{"id":"https://openalex.org/W973545616","doi":null,"title":"Targeting the genes of 9p13.3 amplicon in prostate cancer","display_name":"Targeting the genes of 9p13.3 amplicon in prostate cancer","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W973545616","mag":"973545616"},"language":"en","primary_location":{"id":"pmh:oai:trepo.tuni.fi:10024/96816","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/96816","pdf_url":"https://trepo.tuni.fi/handle/10024/96816","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Pro gradu -tutkielma | en=Master's thesis|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://trepo.tuni.fi/handle/10024/96816","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056842291","display_name":"Teemu Gr\u00f6nlund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Teemu Gr\u00f6nlund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056842291"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/chromosomal-amplification","display_name":"chromosomal amplification","score":0.7049999833106995},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8050000071525574},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.656000018119812},{"id":"https://openalex.org/keywords/target-genes","display_name":"target genes","score":0.6309999823570251},{"id":"https://openalex.org/keywords/fancg","display_name":"FANCG","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stoml2","display_name":"STOML2","score":1.0},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7630000114440918},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.7715564966201782},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7143689393997192},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46139904856681824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4579888582229614},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39644190669059753},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3912821412086487},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34055373072624207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31448832154273987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26839184761047363},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.12986627221107483}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:trepo.tuni.fi:10024/96816","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/96816","pdf_url":"https://trepo.tuni.fi/handle/10024/96816","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Pro gradu -tutkielma | en=Master's thesis|"},{"id":"pmh:oai:tampub.uta.fi:10024/96816","doi":null,"is_oa":false,"landing_page_url":"http://tampub.uta.fi/handle/10024/96816","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"fi=Pro gradu -tutkielma | en=Master's thesis|"},{"id":"mag:973545616","doi":null,"is_oa":false,"landing_page_url":"https://trepo.tuni.fi/handle/10024/96816","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:trepo.tuni.fi:10024/96816","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/96816","pdf_url":"https://trepo.tuni.fi/handle/10024/96816","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Pro gradu -tutkielma | en=Master's thesis|"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322592","display_name":"Tampereen Yliopisto","ror":"https://ror.org/033003e23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W973545616.pdf","grobid_xml":"https://content.openalex.org/works/W973545616.grobid-xml"},"referenced_works_count":175,"referenced_works":["https://openalex.org/W120409319","https://openalex.org/W1520066951","https://openalex.org/W1526016744","https://openalex.org/W1537016982","https://openalex.org/W1547654062","https://openalex.org/W1553178519","https://openalex.org/W1563832763","https://openalex.org/W1580150455","https://openalex.org/W1756163728","https://openalex.org/W1757407923","https://openalex.org/W1828013187","https://openalex.org/W1901333917","https://openalex.org/W1914047148","https://openalex.org/W1943652800","https://openalex.org/W1951189073","https://openalex.org/W1964252337","https://openalex.org/W1966522008","https://openalex.org/W1967222077","https://openalex.org/W1967304777","https://openalex.org/W1968302410","https://openalex.org/W1971659365","https://openalex.org/W1971765692","https://openalex.org/W1972437632","https://openalex.org/W1972912717","https://openalex.org/W1975577875","https://openalex.org/W1980269624","https://openalex.org/W1