{"id":"https://openalex.org/W972931135","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1472-a","title":"Abstract P123: Vasopressin, but not Norepinephrine, causes Ventriculoarterial Mismatch in Experimental Post Ischemic Cardiogenic Shock","display_name":"Abstract P123: Vasopressin, but not Norepinephrine, causes Ventriculoarterial Mismatch in Experimental Post Ischemic Cardiogenic Shock","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W972931135","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1472-a","mag":"972931135"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_1472-a","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1472-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1472-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003141541","display_name":"Ole-Jakob How","orcid":"https://orcid.org/0000-0003-1495-0413","observed_orcids":["https://orcid.org/0000-0003-1495-0413"]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ole-Jakob How","raw_affiliation_strings":["Univ Hosp North Norway, Tromso, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Hosp North Norway, Tromso, Norway","institution_ids":["https://openalex.org/I1298853749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013407563","display_name":"Assami R\u00f6sner","orcid":"https://orcid.org/0000-0001-9084-5805","observed_orcids":["https://orcid.org/0000-0001-9084-5805"]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Assami R\u00f8sner","raw_affiliation_strings":["Univ Hosp North Norway, Tromso, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Hosp North Norway, Tromso, Norway","institution_ids":["https://openalex.org/I1298853749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063067805","display_name":"Petter Fosse Gjessing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Petter Gjessing","raw_affiliation_strings":["Univ Hosp North Norway, Tromso, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Hosp North Norway, Tromso, Norway","institution_ids":["https://openalex.org/I1298853749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085230256","display_name":"Stig Eggen Hermansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Stig E Hermansen","raw_affiliation_strings":["Univ Hosp North Norway, Tromso, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Hosp North Norway, Tromso, Norway","institution_ids":["https://openalex.org/I1298853749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017115516","display_name":"Truls Myrmel","orcid":"https://orcid.org/0000-0002-4148-9223","observed_orcids":["https://orcid.org/0000-0002-4148-9223"]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Truls Myrmel","raw_affiliation_strings":["Univ Hosp North Norway, Tromso, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Hosp North Norway, Tromso, Norway","institution_ids":["https://openalex.org/I1298853749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1298853749"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiogenic-shock","display_name":"cardiogenic shock","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ventricular-arterial-coupling","display_name":"ventricular-arterial coupling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/inodilators","display_name":"inodilators","score":0.5009999871253967},{"id":"https://openalex.org/keywords/dobutamine","display_name":"dobutamine","score":0.7789999842643738},{"id":"https://openalex.org/keywords/coronary-microembolization","display_name":"coronary microembolization","score":0.9190000295639038},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.7149999737739563},{"id":"https://openalex.org/keywords/preload-recruitable-stroke-work","display_name":"preload recruitable stroke work","score":0.8820000290870667},{"id":"https://openalex.org/keywords/elastance","display_name":"elastance","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.6909999847412109},{"id":"https://openalex.org/keywords/vasopressor-support","display_name":"vasopressor therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.5870000123977661},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2781185063","wikidata":"https://www.wikidata.org/wiki/Q422782","display_name":"Dobutamine","level":3,"score":0.83484947681427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8301351070404053},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6660143136978149},{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.6618300080299377},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.6590240001678467},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6494524478912354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6036521196365356},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5496701002120972},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4980781078338623},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.4978334903717041},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.4836064875125885},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.4686174988746643},