{"id":"https://openalex.org/W97174281","doi":null,"title":"Increased calcium levels alter cellular and molecular events in wound healing.","display_name":"Increased calcium levels alter cellular and molecular events in wound healing.","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W97174281","mag":"97174281","pmid":"https://pubmed.ncbi.nlm.nih.gov/2555928"},"language":"en","primary_location":{"id":"pmid:2555928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2555928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054520231","display_name":"Anthony C. Sank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Sank","raw_affiliation_strings":["Laboratory of Developmental Biology and Anomalies, National Institutes of Health, Bethesda, Md. 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Biology and Anomalies, National Institutes of Health, Bethesda, Md. 20892","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111213648","display_name":"M.M.Y. Chi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Chi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043384742","display_name":"Taro Shima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Shima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077653892","display_name":"Reuven Reich","orcid":"https://orcid.org/0000-0003-1684-5967","observed_orcids":["https://orcid.org/0000-0003-1684-5967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Reich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"G R Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G R Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8755,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.88758495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"106","issue":"6","first_page":"1141","last_page":"7; discussion 1147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.8100000023841858},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9010000228881836},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9620000123977661},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.9079999923706055},{"id":"https://openalex.org/keywords/calcium-channel-blockade","display_name":"calcium channel blockade","score":0.8149999976158142},{"id":"https://openalex.org/keywords/wound-contraction","display_name":"wound contraction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/collagenase-activity","display_name":"collagenase activity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.8967583179473877},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.806304395198822},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7736366987228394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7352514266967773},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6379066109657288},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6215848922729492},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5660248398780823},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5569797158241272},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.5497661828994751},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5122775435447693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47373759746551514},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.4238508641719818},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3168269395828247},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.284198522567749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27913734316825867},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2705569863319397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2508968710899353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15544497966766357},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2555928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2555928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},{"id":"mag:97174281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2555928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1516836596","https://openalex.org/W1740638321","https://openalex.org/W1970516412","https://openalex.org/W1979552486","https://openalex.org/W2037107669","https://openalex.org/W2038085058","https://openalex.org/W2061873304","https://openalex.org/W2068270309","https://openalex.org/W2074585769","https://openalex.org/W2085352579","https://openalex.org/W2088233139","https://openalex.org/W2096400641"],"related_works":["https://openalex.org/W2082073167","https://openalex.org/W3175916258","https://openalex.org/W4405581646","https://openalex.org/W2160913995","https://openalex.org/W2189220773","https://openalex.org/W2027528955","https://openalex.org/W2110784260","https://openalex.org/W7100137199","https://openalex.org/W4300347751","https://openalex.org/W3088976608"],"abstract_inverted_index":{"Surgical":[0],"morbidity":[1],"is":[2],"dictated":[3],"directly":[4],"by":[5,64,127],"wound":[6,29,102,124,153],"healing.":[7],"We":[8,36],"have":[9],"studied":[10],"the":[11,25,39,67,115,158,168,188],"effects":[12],"of":[13,24,28,105,117,144,167,170,173,190],"elevated":[14,171],"calcium":[15,41,56,68,84,174],"levels":[16,172],"using":[17],"cultured":[18],"keratinocytes":[19],"in":[20,81,95,138,151,176,179,187],"vitro":[21,177],"on":[22,58,73,114],"two":[23],"rate-limiting":[26],"steps":[27],"healing,":[30],"chemotaxis":[31,48],"(directed":[32],"migration)":[33],"and":[34,49,160,178],"adhesion.":[35],"found":[37],"that":[38,119],"increased":[40,128],"(10":[42],"mmol/L)":[43],"significantly":[44,96],"inhibited":[45],"both":[46,175],"keratinocyte":[47],"adhesion":[50,59],"(p":[51,97,131],"less":[52,98,132],"than":[53,99,133],"0.05).":[54],"The":[55,122,142],"effect":[57],"could":[60],"be":[61],"partially":[62],"reversed":[63],"pretreatment":[65],"with":[66],"channel":[69],"blocker":[70],"verapamil.":[71],"Based":[72],"these":[74,147],"data,":[75],"an":[76],"animal":[77],"model":[78],"was":[79,87,125],"formulated":[80],"which":[82],"topical":[83],"(5":[85],"mmol/L/day)":[86],"added":[88],"to":[89,146],"linear":[90],"incision":[91],"wounds.":[92,192],"This":[93],"resulted":[94,150],"0.05)":[100,134],"delayed":[101],"contraction":[103,112],"characteristic":[104],"a":[106,165,184],"chronic":[107,123,148,191],"or":[108],"impaired":[109],"wound.":[110],"Wound":[111],"depends":[113],"presence":[116],"fibroblasts":[118],"synthesize":[120],"collagen.":[121],"characterized":[126],"collagenase":[129],"activity":[130],"but":[135],"little":[136],"alteration":[137],"collagen":[139],"I":[140],"synthesis.":[141],"addition":[143,169],"verapamil":[145],"wounds":[149],"improved":[152],"closure.":[154],"These":[155],"studies":[156],"define":[157],"molecular":[159],"cellular":[161],"events":[162],"occurring":[163],"as":[164],"result":[166],"vivo.":[180],"Calcium":[181],"may":[182],"play":[183],"key":[185],"role":[186],"pathogenesis":[189]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
