{"id":"https://openalex.org/W9773025","doi":null,"title":"Potential Roles of Peroxidases in Caenorhabditis Elegans Innate Immunity","display_name":"Potential Roles of Peroxidases in Caenorhabditis Elegans Innate Immunity","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W9773025","mag":"9773025"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1523","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/483","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/483","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088369508","display_name":"George R Tiller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"George R Tiller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088369508"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxidase","display_name":"peroxidase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9610000252723694},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8320000171661377},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.7059999704360962},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/subcutaneous-tissue","display_name":"subcutaneous tissue","score":0.9300000071525574},{"id":"https://openalex.org/keywords/host-pathogen-resistance","display_name":"host-pathogen resistance","score":0.4970000088214874},{"id":"https://openalex.org/keywords/dual-oxidase","display_name":"dual oxidase","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8212099075317383},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8127119541168213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5686041116714478},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5632798671722412},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.43292173743247986},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2672807574272156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1519785225391388},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15047398209571838},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09854426980018616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07901328802108765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07524701952934265}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1523","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/483","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/483","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:9773025","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1523&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1523","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/483","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/483","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W9773025.pdf","grobid_xml":"https://content.openalex.org/works/W9773025.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W97463538","https://openalex.org/W191693931","https://openalex.org/W332762500","https://openalex.org/W1486450190","https://openalex.org/W1509638340","https://openalex.org/W1527453674","https://openalex.org/W1528203877","https://openalex.org/W1540415144","https://openalex.org/W1563715672","https://openalex.org/W1585390661","https://openalex.org/W1591325634","https://openalex.org/W1654353550","https://openalex.org/W1837406199","https://openalex.org/W1850582425","https://openalex.org/W1944127002","https://openalex.org/W1967746062","https://openalex.org/W1969157447","https://openalex.org/W1970680658","https://openalex.org/W1973116767","https://openalex.org/W1973523054","https://openalex.org/W1973733030","https://openalex.org/W1975434365","https://openalex.org/W1976298790","https://openalex.org/W1978046264","https://openalex.org/W1978565972","https://openalex.org/W1983761290","https://openalex.org/W1988376786","https://openalex.org/W1992170226","https://openalex.org/W1993312333","https://openalex.org/W1998653602","https://openalex.org/W1998662190","https://openalex.org/W2000179381","https://openalex.org/W2000754365","https://openalex.org/W2005222994","https://openalex.org/W2007286794","https://openalex.org/W2007358741","https://openalex.org/W2008160172","https://openalex.org/W2012104592","https://openalex.org/W2013259203","https://openalex.org/W2013977400","https://openalex.org/W2018359498","https://openalex.org/W2018984214","https://openalex.org/W2019165286","https://openalex.org/W2020400086","https://openalex.org/W2021171040","https://openalex.org/W2022195195","https://openalex.org/W2024576544","https://openalex.org/W2025769245","https://openalex.org/W2026932718","https://openalex.org/W2030676914","https://openalex.org/W2031576549","https://openalex.org/W2032358444","https://openalex.org/W2034790718","https://openalex.org/W2036174322","https://openalex.org/W2036897009","https://openalex.org/W2036931975","https://openalex.org/W2036953322","https://openalex.org/W2037854342","https://openalex.org/W2038492783","https://openalex.org/W2039217550","https://openalex.org/W2039452697","https://openalex.org/W2040131810","https://openalex.org/W2040252933","https://openalex.org/W2040657632","https://openalex.org/W2042416903","https://openalex.org/W2046835799","https://openalex.org/W2049166422","https://openalex.org/W2052471206","https://openalex.org/W2053095874","https://openalex.org/W2054858711","https://openalex.org/W2055688463","https://openalex.org/W2056054105","https://openalex.org/W2056952563","https://openalex.org/W2059149560","https://openalex.org/W2059555945","https://openalex.org/W2060465660","https://openalex.org/W2062946341","https://openalex.org/W2063596886","https://openalex.org/W2064647551","https://openalex.org/W2066