{"id":"https://openalex.org/W9764376","doi":null,"title":"Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.","display_name":"Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W9764376","mag":"9764376","pmid":"https://pubmed.ncbi.nlm.nih.gov/1574185"},"language":"en","primary_location":{"id":"pmid:1574185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1574185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023585572","display_name":"Dick Lindhout","orcid":"https://orcid.org/0000-0001-9580-624X","observed_orcids":["https://orcid.org/0000-0001-9580-624X"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D Lindhout","raw_affiliation_strings":["Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041672590","display_name":"H. Meinardi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Meinardi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111580415","display_name":"Jaap W. A. Meijer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W Meijer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109943894","display_name":"Heinz Nau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Nau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5859,"has_fulltext":false,"cited_by_count":159,"citation_normalized_percentile":{"value":0.94086728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"4 Suppl 5","first_page":"94","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9940000176429749},{"id":"https://openalex.org/keywords/teratogenesis","display_name":"teratogenesis","score":0.906000018119812},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.4399999976158142},{"id":"https://openalex.org/keywords/prescribing-policy","display_name":"prescribing policy","score":0.640999972820282},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.8209999799728394},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9259999990463257},{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primidone","display_name":"primidone","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6269999742507935},{"id":"https://openalex.org/keywords/spinal-defects","display_name":"spinal defects","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hypospadias","display_name":"hypospadias","score":0.9380000233650208},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.8349999785423279},{"id":"https://openalex.org/keywords/facial-clefts","display_name":"facial clefts","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dysmorphia","display_name":"dysmorphia","score":0.7289999723434448},{"id":"https://openalex.org/keywords/developmental-delay","display_name":"developmental delay","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2777992146","wikidata":"https://www.wikidata.org/wiki/Q420383","display_name":"Primidone","level":4,"score":0.9655153751373291},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.8552486896514893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8164605498313904},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.7591711282730103},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.706169843673706},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6561097502708435},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6543623208999634},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5382112860679626},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5261076092720032},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.5150935053825378},{"id":"https://openalex.org/C2777990738","wikidata":"https://www.wikidata.org/wiki/Q1132108","display_name":"Hypospadias","level":2,"score":0.5118326544761658},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.47666695713996887},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.4463028907775879},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3112904727458954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3072274923324585},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1875823736190796},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.1846875250339508},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17652016878128052},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08134016394615173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1574185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1574185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"mag:9764376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1574185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2969209050","https://openalex.org/W198124148","https://openalex.org/W2470407196","https://openalex.org/W4375926802","https://openalex.org/W1990622933","https://openalex.org/W1981740099","https://openalex.org/W2147848178","https://openalex.org/W4251199230","https://openalex.org/W31166242","https://openalex.org/W2289215193"],"abstract_inverted_index":{"We":[0],"analyzed":[1],"the":[2,7,93,147,156,166],"influence":[3],"of":[4,9,19,44,58,66,95,113,151,158,168],"changes":[5],"in":[6,21,71,134,160,174],"prescribing":[8,94,161],"antiepileptic":[10],"drugs":[11,172],"to":[12,30,35,154,164],"pregnant":[13],"women":[14],"on":[15],"frequency":[16],"and":[17,64,107,129,163],"pattern":[18],"malformations":[20],"their":[22],"offspring":[23],"by":[24],"comparing":[25],"two":[26],"consecutive":[27],"cohorts":[28],"(1972":[29],"1979,":[31],"cohort":[32,37,40,91],"A;":[33],"1980":[34],"1985,":[36],"B).":[38],"In":[39,90],"A,":[41],"15":[42],"(10%)":[43],"151":[45],"exposed,":[46,115],"live-born":[47,116],"infants":[48,117],"had":[49,100,109,118],"one":[50],"or":[51,81,84,98,142],"more":[52],"congenital":[53,59,119],"anomalies,":[54],"which":[55],"consisted":[56],"primarily":[57],"heart":[60],"defects,":[61],"facial":[62],"clefts,":[63],"syndromes":[65],"dysmorphia":[67],"with":[68,73,80,105,136,139],"developmental":[69],"retardation,":[70],"association":[72,135],"polytherapy":[74],"(carbamazepine":[75],"plus":[76,78,86,88],"phenobarbitone":[77,85],"valproate,":[79,140],"without":[82],"phenytoin,":[83,97],"phenytoin":[87],"primidone).":[89],"B,":[92],"phenobarbitone,":[96],"primidone":[99],"dropped":[101],"markedly,":[102],"whereas":[103],"monotherapy":[104],"valproate":[106],"carbamazepine":[108],"increased.":[110],"Thirteen":[111],"(7.6%)":[112],"172":[114],"anomalies.":[120],"The":[121,144],"most":[122],"frequent":[123],"anomalies":[124],"were":[125],"spinal":[126],"defects":[127],"(four)":[128],"glandular":[130],"hypospadias":[131],"(three),":[132],"all":[133],"maternal":[137],"therapy":[138],"carbamazepine,":[141],"both.":[143],"results":[145],"underline":[146],"need":[148],"for":[149],"continuation":[150],"prospective":[152],"studies":[153],"monitor":[155],"effect":[157],"change":[159],"policies":[162],"evaluate":[165],"role":[167],"metabolic":[169],"interactions":[170],"between":[171],"prescribed":[173],"combination.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
