{"id":"https://openalex.org/W974199181","doi":"https://doi.org/10.2478/cttr-2013-0912","title":"Mainstream Smoke Chemistry and in Vitro and In Vivo Toxicity of the Reference Cigarettes 3R4F and 2R4F","display_name":"Mainstream Smoke Chemistry and in Vitro and In Vivo Toxicity of the Reference Cigarettes 3R4F and 2R4F","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W974199181","doi":"https://doi.org/10.2478/cttr-2013-0912","mag":"974199181"},"language":"en","primary_location":{"id":"doi:10.2478/cttr-2013-0912","doi":"https://doi.org/10.2478/cttr-2013-0912","is_oa":true,"landing_page_url":"https://doi.org/10.2478/cttr-2013-0912","pdf_url":"https://www.sciendo.com/pdf/10.2478/cttr-2013-0912","source":{"id":"https://openalex.org/S4210208843","display_name":"Beitr\u00e4ge zur Tabakforschung international","issn_l":"0173-783X","issn":["0173-783X","1612-9237"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beitr\u00e4ge zur Tabakforschung International/Contributions to Tobacco Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciendo.com/pdf/10.2478/cttr-2013-0912","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020887537","display_name":"Ewald Roemer","orcid":"https://orcid.org/0000-0001-5789-6360","observed_orcids":["https://orcid.org/0000-0001-5789-6360"]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"E Roemer","raw_affiliation_strings":["Philip Morris International Operations, Philip Morris Products S.A., Rue des Usines 90, 2000 Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International Operations, Philip Morris Products S.A., Rue des Usines 90, 2000 Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044651392","display_name":"Heike Schramke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800621710","display_name":"Philip Morris International (Switzerland)","ror":"https://ror.org/03z9zz970","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800621710","https://openalex.org/I4210088192"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H Schramke","raw_affiliation_strings":["Philip Morris International Operations, Philip Morris Products S.A., Rue des Usines 90, 2000 Neuch\u00e2tel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International Operations, Philip Morris Products S.A., Rue des Usines 90, 2000 Neuch\u00e2tel, Switzerland","institution_ids":["https://openalex.org/I2800621710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014196341","display_name":"H. Weiler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Weiler","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112411481","display_name":"Ansgar Buettner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Buettner","raw_affiliation_strings":["Histovia GmbH, Schoene Aussicht 5, 51491 Overath, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histovia GmbH, Schoene Aussicht 5, 51491 Overath, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070308279","display_name":"Sandra Kausche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Kausche","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070224662","display_name":"Susanne Weber","orcid":"https://orcid.org/0000-0001-7209-8842","observed_orcids":["https://orcid.org/0000-0001-7209-8842"]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Weber","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044558629","display_name":"An Berges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Berges","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories bvba, Grauwmeer 14, 3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories bvba, Grauwmeer 14, 3001 Leuven, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045431517","display_name":"Markus Stueber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Stueber","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Muench","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Muench","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026898659","display_name":"Edgar Trelles-Sticken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Trelles-Sticken","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057258792","display_name":"J Pype","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Pype","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories bvba, Grauwmeer 14, 3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories bvba, Grauwmeer 14, 3001 Leuven, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005851593","display_name":"K Kohlgrueber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Kohlgrueber","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016082417","display_name":"H Voelkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Voelkel","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083520464","display_name":"Sandra