{"id":"https://openalex.org/W977050207","doi":"https://doi.org/10.1371/journal.pone.0133274","title":"Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes","display_name":"Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes","publication_year":2015,"publication_date":"2015-07-21","ids":{"openalex":"https://openalex.org/W977050207","doi":"https://doi.org/10.1371/journal.pone.0133274","mag":"977050207","pmid":"https://pubmed.ncbi.nlm.nih.gov/26196737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510596"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0133274","doi":"https://doi.org/10.1371/journal.pone.0133274","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133274","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133274&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133274&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jie Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jie Liu","raw_affiliation_strings":["The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada","Division of Cardiology, University Health Network, Toronto, Ontario, Canada","The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Cardiology, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019568261","display_name":"Kyoung-Han Kim","orcid":"https://orcid.org/0000-0002-0433-656X","observed_orcids":["https://orcid.org/0000-0002-0433-656X"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kyoung-Han Kim","raw_affiliation_strings":["The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada","Division of Cardiology, University Health Network, Toronto, Ontario, Canada","Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada","The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Division of Cardiology, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058017240","display_name":"Michael J. Morales","orcid":"https://orcid.org/0000-0002-6528-4927","observed_orcids":["https://orcid.org/0000-0002-6528-4927","https://orcid.org/0000-0002-1732-2765"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Morales","raw_affiliation_strings":["Department of Physiology & Biophysics, University at Buffalo, the State University of New York, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Biophysics, University at Buffalo, the State University of New York, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083597794","display_name":"Scott Patrick Heximer","orcid":"https://orcid.org/0000-0001-5489-9240","observed_orcids":["https://orcid.org/0000-0001-5489-9240"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Scott P. Heximer","raw_affiliation_strings":["The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007919331","display_name":"Chi\u2010chung Hui","orcid":"https://orcid.org/0000-0001-7047-6694","observed_orcids":["https://orcid.org/0000-0001-7047-6694"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Chi-chung Hui","raw_affiliation_strings":["Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada; The Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada","The Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada; The Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"The Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085059825","display_name":"Peter H. Backx","orcid":"https://orcid.org/0000-0003-0497-776X","observed_orcids":["https://orcid.org/0000-0003-0497-776X"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Peter H. Backx","raw_affiliation_strings":["The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada","Division of Cardiology, University Health Network, Toronto, Ontario, Canada","The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Cardiology, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007919331","https://openalex.org/A5085059825"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2801317318"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.8156,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8573893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"7","first_page":"e0133274","last_page":"e0133274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kv4-3","display_name":"Kv4.3","score":0.9020000100135803},{"id":"https://openalex.org/keywords/kv4-2","display_name":"Kv4.2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/kchip2","display_name":"KChIP2","score":0.8560000061988831},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ventricular-repolarization-heterogeneity","display_name":"ventricular repolarization heterogeneity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C101404756","wikidata":"https://www.wikidata.org/wiki/Q5038336","display_name":"Cardiac transient outward potassium current","level":4,"score":0.8370324373245239},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.810728132724762},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.6643710732460022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49104762077331543},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4812700152397156},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.467519074678421},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4526512324810028},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4424588680267334},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4360715448856354},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.41253432631492615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38994553685188293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3530077338218689},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3265199065208435},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.31026116013526917},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.3053727447986603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23759371042251587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22184336185455322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10724186897277832},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08349955081939697}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013111","descriptor_name":"Spider Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051605","descriptor_name":"Kv Channel-Interacting Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051605","descriptor_name":"Kv