{"id":"https://openalex.org/W97069165","doi":null,"title":"Establishment of a concordant xenogeneic splenocyte injection model for the dynamic study of the marginal zone in the spleen.","display_name":"Establishment of a concordant xenogeneic splenocyte injection model for the dynamic study of the marginal zone in the spleen.","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W97069165","mag":"97069165","pmid":"https://pubmed.ncbi.nlm.nih.gov/9628563"},"language":"en","primary_location":{"id":"pmid:9628563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9628563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Yasutomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Yasutomi","raw_affiliation_strings":["Department of Surgery II, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079197186","display_name":"Mikako Ito","orcid":"https://orcid.org/0000-0002-1351-7602","observed_orcids":["https://orcid.org/0000-0002-1351-7602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021238675","display_name":"Shogo Hayashi","orcid":"https://orcid.org/0000-0003-0302-7658","observed_orcids":["https://orcid.org/0000-0003-0302-7658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Ohtsuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ohtsuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002736281","display_name":"Yasushi Namii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Namii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113754271","display_name":"Kozaburo Uchida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Uchida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047446260","display_name":"Itsuo Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Yokoyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091524095","display_name":"H Takagi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Takagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7401,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71013852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"452","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/splenic-marginal-zone","display_name":"splenic marginal zone","score":0.8529999852180481},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.949999988079071},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/immunoglobulin-m","display_name":"immunoglobulin M","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.9748214483261108},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7599702477455139},{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.7233707308769226},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.622613251209259},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5914056897163391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5844379663467407},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.46988561749458313},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4622464179992676},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44813308119773865},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4121943712234497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2485799789428711},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1082945168018341}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000910","descriptor_name":"Antibodies, Heterophile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014185","descriptor_name":"Transplantation, Isogeneic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9628563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9628563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation","raw_type":"Journal Article"},{"id":"mag:97069165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9628563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2420569808","https://openalex.org/W3030631526","https://openalex.org/W2415420174","https://openalex.org/W7101111137","https://openalex.org/W7017092976","https://openalex.org/W1492023113","https://openalex.org/W6996913884","https://openalex.org/W3083595944","https://openalex.org/W2067711614","https://openalex.org/W1569089695"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"was":[3,56,110,161],"undertaken":[4],"to":[5,32],"establish":[6],"a":[7,44,73,104,121,168,178],"simple":[8],"technique":[9],"with":[10,89,94,144,154,167,200],"which":[11],"we":[12],"could":[13],"investigate":[14],"the":[15,18,23,34,49,54,78,85,95,100,115,125,141,148,158,174,187,195,198,201,208,211,218],"relationship":[16],"between":[17],"marginal":[19],"zone":[20],"(MZ)":[21],"in":[22,40,71,84,137,177,186,197,224],"spleen":[24,199],"and":[25,64,77,91,128,153,181,215],"antispecies":[26],"antibody":[27,67,132,184],"production,":[28],"as":[29,31,163,165],"well":[30],"estimate":[33],"efficacy":[35,219],"of":[36,53,60,102,114,194,210,213,220],"various":[37,221],"immunosuppressive":[38,222],"treatments":[39,223],"xenotransplantation.":[41,226],"METHODS:":[42],"With":[43,120],"concordant":[45,108,122,169,225],"xenogeneic":[46,123,170],"combination":[47,157],"(hamster-to-rat),":[48],"early":[50],"phase":[51],"reaction":[52,214],"MZ":[55,86,126,149,159,175,196],"studied":[57],"by":[58,112],"use":[59,113],"quantitative":[61],"histologic":[62],"analysis,":[63],"complement-dependent":[65],"cytotoxic":[66],"titers":[68],"were":[69,87],"determined":[70],"both":[72,138],"heart":[74],"transplantation":[75],"model":[76,204],"splenocyte":[79,96,116,188,202],"injection":[80,97,117,189,203],"model.":[81,98,118,190],"Furthermore,":[82],"changes":[83],"examined":[88,111],"isogeneic":[90,146],"allogeneic":[92,156],"combinations":[93],"Next,":[99],"effect":[101],"cyclophosphamide,":[103],"promising":[105],"immunosuppressant":[106],"for":[107,207,216],"xenotransplantation,":[109],"RESULTS:":[119],"combination,":[124,147],"enlarged,":[127],"antihamster":[129],"immunoglobulin":[130],"M":[131],"synthesis":[133],"increased":[134],"after":[135],"immunization":[136],"models.":[139],"On":[140],"other":[142],"hand,":[143],"an":[145,155],"did":[150],"not":[151,162],"expand,":[152],"enlargement":[160],"great":[164],"that":[166],"combination.":[171],"Cyclophosphamide":[172],"suppressed":[173],"expansion":[176],"dose-dependent":[179],"manner":[180],"effectively":[182],"diminished":[183],"production":[185],"CONCLUSION:":[191],"Dynamic":[192],"studies":[193],"are":[205],"useful":[206],"elucidation":[209],"mechanisms":[212],"estimating":[217]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}