{"id":"https://openalex.org/W976252500","doi":"https://doi.org/10.1016/j.bmcl.2015.06.070","title":"Synthesis and cytotoxic properties of tryptamine derivatives","display_name":"Synthesis and cytotoxic properties of tryptamine derivatives","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W976252500","doi":"https://doi.org/10.1016/j.bmcl.2015.06.070","mag":"976252500","pmid":"https://pubmed.ncbi.nlm.nih.gov/26174553"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2015.06.070","doi":"https://doi.org/10.1016/j.bmcl.2015.06.070","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2015.06.070","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090308448","display_name":"Rinat Faritovich Salikov","orcid":"https://orcid.org/0000-0002-7901-600X","observed_orcids":["https://orcid.org/0000-0002-7901-600X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210088206","display_name":"N.D. Zelinsky Institute of Organic Chemistry","ror":"https://ror.org/007phxq15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210088206","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Rinat F. Salikov","raw_affiliation_strings":["N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113838174","display_name":"Alexander Yu. Belyy","orcid":"https://orcid.org/0000-0002-4948-6238","observed_orcids":["https://orcid.org/0000-0002-4948-6238"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210088206","display_name":"N.D. Zelinsky Institute of Organic Chemistry","ror":"https://ror.org/007phxq15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210088206","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aleksandr Yu. Belyy","raw_affiliation_strings":["N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation; Higher Chemical College, Russian Academy of Sciences, Moscow, Russian Federation","Higher Chemical College, Russian Academy of Sciences, Moscow, Russian Federation","N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation; Higher Chemical College, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088206"]},{"raw_affiliation_string":"Higher Chemical College, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035"]},{"raw_affiliation_string":"N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074559789","display_name":"Nailya S. Khusnutdinova","orcid":"https://orcid.org/0000-0003-0460-8382","observed_orcids":["https://orcid.org/0000-0003-0460-8382"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210112273","display_name":"Institute of Biochemistry and Genetics of Ufa Scientific Centre","ror":"https://ror.org/02a9vnt59","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210112273","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nailya S. Khusnutdinova","raw_affiliation_strings":["Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, Ufa, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, Ufa, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210112273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028038450","display_name":"Yulia V. Vakhitova","orcid":"https://orcid.org/0000-0002-7062-8261","observed_orcids":["https://orcid.org/0000-0002-7062-8261","https://orcid.org/0000-0002-4800-9886"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210112273","display_name":"Institute of Biochemistry and Genetics of Ufa Scientific Centre","ror":"https://ror.org/02a9vnt59","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210112273","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yulia V. Vakhitova","raw_affiliation_strings":["Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, Ufa, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, Ufa, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210112273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057337671","display_name":"Yury Vasil'evich Tomilov","orcid":"https://orcid.org/0000-0002-3433-7571","observed_orcids":["https://orcid.org/0000-0002-3433-7571"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210088206","display_name":"N.D. Zelinsky Institute of Organic Chemistry","ror":"https://ror.org/007phxq15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210088206","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Yury V. Tomilov","raw_affiliation_strings":["N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation. Electronic address: tom@ioc.ac.ru","N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation. Electronic address: tom@ioc.ac.ru","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088206"]},{"raw_affiliation_string":"N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088206"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057337671"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088206"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.96,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.69321757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"17","first_page":"3597","last_page":"3600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4796999990940094,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4796999990940094,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.17910000681877136,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms","score":0.059700001031160355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptamine-derivatives","display_name":"tryptamine derivatives","score":0.984000027179718},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mitochondrial-damage","display_name":"mitochondrial damage","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cell-type-specificity","display_name":"cell type specificity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/benzyl-substitution","display_name":"benzyl substitution","score":0.46399998664855957},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.899476170539856},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.8843832015991211},{"id":"https://openalex.org/C2777135210","wikidata":"https://www.wikidata.org/wiki/Q409439","display_name":"Tryptamine","level":2,"score":0.7777907848358154},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7303997278213501},{"id":"https://openalex.org/C2909645108","wikidata":"https://www.wikidata.org/wiki/Q10705510","display_name":"Tryptamines","level":3,"score":0.7301380634307861},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7208058834075928},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5715814232826233},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5505606532096863},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5401278138160706},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5375497341156006},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5319896936416626},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5175813436508179},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.5168550610542297},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.49498480558395386},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4078952670097351},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3242899477481842},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.24396806955337524},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.20491385459899902},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07368883490562439},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07364001870155334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06640532612800598},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.05951350927352905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014363","descriptor_name":"Tryptamines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014363","descriptor_name":"Tryptamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014363","descriptor_name":"Tryptamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2015.06.070","doi":"https://doi.org/10.1016/j.bmcl.2015.06.070","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2015.06.070","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:26174553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26174553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1964369071","https://openalex.org/W1970516806","https://openalex.org/W1978793481","https://openalex.org/W1996740714","https://openalex.org/W2002020493","https://openalex.org/W2041898141","https://openalex.org/W2058759202","https://openalex.org/W2063110432","https://openalex.org/W2146926552","https://openalex.org/W2155201769","https://openalex.org/W2160923905","https://openalex.org/W2320636896","https://openalex.org/W2333815239","https://openalex.org/W2949251231","https://openalex.org/W2952383150","https://openalex.org/W2952555475","https://openalex.org/W2953266189"],"related_works":["https://openalex.org/W2774714762","https://openalex.org/W3122148679","https://openalex.org/W4389148118","https://openalex.org/W2916493238","https://openalex.org/W2006503263","https://openalex.org/W3138854534","https://openalex.org/W3203149712","https://openalex.org/W4377823274","https://openalex.org/W2346166970","https://openalex.org/W3199669915"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}