{"id":"https://openalex.org/W97451159","doi":null,"title":"Arsenic trioxide: an ancient drug revived.","display_name":"Arsenic trioxide: an ancient drug revived.","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W97451159","mag":"97451159","pmid":"https://pubmed.ncbi.nlm.nih.gov/23044323"},"language":"en","primary_location":{"id":"pmid:23044323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23044323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100734327","display_name":"Jin Zhou","orcid":"https://orcid.org/0000-0003-4316-9845","observed_orcids":["https://orcid.org/0000-0003-4316-9845","https://orcid.org/0000-0003-0228-3940","https://orcid.org/0000-0003-4367-0605"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Zhou","raw_affiliation_strings":["Department of Hematology, the First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, China. zhoujin1111@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, the First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, China. zhoujin1111@126.com","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210156501"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100734327"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210156501"],"apc_list":null,"apc_paid":null,"fwci":1.4699,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.80101526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"125","issue":"19","first_page":"3556","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":1.0},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7059999704360962},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7919999957084656},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6729999780654907},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7459999918937683},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.974414587020874},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.9407036900520325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7680391669273376},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5823453664779663},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5566128492355347},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4847821593284607},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42183858156204224},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4149208664894104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34599965810775757},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28497302532196045},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.2151593565940857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06252723932266235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23044323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23044323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:97451159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23044323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019057620","https://openalex.org/W2037632266","https://openalex.org/W2409567036","https://openalex.org/W2184585007","https://openalex.org/W2592281590","https://openalex.org/W4253160941","https://openalex.org/W2111279921","https://openalex.org/W2075662431","https://openalex.org/W2117870498","https://openalex.org/W2062188579"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"summarize":[2],"the":[3,11,26,81,108,129],"clinical":[4,158],"applications":[5,159],"of":[6,13,83,93,115,131,147,163],"arsenic":[7,67],"trioxide":[8],"(ATO)":[9],"in":[10,32,39,80,128,135,142,150,160],"treatment":[12,82,101,137,152],"acute":[14,64,94],"promyelocytic":[15,65],"leukemia":[16],"(APL),":[17],"as":[18,20],"well":[19],"non-APL":[21],"malignancies":[22],"and":[23,28,46,52,70,112,122],"to":[24,58],"discuss":[25],"mechanisms":[27,133,148],"adverse":[29,124],"effects":[30],"involved":[31,134,149],"ATO":[33,79,105,136,151],"administration.":[34],"DATA":[35],"SOURCES:":[36],"The":[37,126],"data":[38],"this":[40],"article":[41],"were":[42,85],"collected":[43],"from":[44,56],"PubMed":[45],"CHKD":[47],"database":[48],"with":[49,60,97,102,117,119],"relevant":[50],"English":[51],"Chinese":[53],"articles":[54],"published":[55],"1957":[57],"2011,":[59],"key":[61],"words":[62],"including":[63,75],"leukemia,":[66,96],"trioxide,":[68],"treatment,":[69],"mechanism.":[71],"STUDY":[72],"SELECTION:":[73],"Articles":[74],"any":[76],"information":[77],"about":[78],"APL":[84,88],"selected.":[86],"RESULTS:":[87],"is":[89],"a":[90,161],"rare":[91],"subtype":[92],"myeloid":[95],"dismal":[98],"prognosis":[99],"under":[100],"traditional":[103],"chemotherapy.":[104],"impressively":[106],"increases":[107],"complete":[109],"remission":[110],"rate":[111],"prolongs":[113],"survival":[114],"patients":[116],"APL,":[118],"only":[120],"mild":[121],"transient":[123],"effects.":[125],"advances":[127],"understanding":[130,146],"multiple":[132],"will":[138],"benefit":[139],"more":[140],"cancers":[141],"future.":[143],"CONCLUSION:":[144],"Deeper":[145],"may":[153],"provide":[154],"rationales":[155],"for":[156],"future":[157],"number":[162],"human":[164],"malignancies.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}