Wittke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114941","display_name":"Philip Morris International (Germany)","ror":"https://ror.org/022jdjx35","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088192","https://openalex.org/I4210114941"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Wittke","raw_affiliation_strings":["Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr. 3, 51149 Cologne, Germany","institution_ids":["https://openalex.org/I4210114941"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.542,"has_fulltext":true,"cited_by_count":121,"citation_normalized_percentile":{"value":0.98934526,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"25","issue":"1","first_page":"316","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3r4f-cigarette","display_name":"3R4F cigarette","score":0.972000002861023},{"id":"https://openalex.org/keywords/tar-yield","display_name":"tar yield","score":0.4830000102519989},{"id":"https://openalex.org/keywords/nicotine-yield","display_name":"nicotine yield","score":0.746999979019165},{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nose-only-inhalation","display_name":"nose-only inhalation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rat-toxicity","display_name":"rat toxicity","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C129990765","wikidata":"https://www.wikidata.org/wiki/Q7508482","display_name":"Sidestream smoke","level":3,"score":0.8317618370056152},{"id":"https://openalex.org/C192643346","wikidata":"https://www.wikidata.org/wiki/Q283579","display_name":"tar (computing)","level":2,"score":0.7081843614578247},{"id":"https://openalex.org/C58874564","wikidata":"https://www.wikidata.org/wiki/Q130768","display_name":"Smoke","level":2,"score":0.6716041564941406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6601895093917847},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6584470868110657},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6361774206161499},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6255468726158142},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.5908490419387817},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4720248281955719},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41445279121398926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22420671582221985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19979986548423767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14032912254333496},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.137262225151062},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1157519519329071},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07527533173561096},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2478/cttr-2013-0912","doi":"https://doi.org/10.2478/cttr-2013-0912","is_oa":true,"landing_page_url":"https://doi.org/10.2478/cttr-2013-0912","pdf_url":"https://www.sciendo.com/pdf/10.2478/cttr-2013-0912","source":{"id":"https://openalex.org/S4210208843","display_name":"Beitr\u00e4ge zur Tabakforschung international","issn_l":"0173-783X","issn":["0173-783X","1612-9237"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beitr\u00e4ge zur Tabakforschung International/Contributions to Tobacco Research","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:039d0b99a33842cea947c1234872f69f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/039d0b99a33842cea947c1234872f69f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Beitr\u00e4ge zur Tabakforschung International, Vol 25, Iss 1, Pp 316-335 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2478/cttr-2013-0912","doi":"https://doi.org/10.2478/cttr-2013-0912","is_oa":true,"landing_page_url":"https://doi.org/10.2478/cttr-2013-0912","pdf_url":"https://www.sciendo.com/pdf/10.2478/cttr-2013-0912","source":{"id":"https://openalex.org/S4210208843","display_name":"Beitr\u00e4ge zur Tabakforschung international","issn_l":"0173-783X","issn":["0173-783X","1612-9237"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beitr\u00e4ge zur Tabakforschung International/Contributions to Tobacco Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W974199181.pdf","grobid_xml":"https://content.openalex.org/works/W974199181.