{"id":"https://openalex.org/W971141903","doi":null,"title":"Fluorescent Nucleobase Analogues and their use for Investigating DNA Interactions","display_name":"Fluorescent Nucleobase Analogues and their use for Investigating DNA Interactions","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W971141903","mag":"971141903"},"language":"en","primary_location":{"id":"pmh:oai:research.chalmers.se:197672","doi":null,"is_oa":true,"landing_page_url":"https://research.chalmers.se/en/publication/197672","pdf_url":"http://publications.lib.chalmers.se/records/fulltext/197672/197672.pdf","source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://publications.lib.chalmers.se/records/fulltext/197672/197672.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041522950","display_name":"Anke Dierckx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anke Dierckx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041522950"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-labeling","display_name":"DNA labeling","score":0.6140000224113464},{"id":"https://openalex.org/keywords/2-aminopurine","display_name":"2-aminopurine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tc","display_name":"Tc","score":0.453000009059906},{"id":"https://openalex.org/keywords/photophysical-properties","display_name":"photophysical properties","score":0.5299999713897705},{"id":"https://openalex.org/keywords/dna-duplex-stability","display_name":"DNA duplex stability","score":0.6129999756813049},{"id":"https://openalex.org/keywords/b-dna","display_name":"B-DNA","score":0.656000018119812},{"id":"https://openalex.org/keywords/major-groove","display_name":"major groove","score":0.5419999957084656},{"id":"https://openalex.org/keywords/photostability","display_name":"photostability","score":0.7459999918937683},{"id":"https://openalex.org/keywords/photoproducts","display_name":"photoproducts","score":0.7879999876022339},{"id":"https://openalex.org/keywords/fluorescence-resonance-energy-transfer","display_name":"fluorescence resonance energy transfer","score":0.6140000224113464},{"id":"https://openalex.org/keywords/mitochondrial-transcription","display_name":"mitochondrial transcription","score":0.9150000214576721},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C61234307","wikidata":"https://www.wikidata.org/wiki/Q422960","display_name":"Nucleobase","level":3,"score":0.9375604391098022},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7611217498779297},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6943148374557495},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5756758451461792},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5476866364479065},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.5356518626213074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5350241661071777},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5336920022964478},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.4847981035709381},{"id":"https://openalex.org/C2777907353","wikidata":"https://www.wikidata.org/wiki/Q903341","display_name":"Triazole","level":2,"score":0.43975675106048584},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3865976929664612},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32051175832748413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28235042095184326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20698463916778564},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.08865761756896973},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07497134804725647},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:research.chalmers.se:197672","doi":null,"is_oa":true,"landing_page_url":"https://research.chalmers.se/en/publication/197672","pdf_url":"http://publications.lib.chalmers.se/records/fulltext/197672/197672.pdf","source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:publications.lib.chalmers.se:197672","doi":null,"is_oa":false,"landing_page_url":"http://publications.lib.chalmers.se/publication/197672-fluorescent-nucleobase-analogues-and-their-use-for-investigating-dna-interactions","pdf_url":null,"source":{"id":"https://openalex.org/S4377196470","display_name":"Chalmers Publication Library (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text.Thesis.Doctoral"},{"id":"mag:971141903","doi":null,"is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/197672","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research.chalmers.se:197672","doi":null,"is_oa":true,"landing_page_url":"https://research.chalmers.se/en/publication/197672","pdf_url":"http://publications.lib.chalmers.se/records/fulltext/197672/197672.pdf","source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W971141903.pdf","grobid_xml":"https://content.openalex.org/works/W971141903.