{"id":"https://openalex.org/W97490157","doi":null,"title":"Precocious pubarche in girls and the development of androgen excess.","display_name":"Precocious pubarche in girls and the development of androgen excess.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W97490157","mag":"97490157","pmid":"https://pubmed.ncbi.nlm.nih.gov/11117666"},"language":"en","primary_location":{"id":"pmid:11117666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11117666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric endocrinology & metabolism : JPEM","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089989142","display_name":"Lourdes Ib\u00e1\u00f1ez","orcid":"https://orcid.org/0000-0003-4595-7191","observed_orcids":["https://orcid.org/0000-0003-4595-7191","https://orcid.org/0000-0002-5058-1603"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L Ib\u00e1\u00f1ez","raw_affiliation_strings":["Hospital Sant Joan de D\u00e9u, University of Barcelona, Spain. libanez@hsjdbcn.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Sant Joan de D\u00e9u, University of Barcelona, Spain. libanez@hsjdbcn.org","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048780093","display_name":"Neus Potau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Potau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016379322","display_name":"David B. Dunger","orcid":"https://orcid.org/0000-0002-2566-9304","observed_orcids":["https://orcid.org/0000-0002-2566-9304","https://orcid.org/0000-0002-3176-3495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Dunger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063054543","display_name":"Francis de Zegher","orcid":"https://orcid.org/0000-0002-2491-5884","observed_orcids":["https://orcid.org/0000-0002-2491-5884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F de Zegher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1492,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.73192313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13 Suppl 5","issue":null,"first_page":"1261","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/premature-pubarche","display_name":"premature pubarche","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ovarian-hyperandrogenism","display_name":"ovarian hyperandrogenism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hyperinsulinism","display_name":"hyperinsulinism","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anovulation","display_name":"anovulation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gnrh-agonist-stimulation","display_name":"GnRH agonist stimulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/17-hydroxyprogesterone","display_name":"17-hydroxyprogesterone","score":0.9079999923706055},{"id":"https://openalex.org/keywords/adolescent-girls","display_name":"adolescent girls","score":0.5429999828338623},{"id":"https://openalex.org/keywords/pubertal-development","display_name":"pubertal development","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2910605048","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Androgen Excess","level":5,"score":0.9194982051849365},{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.8763007521629333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7441763877868652},{"id":"https://openalex.org/C2780853582","wikidata":"https://www.wikidata.org/wiki/Q25556","display_name":"Anovulation","level":5,"score":0.7408064603805542},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7399894595146179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6781712770462036},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.6129845380783081},{"id":"https://openalex.org/C2777368190","wikidata":"https://www.wikidata.org/wiki/Q477390","display_name":"Hyperinsulinism","level":4,"score":0.6001309156417847},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5248344540596008},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.5180637836456299},{"id":"https://openalex.org/C2776371013","wikidata":"https://www.wikidata.org/wiki/Q1620594","display_name":"hirsutism","level":5,"score":0.49009832739830017},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.46928346157073975},{"id":"https://openalex.org/C2778367240","wikidata":"https://www.wikidata.org/wiki/Q224513","display_name":"Precocious puberty","level":3,"score":0.44862136244773865},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.30996716022491455},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.19823268055915833},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1945156753063202},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1897042691707611},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1522817313671112}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017588","descriptor_name":"Hyperandrogenism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11117666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11117666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric endocrinology & metabolism : JPEM","raw_type":"Journal Article"},{"id":"mag:97490157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11117666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2071231859","https://openalex.org/W1977556591","https://openalex.org/W2072284140","https://openalex.org/W2093725365","https://openalex.org/W2074747231","https://openalex.org/W6986662487","https://openalex.org/W2001327640","https://openalex.org/W2009295157","https://openalex.org/W4233483317","https://openalex.org/W2166391916"],"abstract_inverted_index":{"The":[0,32,54],"prevalence":[1,89],"of":[2,16,23,29,40,73,90,100,103,119,157,174],"ovarian":[3,33,47],"hyperandrogenism,":[4],"hyperinsulinism":[5,55],"and":[6,43,56,61,65,80,85,115],"dyslipidemia":[7,57],"is":[8,35],"increased":[9,88,168],"among":[10],"adolescent":[11],"girls":[12,146],"with":[13],"a":[14,135,154,162,171],"history":[15],"premature":[17,108,143],"pubarche":[18,144],"(defined":[19],"as":[20,153,161],"the":[21,27,98],"appearance":[22],"pubic":[24],"hair":[25],"before":[26,60],"age":[28],"8":[30],"yr).":[31],"hyperandrogenism":[34],"characterized":[36],"by":[37,44,69,86],"clinical":[38,101],"signs":[39,102],"androgen":[41,104],"excess":[42],"an":[45,87,167],"exaggerated":[46],"17-hydroxyprogesterone":[48],"response":[49],"to":[50,123,166],"GnRH":[51],"agonist":[52],"stimulation.":[53],"are":[58,66],"detectable":[59],"during":[62],"pubertal":[63],"development,":[64,158],"commonly":[67],"accompanied":[68],"low":[70,111],"serum":[71],"levels":[72],"insulin-like":[74],"growth":[75],"factor":[76],"binding-protein":[77],"1":[78],"(IGFBP-1)":[79],"sex":[81],"hormone-binding":[82],"globulin":[83],"(SHBG),":[84],"anovulation":[91,114],"from":[92],"late":[93],"adolescence":[94],"onwards,":[95],"even":[96],"in":[97,145],"absence":[99],"excess.":[105],"In":[106],"girls,":[107],"pubarche,":[109],"hyperinsulinism,":[110],"IGFBP-1,":[112],"dyslipidemia,":[113],"hyperandrogenism--and":[116],"some":[117],"combinations":[118],"these--have":[120],"been":[121],"related":[122],"reduced":[124],"fetal":[125],"growth,":[126],"indicating":[127],"that":[128,142],"these":[129,139],"constellations":[130],"or":[131],"sequences":[132],"may":[133],"have":[134],"prenatal":[136,175],"origin.":[137,176],"Together,":[138],"findings":[140],"suggest":[141],"should":[147],"no":[148],"longer":[149],"be":[150],"merely":[151],"regarded":[152],"normal":[155],"variant":[156],"but":[159],"rather":[160],"childhood":[163],"marker":[164],"pointing":[165],"risk":[169],"for":[170],"polyendocrine-metabolic":[172],"disorder":[173]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}