{"id":"https://openalex.org/W96975378","doi":null,"title":"Determinants of villous trophoblastic hyperplasia in spontaneous abortions.","display_name":"Determinants of villous trophoblastic hyperplasia in spontaneous abortions.","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W96975378","mag":"96975378","pmid":"https://pubmed.ncbi.nlm.nih.gov/9720505"},"language":"en","primary_location":{"id":"pmid:9720505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9720505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033583830","display_name":"Raymond W. Redline","orcid":"https://orcid.org/0000-0002-8038-0626","observed_orcids":["https://orcid.org/0000-0002-8038-0626"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Redline","raw_affiliation_strings":["Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA. rwr53@aol.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA. rwr53@aol.com","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059274954","display_name":"T. Hassold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hassold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084802577","display_name":"Michael V. Zaragoza","orcid":"https://orcid.org/0000-0002-3459-9002","observed_orcids":["https://orcid.org/0000-0002-3459-9002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Zaragoza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7852,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.83897916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"8","first_page":"762","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hydatidiform-mole","display_name":"hydatidiform mole","score":0.6539999842643738},{"id":"https://openalex.org/keywords/complete-hydatidiform-mole","display_name":"complete hydatidiform mole","score":0.4569999873638153},{"id":"https://openalex.org/keywords/partial-mole","display_name":"partial mole","score":0.9449999928474426},{"id":"https://openalex.org/keywords/trisomy","display_name":"trisomy","score":0.847000002861023},{"id":"https://openalex.org/keywords/triploidy","display_name":"triploidy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tetraploidy","display_name":"tetraploidy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/monosomy-x","display_name":"monosomy X","score":0.9570000171661377},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.6729999780654907},{"id":"https://openalex.org/keywords/fetal-tissue","display_name":"fetal tissue","score":0.5979999899864197},{"id":"https://openalex.org/keywords/chromosome-7-trisomy","display_name":"chromosome 7 trisomy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.7207987308502197},{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.5801383256912231},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.5416581630706787},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.5333260297775269},{"id":"https://openalex.org/C2779142324","wikidata":"https://www.wikidata.org/wiki/Q3321288","display_name":"Monosomy","level":5,"score":0.4900180399417877},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4868992865085602},{"id":"https://openalex.org/C2777689261","wikidata":"https://www.wikidata.org/wiki/Q686574","display_name":"Endometrial hyperplasia","level":3,"score":0.4778853952884674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4557095170021057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44948631525039673},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3339686989784241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33297455310821533},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.23218873143196106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09302201867103577},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002824","descriptor_name":"Chorionic Villi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002824","descriptor_name":"Chorionic Villi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002824","descriptor_name":"Chorionic Villi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006828","descriptor_name":"Hydatidiform Mole","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006828","descriptor_name":"Hydatidiform Mole","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006828","descriptor_name":"Hydatidiform Mole","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006828","descriptor_name":"Hydatidiform Mole","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006828","descriptor_name":"Hydatidiform Mole","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006828","descriptor_name":"Hydatidiform Mole","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012730","descriptor_name":"Sex Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012730","descriptor_name":"Sex Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012730","descriptor_name":"Sex Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014314","descriptor_name":"Trisomy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014314","descriptor_name":"Trisomy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014314","descriptor_name":"Trisomy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9720505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9720505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},{"id":"mag:96975378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9720505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"display_name":"Gender equality","id":"https://metadata.un.org/sdg/5"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8403051998","display_name":"A PROGRAM OF RESEARCH IN POPULATION CYTOGENETICS","funder_award_id":"R01HD021341","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006507147","https://openalex.org/W1995661335","https://openalex.org/W2403369485","https://openalex.org/W2144623119","https://openalex.org/W2422439586","https://openalex.org/W2418001952","https://openalex.org/W1968659359","https://openalex.org/W1972477564","https://openalex.org/W2362445015","https://openalex.org/W2066376709"],"abstract_inverted_index":{"The":[0],"diagnosis":[1],"of":[2,11,50,72,96,132,161,170,193,236],"complete":[3,51,153],"and":[4,60,106,123,137,152,185,209,226,255,275],"partial":[5,151],"mole":[6],"with":[7,117,127,130,168,208,221,271],"its":[8],"subsequent":[9],"risk":[10],"trophoblastic":[12,38,110],"malignancy":[13],"relies":[14],"on":[15,29],"histologic":[16],"criteria":[17],"that":[18,147,247,258],"are":[19],"sometimes":[20],"seen":[21,148],"in":[22,46,82,114,124,144,149,158,200,206,217,223,233,245,256],"nonmolar":[23],"conceptuses.":[24,228],"We":[25,86],"performed":[26],"karyotypic":[27],"analysis":[28],"1054":[30],"spontaneous":[31,115],"abortions":[32,116,235],"during":[33],"a":[34,121,133,159,214],"43-month":[35],"period.":[36],"Villous":[37,109],"hyperplasia":[39,111,140,211,222],"was":[40,76,112,155,204,213,230,268],"graded":[41],"from":[42],"0":[43],"to":[44,146],"3":[45],"successfully":[47],"karyotyped":[48],"cases":[49,207],"mole,":[52],"triploidy,":[53],"tetraploidy,":[54],"monosomy":[55],"X,":[56],"trisomy,":[57],"normal":[58,61,134,227],"46,XY,":[59],"46,XX":[62],"without":[63,210],"contaminating":[64],"maternal":[65],"tissues":[66],"(n":[67],"=":[68,243,263],"649).":[69],"Parental":[70],"origin":[71,195],"the":[73,92,125,197],"extra":[74,198],"chromosome":[75,199],"analyzed":[77],"by":[78],"polymerase":[79],"chain":[80],"reaction":[81],"64":[83],"trisomic":[84,225,234],"cases.":[85],"also":[87],"evaluated":[88],"for":[89,196],"each":[90],"case":[91],"developmental":[93],"stage,":[94],"presence":[95],"uniformly":[97,249],"hydropic":[98,250],"villi,":[99],"amnion,":[100],"villous":[101],"nucleated":[102],"red":[103],"blood":[104],"cells,":[105],"fetal":[107,260],"tissue.":[108],"increased":[113],"abnormal":[118],"karyotype":[119],"as":[120],"group":[122],"subgroup":[126,160],"trisomy":[128],"compared":[129],"those":[131,246,257],"karyotype.":[135],"Hyperplasia":[136,229],"particularly":[138,269],"high-grade":[139],"(Grades":[141],"2-3),":[142],"equivalent":[143],"severity":[145],"proliferative":[150],"moles":[154],"most":[156],"frequent":[157],"trisomies":[162,203,272],"involving":[163],"chromosomes":[164,220],"7":[165],"(60%":[166],"hyperplasia,":[167,175,181,188],"30%":[169],"high":[171,177,183,190],"grade),":[172,178,184],"15":[173],"(50%":[174],"15%":[176],"21":[179],"(22%":[180],"11%":[182],"22":[186],"(13%":[187],"4%":[189],"grade).":[191],"Frequency":[192],"paternal":[194],"these":[201],"four":[202],"similar":[205],"There":[212],"nonsignificant":[215],"increase":[216],"female":[218],"sex":[219],"both":[224],"more":[231],"common":[232,270],"late":[237],"stage":[238],"(>":[239],"8.5":[240],"wk,":[241],"P":[242],".013),":[244],"lacked":[248,259],"villi":[251],"(P":[252,262],"<":[253],".001),":[254],"tissue":[261],".204).":[264],"This":[265],"latter":[266],"phenotype":[267],"15,":[273],"21,":[274],"22.":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
