{"id":"https://openalex.org/W97172822","doi":null,"title":"The role of compartmentalized PKA signaling in hippocampal synaptic plasticity","display_name":"The role of compartmentalized PKA signaling in hippocampal synaptic plasticity","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W97172822","mag":"97172822"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:dissertations-8344","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3328581","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109401181","display_name":"Ted T. Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ted T. Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109401181"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.15410000085830688,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-synaptic-plasticity","display_name":"hippocampal synaptic plasticity","score":0.890999972820282},{"id":"https://openalex.org/keywords/a-kinase-anchoring-proteins","display_name":"A-kinase anchoring proteins","score":0.8330000042915344},{"id":"https://openalex.org/keywords/akap12","display_name":"AKAP12","score":0.9010000228881836},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6430000066757202},{"id":"https://openalex.org/keywords/synaptic-tagging-and-capture","display_name":"synaptic tagging and capture","score":0.7609999775886536},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.9710000157356262},{"id":"https://openalex.org/keywords/memory-storage","display_name":"memory storage","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.6836983561515808},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.6583302021026611},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6037732362747192},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.5892661213874817},{"id":"https://openalex.org/C26410512","wikidata":"https://www.wikidata.org/wiki/Q3906363","display_name":"Nonsynaptic plasticity","level":5,"score":0.5853596925735474},{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.5686427354812622},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5634415149688721},{"id":"https://openalex.org/C83119035","wikidata":"https://www.wikidata.org/wiki/Q17030659","display_name":"Homosynaptic plasticity","level":5,"score":0.4828987121582031},{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.47745540738105774},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.426314115524292},{"id":"https://openalex.org/C95293801","wikidata":"https://www.wikidata.org/wiki/Q7662035","display_name":"Synaptic augmentation","level":4,"score":0.41695892810821533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40531080961227417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3489871919155121},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13875612616539001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1358502209186554},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07455858588218689},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.upenn.edu:dissertations-8344","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3328581","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:97172822","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=8344&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2339559586","https://openalex.org/W2038001775","https://openalex.org/W2134316104","https://openalex.org/W2002950499","https://openalex.org/W1983581429","https://openalex.org/W2085331090","https://openalex.org/W2491725657","https://openalex.org/W2014388728","https://openalex.org/W1993135690","https://openalex.org/W3013864211"],"abstract_inverted_index":{"Synaptic":[0],"plasticity,":[1],"the":[2,6,20,29,66,113,124,130,139,170],"activity-dependent":[3],"change":[4],"in":[5,77,83,119,135,146],"strength":[7],"of":[8,16,27,31,39,43,69,98,115,132,142,172],"neuronal":[9],"connections,":[10],"is":[11,45,88,107,154,166,179],"a":[12,23,84,108],"proposed":[13],"cellular":[14],"mechanism":[15,109],"memory":[17],"storage.":[18],"Despite":[19],"fact":[21],"that":[22,110,182],"neuron":[24],"contains":[25],"thousands":[26],"synapses,":[28],"expression":[30],"synaptic":[32,52,148,159,173,188],"plasticity":[33,53,160,189],"can":[34,80],"be":[35,81],"specific":[36],"to":[37,93,102,112],"subsets":[38],"synapses.":[40],"This":[41],"level":[42],"specificity":[44,79,114],"remarkable,":[46],"because":[47],"signal":[48,85],"transduction":[49,86],"pathways":[50],"underlying":[51,186],"involve":[54],"diffusible":[55],"second":[56],"messenger":[57],"molecules":[58,92],"such":[59,64],"as":[60,65],"cAMP":[61],"and":[62,137,161,175,190],"proteins":[63],"catalytic":[67],"subunit":[68],"PKA":[70,99,133,144,152,164],"(cyclic-AMP":[71],"dependent":[72],"protein":[73],"kinase).":[74],"One":[75],"way":[76],"which":[78],"achieved":[82],"system":[87],"by":[89],"confining":[90],"signaling":[91,117,153,185],"subcellular":[94],"domains.":[95],"Spatial":[96],"compartmentalization":[97],"via":[100],"binding":[101],"A-Kinase":[103],"Anchoring":[104],"Proteins":[105],"(AKAPs)":[106],"contributes":[111],"this":[116],"pathway":[118],"effecting":[120],"downstream":[121],"events.":[122],"In":[123],"following":[125],"chapters":[126],"I":[127],"will":[128],"discuss":[129],"roles":[131,141],"anchoring":[134,165],"neurons":[136],"highlight":[138],"functional":[140],"compartmentalizing":[143],"signals":[145],"hippocampal":[147,158,187],"plasticity.":[149],"Overall,":[150],"compartmentalized":[151,184],"critically":[155],"important":[156],"for":[157,169],"spatial":[162,191],"memory.":[163,192],"also":[167],"required":[168],"process":[171],"tagging":[174],"capture.":[176],"Finally,":[177],"AKAP12":[178],"an":[180],"AKAP":[181],"mediates":[183]},"counts_by_year":[],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2016-06-24T00:00:00"}