{"id":"https://openalex.org/W97531722","doi":null,"title":"Clinical perspectives on atypical antipsychotics for treatment of agitation.","display_name":"Clinical perspectives on atypical antipsychotics for treatment of agitation.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W97531722","mag":"97531722","pmid":"https://pubmed.ncbi.nlm.nih.gov/16965192"},"language":"en","primary_location":{"id":"pmid:16965192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16965192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111876732","display_name":"Eric D. Caine","orcid":"https://orcid.org/0000-0002-4859-9679","observed_orcids":["https://orcid.org/0000-0002-4859-9679"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric D Caine","raw_affiliation_strings":["Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA. eric_caine@urmc.rochester.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA. eric_caine@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111876732"],"corresponding_institution_ids":["https://openalex.org/I28792581"],"apc_list":null,"apc_paid":null,"fwci":1.0957,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75749008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"67 Suppl 10","issue":null,"first_page":"22","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13944","display_name":"Psychiatric care and mental health services","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":1.0},{"id":"https://openalex.org/keywords/agitation","display_name":"agitation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9700000286102295},{"id":"https://openalex.org/keywords/manic-symptoms","display_name":"manic symptoms","score":0.9399999976158142},{"id":"https://openalex.org/keywords/long-term-care","display_name":"long-term care","score":0.722000002861023},{"id":"https://openalex.org/keywords/behavioral-emergencies","display_name":"behavioral emergencies","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.5170000195503235},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2776153860","wikidata":"https://www.wikidata.org/wiki/Q394129","display_name":"Psychomotor agitation","level":2,"score":0.7117277979850769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6719872951507568},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6140539050102234},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6000787019729614},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.5492956638336182},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5148628950119019},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.49508944153785706},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.48431769013404846},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.472202867269516},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3068509101867676},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.2751207947731018},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.1464952826499939},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10775956511497498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09629735350608826},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004632","descriptor_name":"Emergency Medical Services","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011595","descriptor_name":"Psychomotor Agitation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011595","descriptor_name":"Psychomotor Agitation","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012565","descriptor_name":"Schizophrenic Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16965192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16965192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},{"id":"mag:97531722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16965192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1541180996","https://openalex.org/W2751509074","https://openalex.org/W2164600325","https://openalex.org/W2101184898","https://openalex.org/W2006594575","https://openalex.org/W1983511323","https://openalex.org/W7100341566","https://openalex.org/W2162361841","https://openalex.org/W1999041392","https://openalex.org/W2103172029"],"abstract_inverted_index":{"In":[0],"the":[1,3,24,67,73],"past,":[2],"use":[4,157],"of":[5,17,26,41,147],"atypical":[6,42,60,88,118],"antipsychotics":[7,43,61,89,119],"in":[8,19,44,47,72,80,93,124,158],"treating":[9],"acute":[10,74,122,141],"agitation":[11,123],"was":[12],"limited":[13],"by":[14,23,111],"a":[15],"lack":[16,25],"data":[18,38],"behavioral":[20],"emergencies":[21],"and":[22,50,64,102,116,127],"intramuscular":[27,59,70],"formulations":[28],"or":[29,82],"alternate":[30],"rapid-acting":[31],"oral":[32,78,117],"formulations.":[33],"This":[34],"article":[35],"evaluates":[36],"current":[37],"from":[39,69],"studies":[40],"agitated":[45,159],"patients":[46,55,95,161],"both":[48,125],"short-":[49],"long-term":[51,128],"care":[52,75,129],"settings.":[53,84,130],"For":[54,131],"with":[56,162],"underlying":[57],"psychosis,":[58],"are":[62,136],"effective":[63],"help":[65],"ease":[66],"transition":[68],"therapy":[71],"setting":[76],"to":[77],"dosing":[79],"inpatient":[81],"community":[83],"Evidence":[85],"exists":[86],"that":[87,103],"demonstrate":[90],"antiagitation":[91,113],"effects":[92],"schizophrenic":[94],"for":[96,140],"as":[97,99,142,144],"long":[98],"10":[100],"weeks":[101],"overall":[104],"clinical":[105],"response":[106],"may":[107],"be":[108],"partly":[109],"mediated":[110],"these":[112,134],"properties.":[114],"Intramuscular":[115],"effectively":[120],"treat":[121],"emergency":[126],"bipolar":[132],"patients,":[133],"agents":[135],"valid":[137],"therapeutic":[138],"options":[139],"well":[143],"longer-term":[145],"alleviation":[146],"manic":[148],"symptoms,":[149],"including":[150],"agitation.":[151],"Safety":[152],"concerns,":[153],"however,":[154],"limit":[155],"their":[156],"elderly":[160],"dementia.":[163]},"counts_by_year":[{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}