657154","https://openalex.org/W2068189492","https://openalex.org/W2068861782","https://openalex.org/W2069463594","https://openalex.org/W2070140841","https://openalex.org/W2072724034","https://openalex.org/W2073241455","https://openalex.org/W2075154240","https://openalex.org/W2078654865","https://openalex.org/W2079639127","https://openalex.org/W2080506450","https://openalex.org/W2084630938","https://openalex.org/W2085034589","https://openalex.org/W2085100495","https://openalex.org/W2085864038","https://openalex.org/W2089101495","https://openalex.org/W2089887078","https://openalex.org/W2091613063","https://openalex.org/W2095508691","https://openalex.org/W2095835743","https://openalex.org/W2095957977","https://openalex.org/W2098070256","https://openalex.org/W2098567793","https://openalex.org/W2100186836","https://openalex.org/W2100925647","https://openalex.org/W2101692904","https://openalex.org/W2101745219","https://openalex.org/W2102476539","https://openalex.org/W2104818214","https://openalex.org/W2108235369","https://openalex.org/W2112132467","https://openalex.org/W2115755375","https://openalex.org/W2115948988","https://openalex.org/W2122163057","https://openalex.org/W2128491398","https://openalex.org/W2131829197","https://openalex.org/W2134902158","https://openalex.org/W2136261717","https://openalex.org/W2137131296","https://openalex.org/W2137590150","https://openalex.org/W2141368302","https://openalex.org/W2141663828","https://openalex.org/W2144590706","https://openalex.org/W2148019518","https://openalex.org/W2150591923","https://openalex.org/W2151034892","https://openalex.org/W2152008594","https://openalex.org/W2152221103","https://openalex.org/W2153047806","https://openalex.org/W2154084546","https://openalex.org/W2155538799","https://openalex.org/W2157429169","https://openalex.org/W2160616807","https://openalex.org/W2161387562","https://openalex.org/W2161997291","https://openalex.org/W2162537991","https://openalex.org/W2164479709","https://openalex.org/W2165496886","https://openalex.org/W2170124733","https://openalex.org/W2172117086","https://openalex.org/W2292720972","https://openalex.org/W2327543792","https://openalex.org/W2340885834","https://openalex.org/W2799244951","https://openalex.org/W7075713245"],"related_works":["https://openalex.org/W2054858711","https://openalex.org/W2172117086","https://openalex.org/W2946808269","https://openalex.org/W2046835799","https://openalex.org/W2135419313","https://openalex.org/W3132189171","https://openalex.org/W2911777499","https://openalex.org/W7097654987","https://openalex.org/W2085305359","https://openalex.org/W3213753843"],"abstract_inverted_index":{"The":[0,250],"production":[1],"of":[2,32,65,117,227,243],"ROS":[3,25,41],"(reactive":[4],"oxygen":[5],"species)":[6],"in":[7,68,72,81,95,121,128,169,188,209,220,238,277],"response":[8,16,132,152,173,221],"to":[9,23,61,74,100,133,148,155,197,222,271],"pathogen":[10],"detection":[11],"is":[12,18,43,48,89,98,167,185,206],"a":[13,40,69,79,91,101,115,231,235,265],"rapid,":[14],"nonspecific":[15],"that":[17,165,183,204,213],"evolutionarily":[19],"conserved":[20],"from":[21],"nematodes":[22],"humans.":[24],"serve":[26],"as":[27,230],"direct":[28],"and":[29,34,47,94,124,144,159,191,212,258],"indirect":[30],"effectors":[31],"innate":[33],"adaptive":[35],"immunity.":[36],"In":[37,136,225],"Caenorhabditis":[38],"elegans,":[39],"burst":[42,274],"observed":[44,203,234,254],"during":[45,174,256],"infection":[46,257],"mediated":[49],"by":[50,87,105,200,248],"the":[51,63,82,129,149,170,189,210,244,272],"dual":[52],"oxidase":[53],"BLI-3,":[54],"which":[55],"produces":[56],"H2O2.":[57],"RNAi":[58,158],"(RNA":[59],"interference)":[60],"reduce":[62],"amount":[64],"BLI-3":[66,77],"results":[67],"significant":[70,236],"increase":[71,237],"susceptibility":[73],"pathogens,":[75],"suggesting":[76],"has":[78],"role":[80],"immune":[83,131,151,172],"response.":[84],"However,":[85],"H2O2":[86,239,252],"itself":[88],"not":[90,218],"potent":[92,103],"antimicrobial":[93],"other":[96],"systems":[97,275],"converted":[99],"more":[102],"oxidant":[104],"an":[106],"affiliated":[107],"peroxidase.":[108],"During":[109],"my":[110],"work,":[111],"I":[112,138,163,181,202,233,262],"have":[113,263],"characterized":[114,264],"group":[116],"previously":[118],"unstudied":[119],"peroxidases":[120],"C.":[122],"elegans":[123],"determined":[125,164,182],"their":[126],"involvement":[127],"host":[130,150,171],"Enterococcus":[134],"faecalis.":[135,224],"particular,":[137],"focused":[139],"on":[140],"SKPO-1":[141,166,184,205,228],"(ShkT-containing":[142],"peroxidase)":[143],"how":[145],"it":[146],"contributes":[147],"with":[153],"respect":[154],"BLI-3.":[156],"By":[157,178],"skpo-1":[160],"mutant":[161],"analysis,":[162],"involved":[168],"E.":[175,223],"faecalis":[176],"infection.":[177,198],"tissue-specific":[179],"RNAi,":[180],"functionally":[186],"active":[187],"hypodermis":[190,211],"required":[192],"for":[193],"wild":[194],"type":[195],"resistance":[196],"Additionally,":[199],"immunohistochemistry,":[201],"only":[207,255],"expressed":[208],"its":[214],"protein":[215],"levels":[216,240],"do":[217],"change":[219],"support":[226],"acting":[229],"peroxidase,":[232],"when":[241],"expression":[242],"gene":[245],"was":[246,253,259],"reduced":[247],"RNAi.":[249],"increased":[251],"BLI-3-dependent.":[260],"Thus,":[261],"likely":[266],"BLI-3/SKPO-1":[267],"system,":[268],"potentially":[269],"similar":[270],"oxidative":[273],"present":[276],"higher":[278],"eukaryotes.":[279]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
