{"id":"https://openalex.org/W968404039","doi":null,"title":"\u7626\u7d20\uff08leptin\uff09\u8bf1\u5bfc\u65b0\u751f\u5927\u9f20\u5fc3\u5ba4\u808c\u7ec6\u80de\u7684\u80a5\u539a","display_name":"\u7626\u7d20\uff08leptin\uff09\u8bf1\u5bfc\u65b0\u751f\u5927\u9f20\u5fc3\u5ba4\u808c\u7ec6\u80de\u7684\u80a5\u539a","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W968404039","mag":"968404039"},"language":"zh","primary_location":{"id":"mag:968404039","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/88327X/200305/23347407.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541503","display_name":"\u4e2d\u56fd\u5206\u5b50\u5fc3\u810f\u75c5\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u5206\u5b50\u5fc3\u810f\u75c5\u5b66\u6742\u5fd7","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045839676","display_name":"\u5f20\u9707","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f20\u9707","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102215365","display_name":"Rutai Hui","orcid":"https://orcid.org/0000-0001-7393-2544","observed_orcids":["https://orcid.org/0000-0001-7393-2544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u60e0\u6c5d\u592a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09764493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"5","first_page":"312","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neonatal-rat-ventricular-myocytes","display_name":"neonatal rat ventricular myocytes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cell-surface-area","display_name":"cell surface area","score":0.6079999804496765},{"id":"https://openalex.org/keywords/skeletal-alpha-actin","display_name":"alpha-skeletal actin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/myosin-light-chain-2","display_name":"myosin light chain 2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9850000143051147},{"id":"https://openalex.org/keywords/p44-42-mapk","display_name":"p44/42 MAPK","score":0.8960000276565552},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.38053658604621887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2546161115169525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1907401978969574},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.09376335144042969}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:968404039","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/88327X/200305/23347407.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541503","display_name":"\u4e2d\u56fd\u5206\u5b50\u5fc3\u810f\u75c5\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u5206\u5b50\u5fc3\u810f\u75c5\u5b66\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116649734","https://openalex.org/W7098512409","https://openalex.org/W2089978350","https://openalex.org/W2033389820","https://openalex.org/W2004341742","https://openalex.org/W2115719865","https://openalex.org/W2165799170","https://openalex.org/W89918477","https://openalex.org/W2145334695","https://openalex.org/W19531876"],"abstract_inverted_index":{"\u80a5\u80d6\u7684\u4e00\u4e2a\u4e3b\u8981\u8868\u73b0\u662f\u6765\u6e90\u4e8e\u8102\u80aa\u7ec6\u80de\u7684\u5927\u5c0f\u4e3a16kDa\u7684leptin\u589e\u52a0,leptin\u5728\u5fc3\u810f\u75be\u75c5\u5982\u5145\u8840\u6027\u5fc3\u8870\u4e2d\u4e5f\u4f1a\u589e\u52a0.\u7136\u800c,leptin\u80fd\u5426\u76f4\u63a5\u6539\u53d8\u5fc3\u810f\u8868\u578b\u8fd8\u672a\u660e\u786e.\u56e0\u6b64,\u6211\u4eec\u5229\u75281\uff5e4d\u7684\u65b0\u751f\u5927\u9f20\u5fc3\u5ba4\u808c\u7ec6\u80de\u6765\u7814\u7a76leptin\u4f5c\u4e3a\u6f5c\u5728\u7684\u80a5\u539a\u56e0\u5b50\u7684\u4f5c\u7528.\u5229\u7528RT-PCR,\u6211\u4eec\u53d1\u73b0\u8fd9\u4e9b\u7ec6\u80de\u53ef\u4ee5\u8868\u8fbe\u77ed\u578b(OB-Ra)leptin\u53d7\u4f53.\u7528leptin(0.31\uff5e31.3nmol/L)\u5904\u7406\u7ec6\u80de24h\u540e,\u53d1\u73b0\u7ec6\u80de\u8868\u9762\u79ef\u660e\u663e\u589e\u5927,\u8fbe\u5230\u6700\u5927\u8868\u9762\u79ef\u65f6\u7684leptin\u6d53\u5ea6\u4e3a0.63nmol/L.\u968f\u540e\u7684\u5b9e\u9a8c\u4f7f\u75283.1nmol/L\u7684leptin\u5904\u7406\u7ec6\u80de,\u53d1\u73b0\u7ec6\u80de\u8868\u9762\u79ef\u589e\u52a042%,\u86cb\u767d\u5408\u6210\u589e\u52a032%,\u03b1-\u9aa8\u9abc\u808c\u808c\u52a8\u86cb\u767d\u548c\u808c\u7403\u86cb\u767d\u8f7b\u94fe-2\u8868\u8fbe\u5206\u522b\u589e\u52a0250%\u548c300%.\u8fd9\u4e9b\u4e8b\u4ef6\u53d1\u751f\u5e76\u4e0d\u4f34\u968f\u7740\u7ec6\u80de\u6b7b\u4ea1\u7684\u589e\u52a0.\u5305\u62ecp38\u548cp44/42\u5728\u5185\u7684\u4e1d\u88c2\u539f\u6fc0\u6d3b\u86cb\u767d\u6fc0\u9176\u7cfb\u7edf(MAPK)\u7684\u5feb\u901f\u6fc0\u6d3b\u53d1\u751f\u5728\u80a5\u539a\u53cd\u5e94\u4e4b\u524d,\u5728leptin\u5904\u7406\u540e\u76845min\u5c31\u88ab\u6fc0\u6d3b.\u7528p38\u7684\u6291\u5236\u5242SB203580\u80fd\u591f\u6291\u5236leptin\u5f15\u8d77\u7684\u80a5\u539a,\u4f46\u662f\u7528p44/42\u7684\u6291\u5236\u5242PD98059\u5374\u4e0d\u80fd\u6291\u5236\u8fd9\u79cd\u80a5\u539a.\u6211\u4eec\u7684\u5b9e\u9a8c\u7ed3\u679c\u8bc1\u660e,leptin\u662f\u4e00\u4e2a\u76f4\u63a5\u7684\u80a5\u539a\u56e0\u7d20,\u53ef\u80fd\u5728\u80a5\u539a\u548c\u9ad8\u6d53\u5ea6\u7684leptin\u73af\u5883\u5982\u80a5\u80d6\u4e4b\u95f4\u63d0\u4f9b\u4e86\u4e00\u4e2a\u751f\u7269\u5b66\u4e0a\u7684\u5173\u8054.":[0]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}