{"id":"https://openalex.org/W97720601","doi":null,"title":"Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture.","display_name":"Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture.","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W97720601","mag":"97720601","pmid":"https://pubmed.ncbi.nlm.nih.gov/7887447","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869182"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869182","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869182","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018294560","display_name":"Andreas Plettenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A Plettenberg","raw_affiliation_strings":["Department of Dermatology, University of Vienna Medical School, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Vienna Medical School, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072070320","display_name":"Claudia Ballaun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Ballaun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090090200","display_name":"Johannes Pammer","orcid":"https://orcid.org/0000-0002-9431-3221","observed_orcids":["https://orcid.org/0000-0002-9431-3221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Pammer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048907232","display_name":"Michael Mildner","orcid":"https://orcid.org/0000-0002-6892-925X","observed_orcids":["https://orcid.org/0000-0002-6892-925X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Mildner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015144738","display_name":"Dirk Strunk","orcid":"https://orcid.org/0000-0003-1810-867X","observed_orcids":["https://orcid.org/0000-0003-1810-867X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Strunk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080883696","display_name":"Wolfgang Weninger","orcid":"https://orcid.org/0000-0003-3133-8699","observed_orcids":["https://orcid.org/0000-0003-3133-8699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Weninger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035658428","display_name":"Erwin Tschachler","orcid":"https://orcid.org/0000-0002-0248-1798","observed_orcids":["https://orcid.org/0000-0002-0248-1798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Tschachler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7637,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.84954871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"146","issue":"3","first_page":"651","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.9470000267028809},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/epidermal-melanocytes","display_name":"epidermal melanocytes","score":0.777999997138977},{"id":"https://openalex.org/keywords/constitutive-expression","display_name":"constitutive expression","score":0.7950000166893005},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5350000262260437},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6399999856948853},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.6370000243186951},{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pigmented-skin-lesions","display_name":"pigmented skin lesions","score":0.7879999876022339},{"id":"https://openalex.org/keywords/normal-skin","display_name":"normal skin","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7459033727645874},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.666792631149292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6659046411514282},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.5421943664550781},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.529503345489502},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5228222608566284},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5057547092437744},{"id":"https://openalex.org/C2780291066","wikidata":"https://www.wikidata.org/wiki/Q1570264","display_name":"Merkel cell","level":4,"score":0.48160073161125183},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45941197872161865},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.44161680340766907},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3930600881576538},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3487107753753662},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3426583409309387},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31733888387680054},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16952857375144958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10090324282646179},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.08739155530929565},{"id":"https://openalex.org/C2778342957","wikidata":"https://www.wikidata.org/wiki/Q1711744","display_name":"Merkel cell carcinoma","level":3,"score":0.07004731893539429},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009506","descriptor_name":"Nevus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009506","descriptor_name":"Nevus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869182","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1869182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869182","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:7887447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7887447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:97720601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7887447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869182","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1522731616","https://openalex.org/W1554380543","https://openalex.org/W1572034293","https://openalex.org/W1649494421","https://openalex.org/W1966899632","https://openalex.org/W1970456090","https://openalex.org/W1970629830","https://openalex.org/W1971234510","https://openalex.org/W1973073454","https://openalex.org/W1981883990","https://openalex.org/W1984035854","https://openalex.org/W1984985329","https://openalex.org/W1990430117","https://openalex.org/W1995775226","https://openalex.org/W1997208169","https://openalex.org/W2002402507","https://openalex.org/W2005240718","https://openalex.org/W2009183764","https://openalex.org/W2015005447","https://openalex.org/W2022273331","https://openalex.org/W2025818427","https://openalex.org/W2036274324","https://openalex.org/W2037473273","https://openalex.org/W2048428832","https://openalex.org/W2057257609","https://openalex.org/W2063176993","https://openalex.org/W2067104437","https://openalex.org/W2082030057","https://openalex.org/W2083182916","https://openalex.org/W2089883223","https://openalex.org/W2092084302","https://openalex.org/W2094799975","https://openalex.org/W2134979684","https://openalex.org/W2316756341","https://openalex.org/W2332991185","https://openalex.org/W4229662680"],"related_works":["https://openalex.org/W1884310881","https://openalex.org/W2011531736","https://openalex.org/W2615440122","https://openalex.org/W4240987055","https://openalex.org/W2110864550","https://openalex.org/W4327634760","https://openalex.org/W1608936927","https://openalex.org/W1972325604","https://openalex.org/W1588533041","https://openalex.org/W2136120524"],"abstract_inverted_index":{"The":[0],"Bcl-2":[1,86,142,169,173],"proto-oncogene":[2],"regulates":[3],"cell":[4,13,121],"survival":[5],"by":[6,143],"antagonizing":[7],"events":[8],"that":[9,60,108,167,172],"lead":[10],"to":[11,19,48],"apoptotic":[12],"death":[14],"and":[15,30,73,78,99,119,149,171,178],"has":[16],"been":[17],"reported":[18],"be":[20],"expressed":[21,175],"in":[22,24,52,105,176,185],"situ":[23],"lymphoid":[25],"tissues,":[26],"glandular":[27],"epithelium,":[28],"neurons,":[29],"basal":[31,54],"epidermal":[32,55,89,111],"cells.":[33],"When":[34],"we":[35],"performed":[36],"immunostaining":[37],"on":[38],"cryostat":[39],"sections":[40],"of":[41,116,135,141,145,151,182],"normal":[42,159],"skin,":[43],"anti-Bcl-2":[44,131],"reactivity":[45],"was":[46],"confined":[47],"scattered":[49],"dendritic":[50],"cells":[51,63,80,90,166],"the":[53,61,94,130,164,183],"layer.":[56],"Double-staining":[57],"experiments":[58],"showed":[59],"Bcl-2+":[62,88],"were":[64,100],"positive":[65],"for":[66,70,84],"vimentin":[67],"but":[68],"negative":[69],"cytokeratins,":[71],"CD1a,":[72],"CD45":[74],"antigens,":[75],"excluding":[76],"keratinocytes":[77],"Langerhans":[79],"as":[81],"possible":[82],"candidates":[83],"constitutive":[85],"expression.":[87],"also":[91],"reacted":[92],"with":[93,129],"monoclonal":[95,132],"anti-melanocyte":[96],"antibody":[97],"NKI/beteb,":[98],"absent":[101],"from":[102],"lesional":[103],"skin":[104,184],"vitiligo,":[106],"confirming":[107],"they":[109],"represented":[110],"melanocytes.":[112],"Western":[113],"blot":[114],"analysis":[115],"cultured":[117],"melanocytes":[118,162],"melanoma":[120],"lines":[122],"revealed":[123,138],"a":[124],"26-kd":[125],"protein":[126],"specifically":[127],"reacting":[128],"antibody.":[133],"Immunostaining":[134],"pigmented":[136,180],"lesions":[137],"strong":[139],"expression":[140],"five":[144,146],"nevocellular":[147],"nevi":[148],"seven":[150,152],"melanomas.":[153],"Our":[154],"observations":[155],"demonstrate":[156],"that,":[157],"within":[158],"human":[160],"epidermis,":[161],"are":[163],"only":[165],"express":[168],"constitutively":[170],"is":[174],"benign":[177],"malignant":[179],"tumors":[181],"situ.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
