{"id":"https://openalex.org/W971267330","doi":"https://doi.org/10.1007/978-1-4612-5184-2_39","title":"Relationship of Inositol, Phosphatidylinositol and Phosphatidic Acid in CNS Nerve Endings","display_name":"Relationship of Inositol, Phosphatidylinositol and Phosphatidic Acid in CNS Nerve Endings","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W971267330","doi":"https://doi.org/10.1007/978-1-4612-5184-2_39","mag":"971267330"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4612-5184-2_39","doi":"https://doi.org/10.1007/978-1-4612-5184-2_39","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-5184-2_39","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inositol and Phosphoinositides","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2495607463","display_name":"Inositol and Phosphoinositides"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060110530","display_name":"John R. Yandrasitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. R. Yandrasitz","raw_affiliation_strings":["Division of Metabolism, Children\u2019s Hospital, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Children\u2019s Hospital, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011258397","display_name":"Gerard T. Berry","orcid":"https://orcid.org/0000-0001-5299-3313","observed_orcids":["https://orcid.org/0000-0001-5299-3313"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Berry","raw_affiliation_strings":["Division of Metabolism, Children\u2019s Hospital, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Children\u2019s Hospital, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113556670","display_name":"Stanton Segal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Segal","raw_affiliation_strings":["Division of Metabolism, Children\u2019s Hospital, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Children\u2019s Hospital, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1335321130"],"apc_list":null,"apc_paid":null,"fwci":0.4645,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55384615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"601","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.9649999737739563},{"id":"https://openalex.org/keywords/phosphatidylinositol","display_name":"phosphatidylinositol","score":0.996999979019165},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":1.0},{"id":"https://openalex.org/keywords/nerve-endings","display_name":"nerve endings","score":0.7260000109672546},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.7850000262260437},{"id":"https://openalex.org/keywords/inositol-transport","display_name":"inositol transport","score":0.7649999856948853},{"id":"https://openalex.org/keywords/phospholipid-metabolism","display_name":"phospholipid metabolism","score":0.7710000276565552},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.5270000100135803},{"id":"https://openalex.org/keywords/potassium","display_name":"potassium","score":0.9660000205039978},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.6029999852180481},{"id":"https://openalex.org/keywords/phosphatidic-acid-synthesis","display_name":"phosphatidic acid synthesis","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.8969404697418213},{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.8894879817962646},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.8188337087631226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6804777383804321},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.6698783040046692},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.6331679224967957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4670732319355011},{"id":"https://openalex.org/C2781387506","wikidata":"https://www.wikidata.org/wiki/Q138145","display_name":"Inositol trisphosphate","level":4,"score":0.46251168847084045},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.4466634690761566},{"id":"https://openalex.org/C2776387844","wikidata":"https://www.wikidata.org/wiki/Q161466","display_name":"Diglyceride","level":3,"score":0.4311855733394623},{"id":"https://openalex.org/C136357698","wikidata":"https://www.wikidata.org/wiki/Q3290037","display_name":"Free nerve