{"id":"https://openalex.org/W968137913","doi":"https://doi.org/10.1096/fasebj.20.5.a979","title":"L\u2010Arginine Alleviates Hyperglycemia\u2010Induced Vascular Inflammation In Diabetic Mice","display_name":"L\u2010Arginine Alleviates Hyperglycemia\u2010Induced Vascular Inflammation In Diabetic Mice","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W968137913","doi":"https://doi.org/10.1096/fasebj.20.5.a979","mag":"968137913"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.20.5.a979","doi":"https://doi.org/10.1096/fasebj.20.5.a979","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.5.a979","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086141649","display_name":"Matthew West","orcid":"https://orcid.org/0000-0003-3247-1774","observed_orcids":["https://orcid.org/0000-0003-3247-1774"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew B West","raw_affiliation_strings":["Institute of Molecular Cardiology and Biochemistry and Molecular Biology University of Louisville Delia Baxter Bldg. Rm 421, 580 S Preston St. Louisville KY 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Cardiology and Biochemistry and Molecular Biology University of Louisville Delia Baxter Bldg. Rm 421, 580 S Preston St. Louisville KY 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064352695","display_name":"Kota V. Ramana","orcid":"https://orcid.org/0000-0001-6502-7800","observed_orcids":["https://orcid.org/0000-0001-6502-7800"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kota V. Ramana","raw_affiliation_strings":["Department of Human Biological Chemistry and Genetics University of Texas Medical Branch 6.644 Basic Science Bldg., 301 Univesity Blvd. Galveston TX 77555\u20105302"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biological Chemistry and Genetics University of Texas Medical Branch 6.644 Basic Science Bldg., 301 Univesity Blvd. Galveston TX 77555\u20105302","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054743695","display_name":"Srivastava Sk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satish K Srivastava","raw_affiliation_strings":["Department of Human Biological Chemistry and Genetics University of Texas Medical Branch 6.644 Basic Science Bldg., 301 Univesity Blvd. Galveston TX 77555\u20105302"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biological Chemistry and Genetics University of Texas Medical Branch 6.644 Basic Science Bldg., 301 Univesity Blvd. Galveston TX 77555\u20105302","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012248310","display_name":"Aruni Bhatnagar","orcid":"https://orcid.org/0000-0001-6818-0384","observed_orcids":["https://orcid.org/0000-0001-6818-0384"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aruni Bhatnagar","raw_affiliation_strings":["Institute of Molecular Cardiology and Biochemistry and Molecular Biology University of Louisville Delia Baxter Bldg. Rm 421, 580 S Preston St. Louisville KY 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Cardiology and Biochemistry and Molecular Biology University of Louisville Delia Baxter Bldg. Rm 421, 580 S Preston St. Louisville KY 40202","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09517541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":1.0},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.890999972820282},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9229999780654907},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.7480000257492065},{"id":"https://openalex.org/keywords/soluble-icam-1","display_name":"soluble ICAM-1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/aldose-reductase","display_name":"aldose reductase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/polyol-pathway","display_name":"polyol pathway","score":0.9369999766349792},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7900000214576721},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.800000011920929},{"id":"https://openalex.org/keywords/diabetic-cardiovascular-complications","display_name":"cardiovascular complications of diabetes","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C136502266","wikidata":"https://www.wikidata.org/wiki/Q7226667","display_name":"Polyol pathway","level":4,"score":0.8553323745727539},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.7796074151992798},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7642499208450317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.726952314376831},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7045664191246033},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.6928530931472778},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6816956996917725},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5866495966911316},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5259642601013184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49552643299102783},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4800490140914917},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4244905114173889},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38779741525650024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12121647596359253},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.20.5.a979","doi":"https://doi.org/10.1096/fasebj.20.5.a979","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.5.a979","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089472722","https://openalex.org/W1972891217","https://openalex.org/W4223589519","https://openalex.org/W3176366587","https://openalex.org/W2136055847","https://openalex.org/W250149064","https://openalex.org/W2257227626","https://openalex.org/W2158898468","https://openalex.org/W1998426676","https://openalex.org/W4412988242"],"abstract_inverted_index":{"Cardiovascular":[0],"complications":[1],"of":[2,44,58,84,110,129,137,174],"diabetes":[3],"are":[4],"associated":[5],"with":[6,25,39,46,87,170],"a":[7],"decrease":[8],"in":[9,72,81,101,124],"nitric":[10],"oxide":[11],"(NO)":[12],"bioavailability.":[13],"In":[14],"this":[15],"study,":[16],"we":[17],"tested":[18],"the":[19,82,107,135,175],"hypothesis":[20],"that":[21,168],"enhancing":[22],"NO":[23,53],"production":[24],"L\u2010arginine":[26],"(Arg)":[27],"would":[28],"mitigate":[29],"diabetic":[30,59,74,85,102],"vascular":[31,180],"stress.":[32],"Diabetes":[33,104],"was":[34,141],"induced":[35],"by":[36,92,116,163],"injecting":[37],"mice":[38,60,89],"streptozotocin":[40],"(STZ).":[41],"Two":[42],"weeks":[43],"treatment":[45,57,97,155,169],"Arg":[47,56,96,117,119,154,171],"using":[48,150],"osmotic":[49],"pumps":[50],"increased":[51,77,106,156],"plasma":[52,108],"x":[54],"levels.":[55],"decreased":[61,98,115],"triglycerides":[62],"from":[63,143],"59.1":[64],"\u00b1":[65,69],"18.1":[66],"to":[67],"116.1":[68],"18.0":[70],"mg/dl":[71],"saline\u2010treated":[73],"mice.":[75,103],"Hyperglycemia":[76],"superoxide":[78],"generation":[79],"6\u2010fold":[80],"aorta":[83],"compared":[86],"non\u2010diabetic":[88],"as":[90],"measured":[91],"dihydroethidium":[93],"(DHE)":[94],"staining.":[95],"DHE":[99],"staining":[100],"also":[105],"levels":[109],"soluble":[111],"ICAM":[112],"which":[113],"were":[114,148],"treatment.":[118],"supplementation":[120],"abolished":[121],"diabetes\u2010induced":[122],"increases":[123],"renal":[125],"sorbitol,":[126],"indicating":[127,159],"inhibition":[128,162],"aldose":[130],"reductase":[131],"(AR).":[132],"To":[133],"determine":[134],"mechanism":[136],"AR":[138,140,157,161],"inhibition,":[139],"immunoprecipitated":[142],"heart":[144],"and":[145,178,183],"Western":[146],"blots":[147],"developed":[149],"anti\u2010protein":[151],"glutathione":[152],"antibodies.":[153],"glutathiolation;":[158],"NO\u2010induced":[160],"glutathiolation.":[164],"These":[165],"observations":[166],"demonstrate":[167],"prevents":[172],"activation":[173],"polyol":[176],"pathway":[177],"decreases":[179],"oxidative":[181],"stress":[182],"systemic":[184],"inflammation.":[185]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
