{"id":"https://openalex.org/W96781616","doi":null,"title":"Aberrant methylation of the CHFR gene in digestive tract cancer.","display_name":"Aberrant methylation of the CHFR gene in digestive tract cancer.","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W96781616","mag":"96781616","pmid":"https://pubmed.ncbi.nlm.nih.gov/16827108"},"language":"en","primary_location":{"id":"pmid:16827108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16827108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110323259","display_name":"Yuki Morioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Morioka","raw_affiliation_strings":["Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111844162","display_name":"Kenji Hibi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenji Hibi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103721842","display_name":"Mitsuru Sakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuru Sakai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102062229","display_name":"Masahiko Koike","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahiko Koike","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087008478","display_name":"Michitaka Fujiwara","orcid":"https://orcid.org/0000-0002-7189-5580","observed_orcids":["https://orcid.org/0000-0002-7189-5580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michitaka Fujiwara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018146056","display_name":"Yasuhiro Kodera","orcid":"https://orcid.org/0000-0002-6173-7474","observed_orcids":["https://orcid.org/0000-0002-6173-7474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiro Kodera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109803217","display_name":"Katsuki Ito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katsuki Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111421675","display_name":"Akimasa Nakao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akimasa Nakao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5614,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.56714322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"26","issue":"3A","first_page":"1791","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/digestive-tract-cancer","display_name":"digestive tract cancer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/clinicopathological-correlation","display_name":"clinicopathological correlation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/gender-differences","display_name":"gender differences","score":0.5839999914169312},{"id":"https://openalex.org/keywords/early-stage-cancer-detection","display_name":"early-stage cancer detection","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.8642988204956055},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6626873016357422},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6625574827194214},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6288262009620667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5336096286773682},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.5106611847877502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4188120663166046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4061793088912964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3244214355945587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2986767292022705},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29517775774002075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17165595293045044}],"mesh":[{"descriptor_ui":"D000075223","descriptor_name":"Poly-ADP-Ribose Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:16827108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16827108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W198571108","https://openalex.org/W1556996865","https://openalex.org/W1602504912","https://openalex.org/W1974190379","https://openalex.org/W1974773964","https://openalex.org/W1977706798","https://openalex.org/W1980017984","https://openalex.org/W1985407849","https://openalex.org/W2011287943","https://openalex.org/W2054823635","https://openalex.org/W2055354487","https://openalex.org/W2075300416","https://openalex.org/W2077709632","https://openalex.org/W2083314068","https://openalex.org/W2091723114","https://openalex.org/W2121880894","https://openalex.org/W2122580718","https://openalex.org/W2144140175","https://openalex.org/W2144936572","https://openalex.org/W2169453999","https://openalex.org/W2169858868","https://openalex.org/W2188033081"],"related_works":["https://openalex.org/W2352908378","https://openalex.org/W1993933640","https://openalex.org/W2018358825","https://openalex.org/W2152070575","https://openalex.org/W2021631287","https://openalex.org/W88306281","https://openalex.org/W2121873993","https://openalex.org/W2912745469","https://openalex.org/W2780602109","https://openalex.org/W4385165346"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recently,":[1],"aberrant":[2],"methylation":[3,19,37,55,76,85,110,151,166,182],"of":[4,21,39,57,86,95,103,112,167],"the":[5,22,40,58,72,78,87,114,116,147,168],"CHFR":[6,23,41,59,75,88,169],"gene":[7,10,24,60,89,170],"associated":[8],"with":[9,121],"silencing":[11],"has":[12],"been":[13],"reported":[14],"in":[15,27,47,61,92,154,174,185],"several":[16],"cancers.":[17,108,178],"The":[18,36,54],"status":[20,38,56],"was":[25,68,81,90,125,152,171,183],"examined":[26,52,70],"primary":[28,98,106],"esophageal":[29,63,99,138,155,175],"and":[30,44,64,71,77,100,156,176],"gastric":[31,66,107,157,177],"carcinomas.":[32],"MATERIALS":[33],"AND":[34],"METHODS:":[35],"promoter":[42],"region":[43],"mRNA":[45],"expression":[46],"cancer":[48,158,187,196],"cell":[49],"lines":[50],"were":[51,119,140],"first.":[53],"38":[62,96],"53":[65,104],"cancers":[67,139],"subsequently":[69],"correlation":[73],"between":[74],"clinicopathological":[79,117],"findings":[80],"investigated.":[82],"RESULTS:":[83],"Aberrant":[84,165],"detected":[91],"9":[93],"out":[94,102],"(24%)":[97],"16":[101],"(30%)":[105],"After":[109],"analysis":[111],"all":[113,161,190],"samples,":[115],"data":[118],"correlated":[120],"these":[122,186],"results.":[123],"There":[124],"a":[126],"significant":[127],"difference":[128],"according":[129],"to":[130],"gender":[131],"(p":[132],"=":[133],"0.0404),":[134],"indicating":[135],"that":[136,194],"female":[137],"more":[141],"frequently":[142,172],"methylated":[143,199],"than":[144],"male.":[145],"On":[146],"other":[148],"hand,":[149],"abnormal":[150,181],"found":[153,184],"patients":[159,188],"at":[160,189,200],"clinical":[162,191],"stages.":[163],"CONCLUSION:":[164],"shown":[173],"In":[179],"addition,":[180],"stages,":[192],"suggesting":[193],"this":[195],"could":[197],"be":[198],"an":[201],"early":[202],"stage.":[203]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