ending","level":2,"score":0.41581711173057556},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.32818347215652466},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30293455719947815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17557355761528015},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.14261791110038757},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12612012028694153},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11034727096557617},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.09661084413528442},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4612-5184-2_39","doi":"https://doi.org/10.1007/978-1-4612-5184-2_39","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-5184-2_39","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inositol and Phosphoinositides","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1514712862","https://openalex.org/W1517710982","https://openalex.org/W1543617877","https://openalex.org/W1759379486","https://openalex.org/W1964573998","https://openalex.org/W1978541156","https://openalex.org/W1979598922","https://openalex.org/W1982903824","https://openalex.org/W1985546134","https://openalex.org/W1987934093","https://openalex.org/W1989592671","https://openalex.org/W2004581348","https://openalex.org/W2012667655","https://openalex.org/W2019935012","https://openalex.org/W2021633228","https://openalex.org/W2024479106","https://openalex.org/W2025432467","https://openalex.org/W2030664952","https://openalex.org/W2037459610","https://openalex.org/W2056597195","https://openalex.org/W2062743947","https://openalex.org/W2074452041","https://openalex.org/W2078853941","https://openalex.org/W2082661546","https://openalex.org/W2093804401","https://openalex.org/W2115662445","https://openalex.org/W2123992546","https://openalex.org/W2131182702","https://openalex.org/W2131210246","https://openalex.org/W2134904607","https://openalex.org/W2228511898","https://openalex.org/W2300139133"],"related_works":["https://openalex.org/W2122780688","https://openalex.org/W2066687664","https://openalex.org/W2187758487","https://openalex.org/W2080384040","https://openalex.org/W2069101785","https://openalex.org/W2049070841","https://openalex.org/W2024214948","https://openalex.org/W2153600832","https://openalex.org/W1514712862","https://openalex.org/W7099553456"],"abstract_inverted_index":{"Nerve":[0],"endings":[1],"were":[2,34,183],"prepared":[3],"from":[4,130,170],"rat":[5],"cerebra":[6],"by":[7,117,126,137,161,185],"differential":[8],"centrifugation":[9],"and":[10,15,24,31,53,157,178,209],"a":[11,78,162,171],"5-step":[12],"Ficoll":[13],"gradient,":[14],"challenged":[16],"with":[17,22,70,128,190],"several":[18],"agents":[19,217],"during":[20],"incubation":[21],"33PO4":[23,61,153],"[3H]inositol.":[25],"The":[26,102,176],"specific":[27,68,121,179],"radioactivities":[28,69],"of":[29,50,66,72,82,92,100,133,147,168,181,194],"phospholipids":[30],"free":[32],"inositol":[33,129,134,182],"determined":[35],"in":[36,144,188],"an":[37,138],"attempt":[38],"to":[39],"discern":[40],"the":[41,89,145,215,220],"metabolic":[42,227],"steps":[43],"which":[44],"are":[45],"responsible":[46],"for":[47],"increased":[48],"radiolabeling":[49,94,193],"phosphatidylinositol":[51],"(PI)":[52],"phosphatidic":[54],"acid":[55],"(PA).":[56],"While":[57],"ACh":[58,90,210],"greatly":[59,79,151],"stimulated":[60,104],"incorporation":[62,106,154],"into":[63,107,135,155],"PI,":[64,158],"comparison":[65],"PI":[67,83,108,136],"that":[71,99,214],"precursor":[73],"PA":[74,93,156],"did":[75],"not":[76,142,199],"indicate":[77],"enhanced":[80,152],"rate":[81],"synthesis.":[84],"In":[85],"low":[86],"calcium":[87],"buffers":[88],"stimulation":[91],"was":[95,115,123,198],"more":[96],"attenuated":[97],"than":[98,111,174],"PI.":[101,131],"neurotransmitter":[103],"[3H]inositol":[105],"much":[109],"less":[110],"33P04.":[112],"Inositol":[113],"transport":[114],"unaffected":[116],"ACh,":[118],"but":[119,159,224],"its":[120],"radioactivity":[122,180],"decreased,":[124],"partly":[125],"dilution":[127],"Incorporation":[132],"exchange":[139],"mechanism":[140],"vas":[141],"important":[143],"action":[146],"ACh.":[148],"Increasing":[149],"[K+]o":[150,208],"probably":[160],"$$C{{a}^{{{{2}^{":[163,202],"+":[164,203],"}}}}}$$":[165,204],"dependent":[166,200],"mobilization":[167],"diacylglycerol":[169],"lipid":[172],"other":[173],"these.":[175],"uptake":[177],"decreased":[184,191],"elevated":[186],"K+":[187],"parallel":[189],"3H":[192],"PI;":[195],"this":[196],"effect":[197],"on":[201],"or":[205],"Na+.":[206],"Elevated":[207],"acted":[211],"synergistically,":[212],"indicating":[213],"two":[216],"act":[218],"at":[219,225],"same":[221],"subcellular":[222],"sites":[223],"different":[226],"steps.":[228]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}