{"id":"https://openalex.org/W96999970","doi":"https://doi.org/10.1007/978-94-007-7606-7_4","title":"Estimation and Validation of Markov Models","display_name":"Estimation and Validation of Markov Models","publication_year":2013,"publication_date":"2013-12-02","ids":{"openalex":"https://openalex.org/W96999970","doi":"https://doi.org/10.1007/978-94-007-7606-7_4","mag":"96999970","pmid":"https://pubmed.ncbi.nlm.nih.gov/24297274"},"language":"en","primary_location":{"id":"doi:10.1007/978-94-007-7606-7_4","doi":"https://doi.org/10.1007/978-94-007-7606-7_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-007-7606-7_4","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W585413800","display_name":"An Introduction to Markov State Models and Their Application to Long Timescale Molecular Simulation"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038990214","display_name":"Jan-Hendrik Prinz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan-Hendrik Prinz","raw_affiliation_strings":["Freie Universit\u00e4t Berlin, Arnimallee 6, 14195, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Freie Universit\u00e4t Berlin, Arnimallee 6, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083925073","display_name":"John D. Chodera","orcid":"https://orcid.org/0000-0003-0542-119X","observed_orcids":["https://orcid.org/0000-0003-0542-119X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Chodera","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055016850","display_name":"Frank No\u00e9","orcid":"https://orcid.org/0000-0003-4169-9324","observed_orcids":["https://orcid.org/0000-0003-4169-9324"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank No\u00e9","raw_affiliation_strings":["Freie Universit\u00e4t Berlin, Arnimallee 6, 14195, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Freie Universit\u00e4t Berlin, Arnimallee 6, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055016850"],"corresponding_institution_ids":["https://openalex.org/I75951250"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0308642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"797","issue":null,"first_page":"45","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12044","display_name":"Advanced Physical and Chemical Molecular Interactions","score":0.35249999165534973,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12044","display_name":"Advanced Physical and Chemical Molecular Interactions","score":0.35249999165534973,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12056","display_name":"Markov Chains and Monte Carlo Methods","score":0.31349998712539673,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transition-matrix-estimation","display_name":"transition matrix estimation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/discrete-state-space","display_name":"discrete state space","score":0.8059999942779541},{"id":"https://openalex.org/keywords/molecular-kinetics","display_name":"molecular kinetics","score":0.824999988079071},{"id":"https://openalex.org/keywords/simulated-data","display_name":"simulated data","score":0.593999981880188},{"id":"https://openalex.org/keywords/kinetic-modeling","display_name":"kinetic modeling","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.7575629949569702},{"id":"https://openalex.org/C163836022","wikidata":"https://www.wikidata.org/wiki/Q6771326","display_name":"Markov model","level":3,"score":0.6706165075302124},{"id":"https://openalex.org/C2779089604","wikidata":"https://www.wikidata.org/wiki/Q7169333","display_name":"Permission","level":2,"score":0.555841863155365},{"id":"https://openalex.org/C72434380","wikidata":"https://www.wikidata.org/wiki/Q230930","display_name":"State space","level":2,"score":0.5170648694038391},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5088182091712952},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.5005316734313965},{"id":"https://openalex.org/C54907487","wikidata":"https://www.wikidata.org/wiki/Q7915688","display_name":"Variable-order Markov model","level":4,"score":0.4850243926048279},{"id":"https://openalex.org/C159886148","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov process","level":2,"score":0.43187737464904785},{"id":"https://openalex.org/C189973286","wikidata":"https://www.wikidata.org/wiki/Q176695","display_name":"Markov property","level":4,"score":0.4148312509059906},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3370353877544403},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.29510632157325745},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2398781180381775},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.174958735704422},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16527315974235535},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-94-007-7606-7_4","doi":"https://doi.org/10.1007/978-94-007-7606-7_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-007-7606-7_4","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:24297274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24297274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1830165584","https://openalex.org/W1979070806","https://openalex.org/W1985277612","https://openalex.org/W1988220126","https://openalex.org/W1991901383","https://openalex.org/W2010005232","https://openalex.org/W2016885268","https://openalex.org/W2021541427","https://openalex.org/W2025899185","https://openalex.org/W2027593773","https://openalex.org/W2029564559","https://openalex.org/W2040809566","https://openalex.org/W2044201287","https://openalex.org/W2053348581","https://openalex.org/W2056859449","https://openalex.org/W2056975402","https://openalex.org/W2059187210","https://openalex.org/W2062421175","https://openalex.org/W2064996945","https://openalex.org/W2075243501","https://openalex.org/W2085213650","https://openalex.org/W2088647884","https://openalex.org/W2091707670","https://openalex.org/W2099131014","https://openalex.org/W2111339528","https://openalex.org/W2149655632","https://openalex.org/W2208376505","https://openalex.org/W3124419597"],"related_works":["https://openalex.org/W1985664346","https://openalex.org/W2118728396","https://openalex.org/W1976065452","https://openalex.org/W2130519334","https://openalex.org/W4360597163","https://openalex.org/W3023188449","https://openalex.org/W3164302780","https://openalex.org/W1974839821","https://openalex.org/W3113307220","https://openalex.org/W4240129243"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}