{"id":"https://openalex.org/W9737745","doi":null,"title":"Abstract 12821: Short Interfering RNA-Mediated Knockdown Of Glucose-6-Phosphate Dehydrogenase Impairs Cardiac Contractile Performance and Efficiency in Conscious Dogs","display_name":"Abstract 12821: Short Interfering RNA-Mediated Knockdown Of Glucose-6-Phosphate Dehydrogenase Impairs Cardiac Contractile Performance and Efficiency in Conscious Dogs","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W9737745","mag":"9737745"},"language":"en","primary_location":{"id":"mag:9737745","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/cgi/content/meeting_abstract/124/21_MeetingAbstracts/A12821","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027204721","display_name":"Claudio Vimercati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Vimercati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022171826","display_name":"Khaled Qanud","orcid":"https://orcid.org/0000-0003-2943-1245","observed_orcids":["https://orcid.org/0000-0003-2943-1245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khaled Qanud","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2943-1245","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103477772","display_name":"Rakhee S. Gupte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rakhee Gupte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082148261","display_name":"Neel S Patel","orcid":"https://orcid.org/0000-0003-0918-4857","observed_orcids":["https://orcid.org/0000-0003-0918-4857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neel Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0918-4857","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rahim Khan","orcid":"https://orcid.org/0000-0002-4840-6005","observed_orcids":["https://orcid.org/0000-0002-4840-6005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rahim Khan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4840-6005","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael A. Pfeffer","orcid":"https://orcid.org/0000-0002-8958-0843","observed_orcids":["https://orcid.org/0000-0002-8958-0843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Pfeffer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8958-0843","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012812911","display_name":"Margherita Maioli","orcid":"https://orcid.org/0000-0003-0187-4968","observed_orcids":["https://orcid.org/0000-0003-0187-4968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margherita Maioli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0187-4968","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103983742","display_name":"Eugene A. Cioffi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene A. Cioffi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033512267","display_name":"Sachin A. Gupte","orcid":"https://orcid.org/0000-0001-7453-8303","observed_orcids":["https://orcid.org/0000-0001-7453-8303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sachin A. Gupte","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7453-8303","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009822156","display_name":"Fabio A. Recchia","orcid":"https://orcid.org/0000-0002-4189-8465","observed_orcids":["https://orcid.org/0000-0002-4189-8465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabio A. Recchia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4189-8465","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"21","first_page":"12821","last_page":"12821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.3659999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.3659999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.319599986076355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-6-phosphate-dehydrogenase","display_name":"glucose-6-phosphate dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oxidative-pentose-phosphate-pathway","display_name":"oxidative pentose phosphate pathway","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiac-efficiency","display_name":"cardiac efficiency","score":0.7459999918937683},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/conscious-dogs","display_name":"conscious dogs","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8801818490028381},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7843281030654907},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5150575637817383},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.44528383016586304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4101814329624176},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.40029531717300415},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3747120499610901},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33883965015411377},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3336107134819031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26160699129104614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1700669825077057},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.15650495886802673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0764797031879425}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:9737745","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/cgi/content/meeting_abstract/124/21_MeetingAbstracts/A12821","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6987056164","https://openalex.org/W1983077804","https://openalex.org/W2549340877","https://openalex.org/W2147800318","https://openalex.org/W4237861064","https://openalex.org/W2019233854","https://openalex.org/W2136896439","https://openalex.org/W6998603213","https://openalex.org/W2026280715","https://openalex.org/W2027431265"],"abstract_inverted_index":{"The":[0],"oxidative":[1],"pentose":[2],"phosphate":[3],"pathway":[4],"(oxPPP)":[5],"generates":[6],"cytosolic":[7],"NADPH":[8],"and":[9,18],"has":[10],"been":[11],"found":[12],"critically":[13],"important":[14],"for":[15],"redox":[16],"homeostasis":[17],"function":[19],"of":[20],"isolated":[21],"cardiomyocytes.":[22],"However,":[23],"no":[24],"studies":[25],"...":[26]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}