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W632135146","https://openalex.org/W1530449641","https://openalex.org/W1532212600","https://openalex.org/W1538202910","https://openalex.org/W1551656287","https://openalex.org/W1579716589","https://openalex.org/W1597095463","https://openalex.org/W1965464171","https://openalex.org/W1967121834","https://openalex.org/W1969508252","https://openalex.org/W1969509102","https://openalex.org/W1970300629","https://openalex.org/W1972622825","https://openalex.org/W1972645332","https://openalex.org/W1974427934","https://openalex.org/W1974955901","https://openalex.org/W1977619408","https://openalex.org/W1982243106","https://openalex.org/W1983797821","https://openalex.org/W1984140197","https://openalex.org/W1986588909","https://openalex.org/W1987741147","https://openalex.org/W1988937488","https://openalex.org/W1990802269","https://openalex.org/W1991190990","https://openalex.org/W1994021375","https://openalex.org/W1994221056","https://openalex.org/W1994607573","https://openalex.org/W1994892769","https://openalex.org/W1995629096","https://openalex.org/W1998974825","https://openalex.org/W1999344732","https://openalex.org/W1999814206","https://openalex.org/W2002091803","https://openalex.org/W2003233514","https://openalex.org/W2004435445","https://openalex.org/W2005240531","https://openalex.org/W2006967140","https://openalex.org/W2007153791","https://openalex.org/W2009646148","https://openalex.org/W2009771834","https://openalex.org/W2011107379","https://openalex.org/W2011862795","https://openalex.org/W2016825759","https://openalex.org/W2018448923","https://openalex.org/W2019636553","https://openalex.org/W2021028637","https://openalex.org/W2022494632","https://openalex.org/W2022846880","https://openalex.org/W2024304214","https://openalex.org/W2024349954","https://openalex.org/W2025738476","https://openalex.org/W2028461557","https://openalex.org/W2029443955","https://openalex.org/W2032250268","https://openalex.org/W2035685310","https://openalex.org/W2037151234","https://openalex.org/W2037205953","https://openalex.org/W2037903754","https://openalex.org/W2038271017","https://openalex.org/W2041199002","https://openalex.org/W2044169747","https://openalex.org/W2044348179","https://openalex.org/W2047956778","https://openalex.org/W2050218740","https://openalex.org/W2052433974","https://openalex.org/W2052715942","https://openalex.org/W2056230513","https://openalex.org/W2056476654","https://openalex.org/W2057666290","https://openalex.org/W2058435677","https://openalex.org/W2059223643","https://openalex.org/W2060410314","https://openalex.org/W2066420551","https://openalex.org/W2066533320","https://openalex.org/W2069259948","https://openalex.org/W2069464193","https://openalex.org/W2074898729","https://openalex.org/W2075172171","https://openalex.org/W2076473013","https://openalex.org/W2077850544","https://openalex.org/W2079650265","https://openalex.org/W2080450988","https://openalex.org/W2080643217","https://openalex.org/W2081360068","https://openalex.org/W2081397502","https://openalex.org/W2081930801","https://openalex.org/W2082280007","https://openalex.org/W2085954575","https://openalex.org/W2089938533","https://openalex.org/W2091751711","https://openalex.org/W2094146192","https://openalex.org/W2094517427","https://openalex.org/W2098246822","https://openalex.org/W2106769579","https://openalex.org/W2112568806","https://openalex.org/W2115316940","https://openalex.org/W2117208578","https://openalex.org/W2117226853","https://openalex.org/W2120687754","https://openalex.org/W2120813036","https://openalex.org/W2123206012","https://openalex.org/W2123281294","https://openalex.org/W2124050695","https://openalex.org/W2126342106","https://openalex.org/W2126466006","https://openalex.org/W2128172592","https://openalex.org/W2128479875","https://openalex.org/W2129995310","https://openalex.org/W2131970139","https://openalex.org/W2132677630","https://openalex.org/W2133296358","https://openalex.org/W2135532067","https://openalex.org/W2136698583","https://openalex.org/W2145325210","https://openalex.org/W2145962031","https://openalex.org/W2146933373","https://openalex.org/W2148919980","https://openalex.org/W2150531185","https://openalex.org/W2153594569","https://openalex.org/W2154802086","https://openalex.org/W2157867429","https://openalex.org/W2158349714","https://openalex.org/W2158896141","https://openalex.org