Channel-Interacting Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051605","descriptor_name":"Kv Channel-Interacting Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051672","descriptor_name":"Shal Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051672","descriptor_name":"Shal Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051672","descriptor_name":"Shal Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0133274","doi":"https://doi.org/10.1371/journal.pone.0133274","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133274","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133274&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3489342","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510596","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4510596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26196737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26196737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.4613","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.4613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/90/6b/pone.0133274.PMC4510596.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:19289de16fdb4740aff0c7bac1abffcc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/19289de16fdb4740aff0c7bac1abffcc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 7, p e0133274 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0133274","doi":"https://doi.org/10.1371/journal.pone.0133274","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133274","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133274&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1371184209","display_name":null,"funder_award_id":"MOP119339","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W977050207.pdf","grobid_xml":"https://content.openalex.org/works/W977050207.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W117518344","https://openalex.org/W641965581","https://openalex.org/W1558473063","https://openalex.org/W1591593323","https://openalex.org/W1963711658","https://openalex.org/W1970186680","https://openalex.org/W1977407477","https://openalex.org/W1982359426","https://openalex.org/W1983155198","https://openalex.org/W1984149524","https://openalex.org/W1990172814","https://openalex.org/W1994693311","https://openalex.org/W1995005951","https://openalex.org/W2004430907","https://openalex.org/W2005529529","https://openalex.org/W2006481264","https://openalex.org/W2025249827","https://openalex.org/W2030059555","https://openalex.org/W2038375865","https://openalex.org/W2047314686","https://openalex.org/W2055033654","https://openalex.org/W2075213530","https://openalex.org/W2082385042","https://openalex.org/W2100486472","https://openalex.org/W2106796171","https://openalex.org/W2107351696","https://openalex.org/W2113625902","https://openalex.org/W2116169862","https://openalex.org/W2116533376","https://openalex.org/W2116768897","https://openalex.org/W2121905278","https://openalex.org/W2130137227","https://openalex.org/W2132318327","https://openalex.org/W2134367999","https://openalex.org/W2143470172","https://openalex.org/W2147580778","https://openalex.org/W2151303234","https://openalex.org/W2151770583","https://openalex.org/W2153748973","https://openalex.org/W2160931587","https://openalex.org/W2169029824","https://openalex.org/W2169669126","https://openalex.org/W2326565381","https://openalex.org/W2328093688","https://openalex.org/W2412874155","https://openalex.org/W2467956690","https://openalex.org/W4293099972"],"related_works":["https://openalex.org/W7100253290","https://openalex.org/W2022138433","https://openalex.org/W844681022","https://openalex.org/W2055033654","https://openalex.org/W2000769130","https://openalex.org/W2134367999","https://openalex.org/W2005529529","https://openalex.org/W2144762767","https://openalex.org/W2230834630","https://openalex.org/W2154527766"],"abstract_inverted_index":{"Gradients":[0],"of":[1,12,18,109,119,129,188],"the":[2,38,43,84,101,107,120,138,186],"fast":[3],"transient":[4],"outward":[5],"K+":[6,98],"current":[7],"(Ito,f)":[8],"contribute":[9],"to":[10,34,76,95,150],"heterogeneity":[11],"ventricular":[13,81,140],"repolarization":[14],"in":[15,60,68,79,100,131,146,155,162,167,174,185,210],"a":[16,114,172,192,200],"number":[17],"species.":[19],"Cardiac":[20],"Ito,f":[21,32,50,62,73,116,135,153,183,207],"levels":[22],"and":[23,53,70],"gradients":[24,136,161],"change":[25],"notably":[26],"with":[27,65,160,191],"heart":[28],"disease.":[29],"Human":[30],"cardiac":[31,49,61],"appears":[33],"be":[35,77,199],"encoded":[36],"by":[37,144],"Kv4.3":[39,54,130],"pore-forming":[40],"\u03b1-subunit":[41],"plus":[42,56],"auxiliary":[44],"KChIP2":[45,163],"\u03b2-subunit":[46],"while":[47,166],"mouse":[48,80],"requires":[51],"Kv4.2":[52,69,85,175],"\u03b1-subunits":[55],"KChIP2.":[57,71],"Regional":[58],"differences":[59,67],"are":[63],"associated":[64,159],"expression":[66,128,165],"Although":[72],"was":[74,158,170],"reported":[75],"absent":[78],"cardiomyocytes":[82],"lacking":[83],"gene":[86],"(Kv4.2-/-)":[87],"when":[88],"short":[89],"depolarizing":[90],"voltage":[91],"pulses":[92],"were":[93,142],"used":[94],"activate":[96],"voltage-gated":[97],"currents,":[99],"present":[102],"study,":[103],"we":[104,179],"showed":[105],"that":[106,181],"use":[108],"long":[110],"depolarization":[111],"steps":[112],"revealed":[113],"heteropodatoxin-sensitive":[115],"(at":[117],"~40%":[118],"wild-type":[121,168],"levels).":[122],"Immunohistological":[123],"studies":[124],"further":[125],"demonstrated":[126],"membrane":[127],"Kv4.2-/-":[132,147,156,196],"cardiomyocytes.":[133],"Transmural":[134],"across":[137],"left":[139],"wall":[141],"reduced":[143,193],"~3.5-fold":[145],"heart,":[148],"compared":[149],"wild-type.":[151],"The":[152],"gradient":[154,173],"hearts":[157],"mRNA":[164],"there":[169],"also":[171],"expression.":[176],"In":[177],"conclusion,":[178],"found":[180],"Kv4.3-based":[182,206],"exists":[184],"absence":[187],"Kv4.2,":[189],"although":[190],"transmural":[194],"gradient.":[195],"mice":[197],"may":[198],"useful":[201],"animal":[202],"model":[203],"for":[204],"studying":[205],"as":[208],"observed":[209],"humans.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}