{"id":"https://openalex.org/W96904577","doi":null,"title":"Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.","display_name":"Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W96904577","mag":"96904577","pmid":"https://pubmed.ncbi.nlm.nih.gov/19966940","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2776283"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2776283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2776283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2776283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070743195","display_name":"Elona Rrapo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elona Rrapo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078085024","display_name":"Yuyan Zhu","orcid":"https://orcid.org/0000-0003-0479-3151","observed_orcids":["https://orcid.org/0000-0003-0479-3151","https://orcid.org/0000-0002-6869-0226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuyan Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019315614","display_name":"Jun Tian","orcid":"https://orcid.org/0000-0002-3053-5001","observed_orcids":["https://orcid.org/0000-0002-3053-5001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110188393","display_name":"Huayan Hou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huayan Hou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Adam Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Francisco Fernandez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco Fernandez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080768607","display_name":"Jun Tan","orcid":"https://orcid.org/0000-0002-1703-8596","observed_orcids":["https://orcid.org/0000-0002-1703-8596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007053933","display_name":"Brian N. Giunta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Giunta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6487,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.82647228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"72","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.09359999746084213,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/green-tea","display_name":"green tea","score":0.7919999957084656},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hiv-associated-dementia","display_name":"HIV-associated dementia","score":0.7580000162124634},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.9269999861717224},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6859999895095825},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.9795116186141968},{"id":"https://openalex.org/C2908656565","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrocytosis","level":3,"score":0.9281578063964844},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6588285565376282},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5503541231155396},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.542154848575592},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5263864994049072},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.5239869952201843},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5147895812988281},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5028612017631531},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.46703028678894043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.395940899848938},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3905845880508423},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36763226985931396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3618030548095703},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.337383896112442},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32530492544174194},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2982044816017151},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23000121116638184},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15642061829566956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12505972385406494},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2776283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2776283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:19966940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19966940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:96904577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19966940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2776283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2776283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7453664923","display_name":"The Role of HIV-1 Tat in Alzheimer's Disease","funder_award_id":"K08MH082642","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W10199311","https://openalex.org/W281134522","https://openalex.org/W1524845305","https://openalex.org/W1531305298","https://openalex.org/W1585492421","https://openalex.org/W1608569484","https://openalex.org/W1964746292","https://openalex.org/W1974702421","https://openalex.org/W1979491836","https://openalex.org/W1983166842","https://openalex.org/W1983740174","https://openalex.org/W1988867016","https://openalex.org/W1995746794","https://openalex.org/W1999613356","https://openalex.org/W2000807470","https://openalex.org/W2003186832","https://openalex.org/W2014439767","https://openalex.org/W2019425955","https://openalex.org/W2045301606","https://openalex.org/W2046204149","https://openalex.org/W2062200627","https://openalex.org/W2089883535","https://openalex.org/W2106822021","https://openalex.org/W2117045986","https://openalex.org/W2119395157","https://openalex.org/W2138902434","https://openalex.org/W2146384070","https://openalex.org/W2146901670","https://openalex.org/W2147638621","https://openalex.org/W2150886578","https://openalex.org/W2158096469"],"related_works":["https://openalex.org/W88782153","https://openalex.org/W2019425955","https://openalex.org/W1578794980","https://openalex.org/W2168144334","https://openalex.org/W2793868498","https://openalex.org/W4319296201","https://openalex.org/W1964746292","https://openalex.org/W2012911450","https://openalex.org/W4400033427","https://openalex.org/W2327359632"],"abstract_inverted_index":{"In":[0],"the":[1,7,14,30,50],"current":[2],"era":[3],"of":[4,9,52,147],"antiretroviral":[5],"treatment,":[6],"prevalence":[8],"HIV-associated":[10],"dementia":[11],"is":[12],"on":[13],"rise.":[15],"Many":[16],"past":[17],"works":[18],"have":[19],"associated":[20,150],"inflammation":[21],"and":[22,67,115,128,149,152],"neuronal":[23,68,119,153],"loss":[24,69,120],"with":[25],"cognitive":[26],"deficits":[27],"inherent":[28],"to":[29,39,63,138],"syndrome.":[31],"Importantly,":[32],"HIV-1":[33,72],"induced":[34],"astrogliosis":[35,96],"has":[36],"been":[37],"shown":[38],"play":[40],"a":[41,82,106],"central":[42],"role":[43],"in":[44,70,109,118,143],"this":[45],"process.":[46],"Here":[47],"we":[48,89],"examined":[49],"effect":[51],"green":[53],"tea":[54],"derived":[55],"(-)-epigallocatechin-3-gallate":[56],"(EGCG)":[57],"food":[58],"supplementation":[59],"for":[60],"its":[61],"ability":[62],"modulate":[64],"GFAP":[65,100,148],"expression":[66,78],"an":[71],"Tat":[73],"transgenic":[74],"mouse":[75],"model":[76],"whose":[77],"was":[79,103],"controlled":[80],"by":[81,99,105,112,125],"brain":[83],"specific":[84],"doxycycline":[85],"promoter.":[86],"By":[87],"immunohistochemistry":[88],"found":[90],"that":[91],"EGCG":[92,144],"(300mg/kg/day)":[93],"dramatically":[94],"reduced":[95],"as":[97,123],"demonstrated":[98,124],"expression.":[101],"This":[102],"accompanied":[104],"mild":[107],"reduction":[108,117],"activated":[110],"microglia":[111],"Iba-1":[113],"staining":[114,127],"significant":[116],"through":[121],"apoptosis":[122],"MAP2":[126],"Western":[129],"blot":[130],"analysis":[131],"respectively.":[132],"Future":[133],"studies":[134],"will":[135],"be":[136],"required":[137],"determine":[139],"intracellular":[140],"mechanism":[141],"involved":[142],"mediated":[145],"downregulation":[146],"astrocytosis":[151],"loss.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}