{"id":"https://openalex.org/W97763337","doi":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","title":"Okadaic acid, an inhibitor of protein phosphatase 1 in Paramecium, causes sustained Ca2(+)\u2010dependent backward swimming in response to depolarizing stimuli.","display_name":"Okadaic acid, an inhibitor of protein phosphatase 1 in Paramecium, causes sustained Ca2(+)\u2010dependent backward swimming in response to depolarizing stimuli.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W97763337","doi":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","mag":"97763337","pmid":"https://pubmed.ncbi.nlm.nih.gov/2155778","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/551721"},"language":"en","primary_location":{"id":"doi:10.1002/j.1460-2075.1990.tb08160.x","doi":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1460-2075.1990.tb08160.x","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1460-2075.1990.tb08160.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081538063","display_name":"Susanne Klumpp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Klumpp","raw_affiliation_strings":["Pharmazeutisches Institut, Universitat T\u00fcbingen, FRG","Pharmazeutisches Institut, Universit\u00e4t T\u00fcbingen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmazeutisches Institut, Universitat T\u00fcbingen, FRG","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Pharmazeutisches Institut, Universit\u00e4t T\u00fcbingen, FRG","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010890113","display_name":"Philip Cohen","orcid":"https://orcid.org/0000-0001-7632-9492","observed_orcids":["https://orcid.org/0000-0001-7632-9492"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Cohen","raw_affiliation_strings":["Pharmazeutisches Institut, Universitat T\u00fcbingen, FRG","Pharmazeutisches Institut, Universit\u00e4t T\u00fcbingen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmazeutisches Institut, Universitat T\u00fcbingen, FRG","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Pharmazeutisches Institut, Universit\u00e4t T\u00fcbingen, FRG","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004439886","display_name":"Joachim Erdmann Schultz","orcid":"https://orcid.org/0000-0002-1985-4853","observed_orcids":["https://orcid.org/0000-0002-1985-4853"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J.E. Schultz","raw_affiliation_strings":["Pharmazeutisches Institut, Universitat T\u00fcbingen, FRG","Pharmazeutisches Institut, Universit\u00e4t T\u00fcbingen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmazeutisches Institut, Universitat T\u00fcbingen, FRG","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Pharmazeutisches Institut, Universit\u00e4t T\u00fcbingen, FRG","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":3.8273,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.94386536,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"9","issue":"3","first_page":"685","last_page":"689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/paramecium","display_name":"Paramecium","score":0.9539999961853027},{"id":"https://openalex.org/keywords/backward-swimming","display_name":"backward swimming","score":0.984000027179718},{"id":"https://openalex.org/keywords/calcium-channel-inactivation","display_name":"calcium channel inactivation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/depolarization","display_name":"depolarization","score":0.7310000061988831},{"id":"https://openalex.org/keywords/potassium-induced-depolarization","display_name":"potassium depolarization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/calcium-chelation","display_name":"calcium chelation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ciliary-membrane","display_name":"ciliary membrane","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.9613109827041626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.916286826133728},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.8029454350471497},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6711688041687012},{"id":"https://openalex.org/C2780536333","wikidata":"https://www.wikidata.org/wiki/Q199456","display_name":"Paramecium","level":2,"score":0.6706626415252686},{"id":"https://openalex.org/C2779408958","wikidata":"https://www.wikidata.org/wiki/Q7251492","display_name":"Protein phosphatase 1","level":4,"score":0.4614270031452179},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41050195693969727},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3617103695869446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33884716033935547},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.21020513772964478}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004988","descriptor_name":"Ethers, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010247","descriptor_name":"Paramecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010247","descriptor_name":"Paramecium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019319","descriptor_name":"Okadaic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/j.1460-2075.1990.tb08160.x","doi":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1460-2075.1990.tb08160.x","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmid:2155778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2155778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/22f94262-2458-4ee8-8dea-f9fd36b19546","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/22f94262-2458-4ee8-8dea-f9fd36b19546","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klumpp, S, Cohen, P & Schultz, J E 1990, 'Okadaic acid, an inhibitor of protein phosphatase 1 in Paramecium, causes sustained Ca2+-dependent backward swimming in response to depolarizing stimuli', EMBO Journal, vol. 9, no. 3, pp. 685-689.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:551721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC551721/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/j.1460-2075.1990.tb08160.x","doi":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1990.tb08160.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1460-2075.1990.tb08160.x","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310838","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W97763337.pdf","grobid_xml":"https://content.openalex.org/works/W97763337.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W104283729","https://openalex.org/W140944189","https://openalex.org/W969971711","https://openalex.org/W1581101118","https://openalex.org/W1749352888","https://openalex.org/W1930201122","https://openalex.org/W1967299600","https://openalex.org/W1973454785","https://openalex.org/W1983918349","https://openalex.org/W1984434545","https://openalex.org/W1984972991","https://openalex.org/W1992717591","https://openalex.org/W1997423041","https://openalex.org/W2004691837","https://openalex.org/W2009884429","https://openalex.org/W2019638143","https://openalex.org/W2028642327","https://openalex.org/W2034600310","https://openalex.org/W2045968205","https://openalex.org/W2047971331","https://openalex.org/W2048721312","https://openalex.org/W2054678898","https://openalex.org/W2058949874","https://openalex.org/W2081418915","https://openalex.org/W2175515094","https://openalex.org/W2178456244","https://openalex.org/W2409348129","https://openalex.org/W2901833066","https://openalex.org/W6600669096","https://openalex.org/W6814005818"],"related_works":["https://openalex.org/W2005845755","https://openalex.org/W2032147837","https://openalex.org/W2528896322","https://openalex.org/W2089619207","https://openalex.org/W2046788323","https://openalex.org/W2027637814","https://openalex.org/W2526013069","https://openalex.org/W2046007129","https://openalex.org/W2408846881","https://openalex.org/W2059561892"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}