{"id":"https://openalex.org/W977093048","doi":null,"title":"[Effects of BMP-2 and FGF-2 on osteoblast differentiation of murine MSCs in vitro].","display_name":"[Effects of BMP-2 and FGF-2 on osteoblast differentiation of murine MSCs in vitro].","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W977093048","mag":"977093048","pmid":"https://pubmed.ncbi.nlm.nih.gov/18992192"},"language":"zh","primary_location":{"id":"pmid:18992192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18992192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085037356","display_name":"\u5f20\u4e3a\u897f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-xi Zhang","raw_affiliation_strings":["Department of Neurology, First Hospital of Sun Yat-sen University, Guangzhou 510080, China. weixizhang@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, First Hospital of Sun Yat-sen University, Guangzhou 510080, China. weixizhang@hotmail.com","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056081671","display_name":"\u9648\u677e\u6797","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Song-lin Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024099687","display_name":"\u59da\u6653\u9ece","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-li Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040245366","display_name":"\u5362\u9521\u6797","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi-lin Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081056706","display_name":"\u5468\u741b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059644861","display_name":"\u51b7\u96c1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Leng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084800489","display_name":"Xingming","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingming Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"11","first_page":"1062","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/osteogenic-induction","display_name":"osteogenic induction","score":0.8019999861717224},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.7620000243186951},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.906000018119812},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/collagen-1","display_name":"collagen-1","score":0.7749999761581421},{"id":"https://openalex.org/keywords/bone-marrow-cells","display_name":"bone marrow cells","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3710360527038574},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3360339403152466}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18992192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18992192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"Journal Article"},{"id":"mag:977093048","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/94263A/200811/28771312.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306556889","display_name":"\u7ec6\u80de\u4e0e\u5206\u5b50\u514d\u75ab\u5b66\u6742\u5fd7","issn_l":"1007-8738","issn":["1007-8738"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u7ec6\u80de\u4e0e\u5206\u5b50\u514d\u75ab\u5b66\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W212454257","https://openalex.org/W1595683733","https://openalex.org/W1599313041","https://openalex.org/W2358664106","https://openalex.org/W916911935","https://openalex.org/W1180333148","https://openalex.org/W1991912865","https://openalex.org/W2341329893","https://openalex.org/W1133639101","https://openalex.org/W859336747"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"study":[2],"the":[3,61,130,167],"effects":[4],"of":[5,12,135,143,148,154,162],"BMP-2":[6,71,136,155,176,179],"and":[7,32,37,44,72,85,97,115,129,152,180],"FGF-2":[8,75,170,181],"on":[9],"osteoblast":[10,131,189],"differentiation":[11,108,132],"murine":[13,184],"MSCs":[14,62,185],"in":[15],"vitro.":[16],"METHODS:":[17],"The":[18,146],"bone":[19,40],"marrow":[20,41],"cells":[21,58],"were":[22,34,53,63,76,102,117,138],"collected":[23],"from":[24],"3-18":[25],"month":[26],"old":[27],"C57BL/6J":[28],"mice":[29],"(50":[30],"mice),":[31],"they":[33,52],"isolated,":[35],"enriched":[36],"expanded":[38],"using":[39],"adherent":[42],"culture,":[43],"then":[45],"purified":[46],"by":[47,105,119],"immunomagnetic":[48],"microbeads.":[49],"At":[50],"last":[51],"identified":[54],"as":[55],"mesenchymal":[56],"stem":[57],"(MSCs).":[59],"After":[60],"cultured":[64],"adherently":[65],"for":[66,82],"24":[67],"hours,":[68],"100":[69],"microg/L":[70],"0.5":[73],"nmol/L":[74],"added":[77],"into":[78,188],"osteogenic":[79,144,163],"media":[80],"separately":[81],"7,":[83],"14":[84],"21":[86],"days,":[87],"alkaline":[88,92],"phosphatase":[89,93],"(ALP)":[90],"staining,":[91,96],"activities,":[94,126],"Vonkossa":[95],"Alizarin":[98],"red":[99],"S":[100],"staining":[101],"performed":[103],"step":[104],"step.":[106],"Osteoblast":[107],"marker":[109,133],"genes":[110,134],"including":[111],"Runx2/cbfa1,":[112,149],"ALP,":[113,150],"collagen-1,":[114,151],"osteocalcin":[116,153],"investigated":[118],"RT":[120],"real":[121],"time":[122],"PCR.":[123],"RESULTS:":[124],"ALP":[125],"calcium":[127],"deposition":[128],"group":[137,156],"markedly":[139],"higher":[140],"than":[141,160,175],"those":[142],"group.":[145,164,177],"mRNA":[147],"was":[157,166],"highly":[158],"expressed":[159],"that":[161],"It":[165],"same":[168],"with":[169],"group,":[171],"but":[172],"less":[173],"evident":[174],"CONCLUSION:":[178],"can":[182],"induce":[183],"to":[186],"differentiate":[187],"at":[190],"different":[191],"degrees.":[192]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