980670360","https://openalex.org/W1981989535","https://openalex.org/W1982868234","https://openalex.org/W1987439849","https://openalex.org/W1988428525","https://openalex.org/W1990236447","https://openalex.org/W1990347487","https://openalex.org/W1995367627","https://openalex.org/W1996487270","https://openalex.org/W1999343166","https://openalex.org/W2001526641","https://openalex.org/W2001928302","https://openalex.org/W2002314865","https://openalex.org/W2002384741","https://openalex.org/W2002530529","https://openalex.org/W2003371342","https://openalex.org/W2004375540","https://openalex.org/W2005741874","https://openalex.org/W2005841299","https://openalex.org/W2008183439","https://openalex.org/W2008640176","https://openalex.org/W2010691380","https://openalex.org/W2011957420","https://openalex.org/W2017329417","https://openalex.org/W2018825948","https://openalex.org/W2019387053","https://openalex.org/W2022227920","https://openalex.org/W2022635468","https://openalex.org/W2022667041","https://openalex.org/W2023006132","https://openalex.org/W2023560061","https://openalex.org/W2027424913","https://openalex.org/W2027954222","https://openalex.org/W2027988966","https://openalex.org/W2028716069","https://openalex.org/W2029971664","https://openalex.org/W2030621748","https://openalex.org/W2030996195","https://openalex.org/W2031439729","https://openalex.org/W2032019813","https://openalex.org/W2032353251","https://openalex.org/W2033620247","https://openalex.org/W2035397440","https://openalex.org/W2036256995","https://openalex.org/W2036929827","https://openalex.org/W2037564713","https://openalex.org/W2037852023","https://openalex.org/W2037886449","https://openalex.org/W2041665769","https://openalex.org/W2041686632","https://openalex.org/W2044315590","https://openalex.org/W2046558067","https://openalex.org/W2049984303","https://openalex.org/W2051025382","https://openalex.org/W2053304050","https://openalex.org/W2053548194","https://openalex.org/W2054823635","https://openalex.org/W2054923884","https://openalex.org/W2056903887","https://openalex.org/W2058387263","https://openalex.org/W2059300246","https://openalex.org/W2060739426","https://openalex.org/W2064077305","https://openalex.org/W2064629375","https://openalex.org/W2066213138","https://openalex.org/W2066857132","https://openalex.org/W2068752797","https://openalex.org/W2076830851","https://openalex.org/W2077299228","https://openalex.org/W2078239104","https://openalex.org/W2082823320","https://openalex.org/W2083274861","https://openalex.org/W2085667285","https://openalex.org/W2086152285","https://openalex.org/W2088792944","https://openalex.org/W2091481108","https://openalex.org/W2092117452","https://openalex.org/W2092172518","https://openalex.org/W2093889847","https://openalex.org/W2095059750","https://openalex.org/W2095804402","https://openalex.org/W2097774235","https://openalex.org/W2098694310","https://openalex.org/W2100932663","https://openalex.org/W2101675014","https://openalex.org/W2103002602","https://openalex.org/W2103526359","https://openalex.org/W2103792213","https://openalex.org/W2104400024","https://openalex.org/W2104957891","https://openalex.org/W2105460321","https://openalex.org/W2107277218","https://openalex.org/W2107633226","https://openalex.org/W2107726313","https://openalex.org/W2107903949","https://openalex.org/W2109948920","https://openalex.org/W2110848383","https://openalex.org/W2115447984","https://openalex.org/W2117905749","https://openalex.org/W2117991391","https://openalex.org/W2118055719","https://openalex.org/W2118087508","https://openalex.org/W2119212619","https://openalex.org/W2119391023","https://openalex.org/W2121158863","https://openalex.org/W2122769974","https://openalex.org/W2123573900","https://openalex.org/W2125941911","https://openalex.org/W2130875528","https://openalex.org/W2132024988","https://openalex.org/W2132783596","https://openalex.org/W2133228804","https://openalex.org/W2135798683","https://openalex.org/W2136452881","https://openalex.org/W2136988344","https://openalex.org/W2137547257","https://openalex.org/W2137679247","https://openalex.org/W2139966272","https://openalex.org/W2140649141","https://openalex.org/W2141077390","https://openalex.org/W2143146123","https://openalex.org/W2145684092","https://openalex.org/W2146965174","https://openalex.org/W2148416479","https://openalex.org/W2149046539","https://openalex.org/W2149485430","https://openalex.org/W2150173948","https