{"id":"https://openalex.org/W975540697","doi":"https://doi.org/10.1007/978-1-59259-777-2_13","title":"Nucleic Acids As Gene-Targeting Therapeutics","display_name":"Nucleic Acids As Gene-Targeting Therapeutics","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W975540697","doi":"https://doi.org/10.1007/978-1-59259-777-2_13","mag":"975540697"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-777-2_13","doi":"https://doi.org/10.1007/978-1-59259-777-2_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-777-2_13","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acid Therapeutics in Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W562243885","display_name":"Nucleic Acid Therapeutics in Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023624767","display_name":"Joanna Opalinska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna B. Opalinska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003434228","display_name":"Susan E. Shetzline","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan E. Shetzline","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07585233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"167","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid-therapeutics","display_name":"nucleic acid therapeutics","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.8040000200271606},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gene-expression-modulation","display_name":"gene expression modulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/molecular-medicine","display_name":"molecular medicine","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6119405627250671},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5759075880050659},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5310488343238831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5015869140625},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4332507252693176},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4250187575817108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4120846390724182},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3962509036064148},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3496166467666626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12341246008872986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-777-2_13","doi":"https://doi.org/10.1007/978-1-59259-777-2_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-777-2_13","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acid Therapeutics in Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7300000190734863}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1508773001","https://openalex.org/W1590127176","https://openalex.org/W1598719623","https://openalex.org/W1736564208","https://openalex.org/W1824700770","https://openalex.org/W1911252495","https://openalex.org/W1919853884","https://openalex.org/W1960130068","https://openalex.org/W1978812213","https://openalex.org/W1981747163","https://openalex.org/W1984718218","https://openalex.org/W1985791255","https://openalex.org/W1988711597","https://openalex.org/W1990579613","https://openalex.org/W1991900257","https://openalex.org/W1994666467","https://openalex.org/W1998919839","https://openalex.org/W1999070120","https://openalex.org/W1999239957","https://openalex.org/W2000025384","https://openalex.org/W2000759543","https://openalex.org/W2005333148","https://openalex.org/W2011893695","https://openalex.org/W2014764441","https://openalex.org/W2015290966","https://openalex.org/W2017761250","https://openalex.org/W2026973552","https://openalex.org/W2030889696","https://openalex.org/W2032264324","https://openalex.org/W2036242475","https://openalex.org/W2047366876","https://openalex.org/W2051434104","https://openalex.org/W2056745327","https://openalex.org/W2059884965","https://openalex.org/W2067716515","https://openalex.org/W2073115409","https://openalex.org/W2073564321","https://openalex.org/W2074156639","https://openalex.org/W2079266971","https://openalex.org/W2091128862","https://openalex.org/W2098082753","https://openalex.org/W2099515475","https://openalex.org/W2106080188","https://openalex.org/W2108723848","https://openalex.org/W2111936872","https://openalex.org/W2113211717","https://openalex.org/W2113591882","https://openalex.org/W2116887336","https://openalex.org/W2129683520","https://openalex.org/W2134714439","https://openalex.org/W2144473160","https://openalex.org/W2146135060","https://openalex.org/W2147682442","https://openalex.org/W2167742104","https://openalex.org/W2185245914","https://openalex.org/W2207680991","https://openalex.org/W2271931687","https://openalex.org/W2290539832","https://openalex.org/W2313594316","https://openalex.org/W2313609969","https://openalex.org/W2402274983","https://openalex.org/W2404816726","https://openalex.org/W2415040171","https://openalex.org/W2417361501","https://openalex.org/W2418478757"],"related_works":["https://openalex.org/W2118019616","https://openalex.org/W562243885","https://openalex.org/W2153519969","https://openalex.org/W4399308726","https://openalex.org/W2044580645","https://openalex.org/W2157150767","https://openalex.org/W2284153766","https://openalex.org/W18129917","https://openalex.org/W2327261824","https://openalex.org/W4250835019"],"abstract_inverted_index":{"For":[0],"diseases":[1,102],"that":[2,27],"are":[3,46],"intrinsic":[4],"to":[5,18,62],"the":[6,24,32,49,52,76,85,98,107,119],"human":[7],"body,":[8],"there":[9],"is":[10,60],"ultimately":[11],"a":[12,64,68],"molecular":[13,122],"pathogenesis,":[14],"either":[15],"known":[16],"or":[17,35,75],"be":[19,82],"discovered.":[20],"This":[21],"being":[22],"so,":[23],"possibility":[25],"exists":[26],"manipulation":[28],"of":[29,31,51,70,78,87,100],"expression":[30],"causative":[33],"gene,":[34],"genes,":[36],"could":[37],"have":[38],"significant":[39],"therapeutic":[40],"consequences.":[41],"Furthermore,":[42],"because":[43],"biological":[44],"processes":[45],"virtually":[47],"always":[48],"result":[50],"balance":[53],"between":[54],"stimulatory":[55],"and":[56,96,112],"inhibitory":[57],"effects,":[58],"it":[59],"difficult":[61],"imagine":[63],"situation":[65],"where":[66],"silencing":[67],"set":[69],"genes":[71],"involved":[72],"in":[73,97,103,121],"one":[74],"other":[77],"these":[79],"effects":[80],"couldn\u2019t":[81],"exploited":[83],"for":[84],"purposes":[86],"treating":[88],"disease.":[89],"Such":[90],"therapies":[91],"might":[92,105],"enjoy":[93],"exquisite":[94],"specificity,":[95],"case":[99],"malignant":[101],"particular,":[104],"spare":[106],"patient":[108],"from":[109],"many":[110],"morbid,":[111],"occasionally":[113],"fatal,":[114],"iatrogenic":[115],"side":[116],"effects.":[117],"Hence":[118],"interest":[120],"medicines.":[123]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