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.46053457260131836},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.45611709356307983},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.4526788890361786},{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.42987972497940063},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.32027506828308105},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.264375239610672},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.23668867349624634},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.06475597620010376}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_1472-a","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1472-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1472-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2067022854","https://openalex.org/W2279761229","https://openalex.org/W4212784980","https://openalex.org/W3029743479","https://openalex.org/W2320849083","https://openalex.org/W3211425974","https://openalex.org/W2077455039","https://openalex.org/W2949115330","https://openalex.org/W2011416633","https://openalex.org/W3012643941"],"abstract_inverted_index":{"Introduction":[0],"In":[1,52,80,111,170,209,330],"agreement":[2],"with":[3,67,204,364],"existing":[4],"guidelines,":[5],"inotropic":[6],"and":[7,28,44,65,103,105,129,139,166,184,230,248,263,278,292,299,308,325,345],"vasopressor":[8,76],"support":[9],"is":[10,19],"given":[11,35],"routinely":[12],"in":[13,36,177,198,207,315,360],"cardiogenic":[14,37,365],"shock":[15,38,286,336,366,369],"(CS).":[16],"However,":[17],"there":[18],"a":[20,53,74,123,316,373],"lack":[21],"of":[22,30,127,319],"scientific":[23],"evidence":[24],"supporting":[25],"the":[26,41,60,106,112,216,219,285,335,368],"efficacy":[27],"safety":[29],"such":[31],"treatment.":[32],"Hypothesis":[33],"Vasoconstrictors":[34],"will":[39],"increase":[40,197],"ventriculoarterial":[42,107,118,374],"mismatch":[43],"thus":[45],"lead":[46],"to":[47,135,150,162,191,218,303,351],"reduced":[48],"cardiac":[49,289],"output":[50,290],"Methods":[51],"closed":[54],"chest":[55],"pig":[56],"model":[57],"we":[58],"tested":[59],"inodilator":[61],"(dobutamine,":[62],"Dobut)":[63],"alone":[64,193],"combined":[66],"either":[68],"an":[69,140,178],"inoconstrictor":[70],"(norepinephrine,":[71],"NE)":[72],"or":[73],"pure":[75,356],"(arginine":[77],"vasopressin,":[78],"AVP).":[79],"anesthetized":[81],"animals,":[82],"CS":[83],"was":[84,155,237],"induced":[85],"by":[86,96,158,240,253,287,338,371],"coronary":[87],"microembolization":[88],"under":[89],"fluoroscopic":[90],"guidance.":[91],"Hemodynamic":[92],"indices":[93],"were":[94],"obtained":[95],"Swan-Ganz":[97],"catheters,":[98],"left":[99],"ventricular":[100,130],"pressure-volume":[101],"catheters":[102],"echocardiography,":[104],"coupling":[108],"calculated.":[109],"Results":[110],"normal":[113],"heart,":[114],"Dobut":[115,192,241,283,352],"(2ug/kg/min)":[116],"enhanced":[117,157],"energy":[119,213],"transfer,":[120],"shown":[121],"as":[122],"decreased":[124,185],"Ea/Ees":[125,180],"(ratio":[126],"arterial":[128,220],"elastance),":[131],"1.0":[132],"\u00b1":[133,137,148,152,164,168,182,188,224,228,234,243,246,250,258,261,265,273,276,280,296,301,305,310,322,328,342,348],"0.1":[134,165],"0.8":[136],"0.1,":[138,274],"increased":[141,179],"preload":[142],"recruitable":[143],"stroke":[144],"work":[145],"(PRSW),":[146],"53":[147,260],"5":[149],"63":[151],"2.":[153],"This":[154],"further":[156,254,317,333],"NE":[159,256,313],"(100":[160],"ng/kg/min)":[161],"0.7":[163],"79":[167],"6.":[169],"contrast,":[171],"adding":[172,255,270],"AVP":[173,271,332],"(0.001":[174],"u/kg/min)":[175],"resulted":[176,314],"(1.0":[181],"0.1)":[183],"PRSW":[186,226],"(56":[187],"8)":[189],"compared":[190,350],"(a":[194],"two":[195],"fold":[196],"systemic":[199],"vascular":[200],"resistance":[201],"(SVR),":[202],"concomitant":[203],"no":[205],"elevation":[206],"contractility).":[208],"post":[210],"ischemic":[211,362],"CS,":[212],"transfer":[214],"from":[215,294],"ventricle":[217],"system":[221],"(Ea/Ees":[222],"1.8":[223],"0.2,":[225,244,259],"26":[227],"2":[229,247,262],"Ejection":[231],"fraction":[232],"42":[233],"6":[235,343],"%)":[236],"partly":[238],"restored":[239],"(1.4":[242],"46":[245],"47":[249],"6%)":[251],"unaffected":[252],"(1.5":[257],"45":[264],"5%),":[266],"but":[267],"impaired":[268],"after":[269],"(2.0":[272],"43":[275],"1":[277],"34":[279],"4%).":[281,329],"Consequently,":[282],"improved":[284],"increasing":[288,358],"(CO)":[291],"SVO2":[293,326,346],"74":[295],"3":[297],"ml/kg":[298,307],"37":[300],"2%":[302],"103":[304],"8":[306],"49":[309],"3%.":[311],"Adding":[312],"improvement":[318],"CO":[320,340],"(125":[321],"9":[323],"ml/kg)":[324,344],"(59":[327],"contrast":[331],"worsened":[334],"state":[337,370],"decreasing":[339],"(70":[341],"(45":[347],"5%)":[349],"alone.":[353],"Conclusion":[354],"A":[355],"afterload":[357],"substance":[359],"acute":[361],"hearts":[363],"aggravate":[367],"causing":[372],"mismatch.":[375]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}