://openalex.org/W2151737316","https://openalex.org/W2158003869","https://openalex.org/W2159448513","https://openalex.org/W2159715390","https://openalex.org/W2159955926","https://openalex.org/W2162147642","https://openalex.org/W2162729480","https://openalex.org/W2164092182","https://openalex.org/W2166037178","https://openalex.org/W2166267427","https://openalex.org/W2167609397","https://openalex.org/W2167749314","https://openalex.org/W2168839045","https://openalex.org/W2170641343","https://openalex.org/W2172042768","https://openalex.org/W2289145343","https://openalex.org/W2334096923","https://openalex.org/W2394940531","https://openalex.org/W2487343740","https://openalex.org/W2599229230","https://openalex.org/W7005733820","https://openalex.org/W7098629088"],"related_works":["https://openalex.org/W2004009571","https://openalex.org/W2342926750","https://openalex.org/W1273494532","https://openalex.org/W1973126977","https://openalex.org/W2317481010","https://openalex.org/W2145738531","https://openalex.org/W2599229230","https://openalex.org/W2119456291","https://openalex.org/W2004173365","https://openalex.org/W1806087494"],"abstract_inverted_index":{"Background":[0],"and":[1,13,53,64,84,107,127,134,175,178,193,210,232,236,246,253,266,291,297,305],"aims:":[2],"Prostate":[3,25],"cancer":[4,9,26,40,52,124,143,159,243,261,309,329],"is":[5,27,47],"the":[6,14,19,56,60,219,249,315,331],"most":[7],"common":[8],"among":[10],"men":[11],"worldwide,":[12],"molecular":[15],"mechanisms":[16],"involved":[17],"in":[18,50,68,97,142,285,330],"disease":[20],"still":[21],"remain":[22,268,300],"poorly":[23],"understood.":[24],"commonly":[28],"associated":[29,41,54],"with":[30,55,140,147,162,189,204],"genomic":[31],"copy":[32,149,206],"number":[33,150,207],"alterations":[34],"that":[35,92],"have":[36],"helped":[37],"to":[38,103,287,293,308],"identify":[39],"target":[42,90,120,153,163,216,271,318],"genes.":[43],"9p13.3":[44,72,88,209,274,316],"chromosomal":[45],"region":[46,73],"recurrently":[48],"amplified":[49],"prostate":[51,98,294,328],"aggressive":[57],"form":[58],"of":[59,113,119,208,218,273,278,314],"disease,":[61],"higher":[62],"PSA-level,":[63],"poor":[65],"progression-free":[66],"survival":[67],"prostatectomy":[69],"treated":[70],"patients.":[71],"may":[74,320],"harbor":[75],"one":[76],"or":[77,324],"more":[78],"novel":[79],"oncogenes.":[80],"NOL6,":[81,231],"C9orf23,":[82,229],"FANCG,":[83,230],"STOML2":[85,254,298],"are":[86,110],"possible":[87,117,302],"amplicon":[89,317],"genes":[91,109,154,223,272,280,299],"exhibit":[93],"elevated":[94,200],"gene":[95,121,136,164,201,217,255,319],"expression":[96,137,202],"cancer.":[99,295],"Our":[100],"aim":[101],"was":[102,138,170,211],"investigate":[104],"whether":[105],"NFX1":[106,133],"KIF24":[108,135,198],"also":[111,130],"part":[112],"this":[114],"group.":[115],"The":[116,182,221],"effects":[118,183],"silencing":[122,256],"on":[123,184,242,260],"cell":[125,144,160,168,185,244,262],"proliferation":[126,169,245],"migration":[128,186],"were":[129,155,187,228],"studied.":[131],"Methods:":[132],"studied":[139,188],"RT-qPCR":[141],"lines":[145,161],"xenografts":[146],"different":[148],"status.":[151],"Putative":[152],"silenced":[156],"by":[157,172,176],"trans-fecting":[158],"specific":[165],"siRNAs.":[166],"Cancer":[167],"as-sessed":[171],"AlamarBlue":[173],"assay":[174,192],"microscopy":[177],"digital":[179,194],"image":[180,195],"analysis.":[181,196],"wound":[190],"healing":[191],"Results:":[197],"exhibited":[199],"correlating":[203],"increased":[205],"therefore":[212],"selected":[213],"as":[214,269,301],"putative":[215,270],"amplicon.":[220,275],"other":[222,250],"outlined":[224],"for":[225,327],"our":[226],"study":[227],"STOML2.":[233],"Silencing":[234],"C9orf23":[235,265],"NOL6":[237,267],"had":[238,257],"a":[239],"negative":[240],"effect":[241,259],"migration.":[247],"On":[248],"hand,":[251],"FANCG":[252,296],"positive":[258],"proliferation.":[263],"Conclusion:":[264],"Further":[276],"investigations":[277],"these":[279],"should":[281],"be":[282],"carried":[283],"out":[284],"order":[286],"conclude":[288],"their":[289,306],"function":[290],"contribution":[292,307],"tumor":[303],"sup-pressors,":[304],"needs":[310],"further":[311],"clarification.":[312],"Confirmation":[313],"provide":[321],"new":[322],"prognostic":[323],"diagnostic":[325],"marker":[326],"future.":[332]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
