{"id":"https://openalex.org/W970209068","doi":null,"title":"Neurones and microglia in central nervous system immune response to degenerative processes. Part 1: Alzheimer's disease and Lewy body variant of Alzheimer's disease. Quantitative study.","display_name":"Neurones and microglia in central nervous system immune response to degenerative processes. Part 1: Alzheimer's disease and Lewy body variant of Alzheimer's disease. Quantitative study.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W970209068","mag":"970209068","pmid":"https://pubmed.ncbi.nlm.nih.gov/11770129"},"language":"en","primary_location":{"id":"pmid:11770129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11770129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060678024","display_name":"Grazyna Maria Szpak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"G M Szpak","raw_affiliation_strings":["Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa, Poland","institution_ids":["https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032571271","display_name":"Waldemar Lechowicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Lechowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033712942","display_name":"Eliza Lewandowska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Lewandowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114134892","display_name":"E Bertrand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Bertrand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033508332","display_name":"Teresa Wierzba\u2010Bobrowicz","orcid":"https://orcid.org/0000-0003-2518-8321","observed_orcids":["https://orcid.org/0000-0003-2518-8321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Wierzba-Bobrowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011307819","display_name":"Elzbieta Gwiazda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Gwiazda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017162636","display_name":"Bogna Schmidt-Sidor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Schmidt-Sidor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029899119","display_name":"Jerzy Dymecki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Dymecki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1937,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.50989819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":"3","first_page":"181","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.7459999918937683},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.7749999761581421},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cortical-association-areas","display_name":"cortical association areas","score":0.5989999771118164},{"id":"https://openalex.org/keywords/limbic-cortex","display_name":"limbic cortex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7362856268882751},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5497482419013977},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5408440828323364},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5246694087982178},{"id":"https://openalex.org/C541082541","wikidata":"https://www.wikidata.org/wiki/Q192560","display_name":"Limbic system","level":3,"score":0.44819676876068115},{"id":"https://openalex.org/C2993858690","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal cortex","level":2,"score":0.44421133399009705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43235641717910767},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4198744297027588},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3954066038131714},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32554590702056885},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28547853231430054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16656750440597534},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11455586552619934}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11770129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11770129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1011.6099","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1011.6099","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://old.viamedica.pl/gazety/gazetax3ang/darmowy_pdf.phtml?indeks%3D9%26indeks_art%3D44","raw_type":"text"},{"id":"mag:970209068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11770129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097065509","https://openalex.org/W4396704344","https://openalex.org/W2033354312","https://openalex.org/W1886711003","https://openalex.org/W2144489280","https://openalex.org/W2071852170","https://openalex.org/W4220740208","https://openalex.org/W2609965058","https://openalex.org/W3046932743","https://openalex.org/W2506280624"],"abstract_inverted_index":{"The":[0,123,259],"quantitative":[1],"correlation":[2,208],"between":[3,213],"neurone":[4,118,133,148,179,214,253],"loss":[5,134,149,177,215,254,281],"and":[6,21,26,32,50,68,87,106,128,136,181,195,216,239,284],"brain":[7,243],"immune":[8,237,242,277],"response,":[9],"assessed":[10],"by":[11,99],"intensity":[12,135,142],"of":[13,37,45,65,102,117,121,157,167,178,231,241,247,262,275,282,286],"microglia":[14,186,217],"inflammatory":[15,137,260],"reaction":[16,261],"in":[17,28,55,131,143,150,164,173,184,199,209,219,223,229,245,255,291],"cortical":[18,89],"association":[19,86,151],"area":[20],"limbic":[22,88,201],"cortex,":[23],"was":[24,188],"investigated":[25,85],"compared":[27],"previously":[29],"immunohistochemistry":[30],"(IHC)":[31],"ultrastructural":[33],"confirmed":[34,104],"11":[35],"cases":[36,42,73],"Alzheimer's":[38,146],"disease":[39],"(AD),":[40],"7":[41],"mixed":[43],"form":[44],"Dementia":[46],"with":[47,57,92,139,160,267],"AD":[48,66,105,127,224],"findings":[49],"Lewy":[51,62],"bodies":[52],"(AD/DLB)":[53],"reported,":[54],"accordance":[56],"Consortium":[58],"on":[59,234],"Dementia,":[60],"as":[61,110,112],"body":[63],"variant":[64],"(LBV)":[67,108],"6":[69],"non-demented":[70],"autopsy":[71],"control":[72,158,288],"from":[74],"63":[75],"to":[76,193,251,271,280],"86":[77],"years":[78],"old.":[79],"In":[80,145],"the":[81,165,176,182,200,210,232,235,256],"present":[82],"work":[83],"we":[84],"areas":[90],"linked":[91],"memory":[93],"mechanisms;":[94],"there":[95],"are":[96],"regions":[97],"characterised":[98],"early":[100],"distribution":[101],"IHC":[103],"DLB/AD":[107],"markers,":[109],"well":[111],"a":[113,273],"substantial":[114],"physiological":[115],"stability":[116],"pool":[119],"regardless":[120],"age.":[122],"results":[124],"indicated":[125],"that":[126],"LBV":[129],"differ":[130],"their":[132,287],"reaction,":[138],"much":[140],"higher":[141],"AD.":[144],"disease,":[147],"temporal":[152],"cortex":[153,202],"made":[154],"up":[155],"51%":[156],"values":[159],"simultaneous":[161],"8-fold":[162],"increase":[163,183],"density":[166,180],"MHC":[168,263],"II-positive":[169],"activated":[170,185],"microglia,":[171,265],"whereas":[172],"LBV,":[174],"both":[175,220],"density,":[187],"not":[189],"so":[190],"high":[191],"(up":[192],"41%":[194],"4-5-fold,":[196],"respectively).":[197],"Changes":[198],"were":[203],"less":[204],"pronounced.":[205],"A":[206],"strong":[207],"clinical":[211],"material":[212],"activation":[218],"processes,":[221],"especially":[222],"(r":[225],"=":[226],"0.73),":[227],"speaks":[228],"favour":[230],"hypothesis":[233],"neuronal":[236],"surveillance":[238],"arousal":[240],"response":[244,278],"conditions":[246],"declining":[248],"control,":[249],"due":[250,279],"significant":[252],"neurodegenerative":[257,268],"process.":[258],"II-immunoreactive":[264],"concomitant":[266],"process,":[269],"seems":[270],"be":[272],"consequence":[274],"increased":[276],"neurones":[283],"weakening":[285],"upon":[289],"immunosurveillance":[290],"central":[292],"nervous":[293],"system.":[294]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
