{"id":"https://openalex.org/W96946459","doi":null,"title":"Effects of halothane, enflurane and isoflurane on some energy-converting functions of isolated rat liver mitochondria.","display_name":"Effects of halothane, enflurane and isoflurane on some energy-converting functions of isolated rat liver mitochondria.","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W96946459","mag":"96946459","pmid":"https://pubmed.ncbi.nlm.nih.gov/2624300"},"language":"en","primary_location":{"id":"pmid:2624300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2624300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020784832","display_name":"Ezio Vincenti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Vincenti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058573872","display_name":"Donata Branca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Branca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088499988","display_name":"M Varotto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Varotto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063261026","display_name":"Guido Scutari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Scutari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.00395149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"30","issue":"9-10","first_page":"517","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.9909999966621399},{"id":"https://openalex.org/keywords/enflurane","display_name":"enflurane","score":1.0},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.9980000257492065},{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.9290000200271606},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.8199999928474426},{"id":"https://openalex.org/keywords/calcium-uptake","display_name":"calcium uptake","score":0.8090000152587891},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.7820000052452087},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2777858289","wikidata":"https://www.wikidata.org/wiki/Q416740","display_name":"Enflurane","level":3,"score":0.9905450344085693},{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.9516171216964722},{"id":"https://openalex.org/C2776932660","wikidata":"https://www.wikidata.org/wiki/Q32921","display_name":"Halothane","level":2,"score":0.9486138820648193},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.8357456922531128},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.642916202545166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5980038642883301},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.50730961561203},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4833242893218994},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40350696444511414},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38393789529800415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3804381489753723},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36428362131118774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21067798137664795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13442373275756836},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09894689917564392}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004737","descriptor_name":"Enflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2624300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2624300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression","raw_type":"Journal Article"},{"id":"pmh:oai:www.research.unipd.it:11577/2508175","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2508175","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:96946459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2624300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2411164329","https://openalex.org/W1969798135","https://openalex.org/W2387217801","https://openalex.org/W7095571872","https://openalex.org/W1987266039","https://openalex.org/W3110874610","https://openalex.org/W1977264231","https://openalex.org/W2076201030","https://openalex.org/W2031933537","https://openalex.org/W2070663098"],"abstract_inverted_index":{"Enflurane":[0],"and":[1,31,76,127,137],"isoflurane":[2,32,75,101,128],"appeared":[3],"equally":[4],"effective":[5,21],"in":[6,13,64],"decreasing":[7],"the":[8,27,38,49,72,79,97,105,122,134,138,144],"efficiency":[9],"of":[10,40,74,100,111,124],"oxidative":[11],"phosphorylation":[12],"isolated":[14,130],"mitochondria,":[15],"while":[16,109],"halothane":[17],"was":[18,42,53],"twice":[19],"as":[20,22,104],"these":[23],"two":[24],"anesthetics.":[25],"On":[26],"other":[28],"hand":[29],"enflurane":[30,77,112,126],"exhibited":[33],"different":[34,153],"dose-response":[35],"relationships":[36],"when":[37],"uptake":[39,63],"calcium":[41,62],"measured":[43],"(with":[44,55],"a":[45,116],"calcium-selective":[46],"electrode)":[47,57],"or":[48,61],"transmembrane":[50],"electrical":[51],"potential":[52],"monitored":[54],"tetraphenylphosphonium-selective":[56],"during":[58],"ATP":[59,135],"synthesis":[60],"anesthetic":[65,106],"treated":[66],"mitochondria.":[67],"The":[68],"results":[69],"indicate":[70],"that":[71,110,121],"effects":[73,123,150],"on":[78,129],"mitochondrial":[80],"energy":[81],"converting":[82],"processes":[83],"are":[84,151],"qualitatively,":[85],"but":[86],"not":[87],"quantitatively,":[88],"analogous":[89],"to":[90],"those":[91],"previously":[92],"described":[93],"for":[94,148,154],"halothane.":[95],"Moreover":[96],"damaging":[98],"action":[99],"gradually":[102],"increases":[103,114],"concentration":[107],"increases,":[108],"suddenly":[113],"above":[115],"threshold":[117],"concentration.":[118],"It":[119],"appears":[120],"halothane,":[125],"mitochondria":[131],"involve":[132],"both":[133],"synthetase":[136],"inner":[139],"membrane":[140],"permeability":[141],"barrier,":[142],"although":[143],"membrane-anesthetic":[145],"interactions":[146],"responsible":[147],"such":[149],"probably":[152],"each":[155],"anesthetic.":[156]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
