent;":[266,274],"0.0095)":[269],"0.0104)":[277],"(50":[281],"percent).":[282],"type":[284],"incidence":[286],"adverse":[288],"events":[289],"typical":[291],"tramadol":[293],"(nausea,":[294],"dizziness/vertigo,":[295],"vomiting,":[296],"somnolence,":[297],"constipation)":[299],"intensity":[302],"mild":[304],"87percent":[308],"experienced":[312],"them":[313],"regardless":[314],"dose.":[316],"shows":[319],"efficacy":[321],"safety":[323],"OA.":[345]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}