/W2162674813","https://openalex.org/W2166475853","https://openalex.org/W2167435540","https://openalex.org/W2167482305","https://openalex.org/W2168438222","https://openalex.org/W2168909179","https://openalex.org/W2168921143","https://openalex.org/W2178006639","https://openalex.org/W2320114964","https://openalex.org/W2324560759","https://openalex.org/W2329820975","https://openalex.org/W2331424907","https://openalex.org/W2616798345","https://openalex.org/W2951462850"],"related_works":["https://openalex.org/W2789680039","https://openalex.org/W2971604533","https://openalex.org/W2161169616","https://openalex.org/W2907044704","https://openalex.org/W2885660394","https://openalex.org/W7045957346","https://openalex.org/W7043392196","https://openalex.org/W2150955135","https://openalex.org/W3094616909","https://openalex.org/W2119370961"],"abstract_inverted_index":{"Ever":[0],"since":[1],"unravelling":[2],"the":[3,22,27,82,92,101,133,158,184,213,225,230,238,242,251,271,277,287,290,306,312,316],"structure":[4],"of":[5,21,24,84,97,103,113,178,244,250,274,289,308,315],"DNA,":[6],"an":[7,246],"expanding":[8],"research":[9],"field":[10],"has":[11,34],"emerged":[12],"with":[13,73,263],"ongoing":[14],"efforts":[15],"dedicated":[16],"to":[17,40,46,79,91,132,165,171,211,220,303],"increase":[18],"our":[19],"understanding":[20],"molecule":[23],"life.":[25],"Since":[26],"natural":[28,85],"nucleobases":[29,77],"are":[30,125],"virtually":[31],"non-emissive,":[32],"it":[33,156,299],"been":[35],"a":[36,149,175,203,260,264],"challenge":[37],"for":[38,63,71],"decades":[39],"\u2018light":[41],"up\u2019":[42],"DNA/RNA":[43],"in":[44,152,209,224,285,295,310],"order":[45,170,307],"investigate":[47],"their":[48],"properties":[49,90,112],"utilizing":[50],"fluorescence":[51,89],"techniques.":[52],"This":[53],"thesis":[54],"focuses":[55],"on":[56,183,216,237],"fluorescent":[57,115,200],"nucleobase":[58],"analogues":[59,181],"(FBAs)":[60],"as":[61,148,202],"probes":[62],"fluorescently":[64],"labeling":[65],"DNA":[66,154,207,269],"and":[67,106,110,121,151,188,205,228],"investigating":[68],"its":[69,166],"interactions,":[70],"example,":[72],"proteins.":[74],"These":[75],"artificial":[76],"attempt":[78],"closely":[80],"mimic":[81,139],"characteristics":[83],"bases,":[86],"while":[87],"introducing":[88],"system.":[93],"The":[94,191,257],"first":[95],"part":[96,273],"this":[98,173,275],"work":[99],"comprises":[100],"characterization":[102],"both":[104,201],"new":[105,176],"established":[107,248],"FBAs.":[108],"Photophysical":[109],"base-mimicking":[111],"two":[114],"adenine":[116,119,123,138,180,195],"analogues,":[117],"triazole":[118,179],"(AT)":[120],"quadracyclic":[122],"(qA)":[124],"presented.":[126],"Both":[127],"exhibit":[128],"promising":[129,146],"features":[130],"compared":[131],"widely":[134],"used":[135],"commercially":[136],"available":[137],"2-aminopurine":[140],"(2-AP).":[141],"Even":[142],"though":[143],"AT":[144],"shows":[145],"emission":[147],"monomer":[150,204],"certain":[153],"surroundings,":[155],"destabilizes":[157,268],"B-DNA":[159],"duplex":[160],"structure,":[161],"most":[162],"likely":[163],"due":[164],"C8-triazole":[167],"extension.":[168],"In":[169],"overcome":[172],"effect,":[174],"family":[177],"extended":[182],"7-position":[185],"was":[186,255,283,300],"synthesized":[187],"photophysically":[189],"characterized.":[190],"second":[192,272],"thoroughly":[193],"characterized":[194],"analogue,":[196],"qA,":[197],"is":[198,218],"moderately":[199],"inside":[206],"but":[208],"contrast":[210],"AT,":[212],"two-ring":[214],"extension":[215],"qA":[217],"suggested":[219],"be":[221],"well":[222],"accommodated":[223],"major":[226],"groove":[227],"renders":[229],"DNA-duplex":[231],"unperturbed":[232],"or":[233],"even":[234],"stabilized,":[235],"depending":[236],"surrounding":[239],"sequence.":[240],"Finally,":[241],"photostability":[243],"tC,":[245],"already":[247],"FBA":[249,280],"tricyclic":[252,278],"cytosine":[253,279],"family,":[254],"investigated.":[256],"latter":[258],"yields":[259],"single":[261],"photoproduct":[262],"decreased":[265],"fluorescence,":[266],"which":[267,311],"duplexes.In":[270],"work,":[276],"FRET-pair,":[281],"tCO-tCnitro":[282],"applied":[284],"exploring":[286],"role":[288],"mammalian":[291],"transcription":[292,317],"factor":[293],"A":[294],"mitochondrial":[296],"transcription.":[297,320],"Furthermore,":[298],"called":[301],"upon":[302],"help":[304],"resolve":[305],"events":[309],"different":[313],"components":[314],"machinery":[318],"initiate":[319]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