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1540423631","https://openalex.org/W1886989480","https://openalex.org/W1970264991","https://openalex.org/W1975414280","https://openalex.org/W1980737380","https://openalex.org/W1982946819","https://openalex.org/W1983428212","https://openalex.org/W1983755215","https://openalex.org/W1988475207","https://openalex.org/W1989942090","https://openalex.org/W1998423913","https://openalex.org/W1999365155","https://openalex.org/W2004563532","https://openalex.org/W2004672141","https://openalex.org/W2005156172","https://openalex.org/W2006614620","https://openalex.org/W2010032115","https://openalex.org/W2011371303","https://openalex.org/W2013553950","https://openalex.org/W2018984280","https://openalex.org/W2023289473","https://openalex.org/W2024904679","https://openalex.org/W2026403707","https://openalex.org/W2033541386","https://openalex.org/W2038000594","https://openalex.org/W2039249065","https://openalex.org/W2043427030","https://openalex.org/W2074959816","https://openalex.org/W2079329009","https://openalex.org/W2091817329","https://openalex.org/W2094842178","https://openalex.org/W2098167307","https://openalex.org/W2100468039","https://openalex.org/W2108783072","https://openalex.org/W2118418527","https://openalex.org/W2121162548","https://openalex.org/W2121734990","https://openalex.org/W2126280736","https://openalex.org/W2127363280","https://openalex.org/W2132348364","https://openalex.org/W2148770756","https://openalex.org/W2159981521","https://openalex.org/W2162116567","https://openalex.org/W2165203405","https://openalex.org/W2198329211","https://openalex.org/W2326704507","https://openalex.org/W4245180255","https://openalex.org/W4248803784","https://openalex.org/W4252703263","https://openalex.org/W6602145743"],"related_works":["https://openalex.org/W2916002295","https://openalex.org/W3150450610","https://openalex.org/W1995384693","https://openalex.org/W2079329009","https://openalex.org/W3093214299","https://openalex.org/W2041306481","https://openalex.org/W2052492048","https://openalex.org/W2068661706","https://openalex.org/W2074959816","https://openalex.org/W2136101645"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"new":[2],"reference":[3,34,131,287],"cigarette,":[4],"the":[5,12,16,32,37,57,66,74,90,95,101,119,129,135,155,165,181,192,205,234,239,250,258,265,268,283],"3R4F,":[6],"has":[7],"been":[8],"developed":[9],"to":[10,24,47,117,170,204],"replace":[11],"depleting":[13],"supply":[14],"of":[15,31,56,125,138,208,219,236],"2R4F":[17,182,284],"cigarette.":[18,226],"The":[19,81,123,189],"present":[20,269],"study":[21,112,270],"was":[22,87,115,254],"designed":[23],"compare":[25,49],"mainstream":[26,50],"smoke":[27,51,126,150,173,209,273],"chemistry":[28,52,127,274],"and":[29,46,53,73,85,100,147,160,183,221,238,275,278,285],"toxicity":[30,163,242,281],"two":[33,61,130,259],"cigarettes":[35,132],"under":[36,213,246],"International":[38],"Organization":[39],"for":[40,191,282],"Standardization":[41],"(ISO)":[42],"machine":[43,67,260],"smoking":[44,63,68,79,196,261],"conditions,":[45,215,248],"further":[48],"toxicological":[54,187,223],"activity":[55,224,253],"3R4F":[58,184,193,286],"cigarette":[59,194,212],"by":[60,71,195],"different":[62,256],"regimens,":[64],"i.e.,":[65],"conditions":[69],"specified":[70],"ISO":[72],"Health":[75],"Canada":[76],"intensive":[77],"(HCI)":[78],"conditions.":[80,262],"in":[82,89,113,120,156,161,240,251,276,279],"vitro":[83,157,241,277],"cytotoxicity":[84],"mutagenicity":[86],"determined":[88],"neutral":[91],"red":[92],"uptake":[93],"assay,":[94,99],"Salmonella":[96],"reverse":[97],"mutation":[98],"mouse":[102],"lymphoma":[103],"thymidine":[104],"kinase":[105],"assay.":[106],"Additionally,":[107],"a":[108,200],"90-day":[109],"nose-only":[110],"inhalation":[111],"rats":[114],"conducted":[116],"assess":[118],"vivo":[121,162,252,280],"toxicity.":[122],"comparison":[124],"between":[128,180,257],"found":[133,198],"practically":[134],"same":[136],"yields":[137],"total":[139],"particulate":[140],"matter":[141],"(TPM),":[142],"\u2018tar\u2019,":[143,231],"nicotine,":[144,233],"carbon":[145],"monoxide,":[146],"most":[148],"other":[149],"constituents.":[151],"For":[152],"both":[153],"cigarettes,":[154],"cytotoxicity,":[158],"mutagenicity,":[159],"showed":[164],"expected":[166],"smoke-related":[167],"effects":[168],"compared":[169],"controls":[171],"without":[172],"exposure.":[174],"There":[175],"were":[176,243],"no":[177],"meaningful":[178],"differences":[179],"regarding":[185],"these":[186],"endpoints.":[188],"assessments":[190],"regimen":[197],"as":[199,264],"trivial":[201],"effect,":[202],"due":[203],"higher":[206,222],"amount":[207],"generated":[210],"per":[211,225,228],"HCI":[214,247],"an":[216],"increased":[217],"yield":[218],"toxicant":[220],"However,":[227],"mg":[229],"TPM,":[230],"or":[232],"amounts":[235],"toxicants":[237],"generally":[244],"lower":[245],"but":[249],"not":[255],"Overall,":[263],"main":[266],"result,":[267],"suggests":[271],"equivalent":[272],"cigarettes.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}