{"id":"https://openalex.org/W96780237","doi":"https://doi.org/10.1182/blood.v92.4.1165","title":"Long-Term Follow-Up of Patients With Chronic Lymphocytic Leukemia (CLL) Receiving Fludarabine Regimens as Initial Therapy","display_name":"Long-Term Follow-Up of Patients With Chronic Lymphocytic Leukemia (CLL) Receiving Fludarabine Regimens as Initial Therapy","publication_year":1998,"publication_date":"1998-08-15","ids":{"openalex":"https://openalex.org/W96780237","doi":"https://doi.org/10.1182/blood.v92.4.1165","mag":"96780237","pmid":"https://pubmed.ncbi.nlm.nih.gov/9694704"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v92.4.1165","doi":"https://doi.org/10.1182/blood.v92.4.1165","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.4.1165","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027575595","display_name":"Michael J. Keating","orcid":"https://orcid.org/0000-0002-9121-6450","observed_orcids":["https://orcid.org/0000-0002-9121-6450"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.J. Keating","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006104041","display_name":"Susan Mary O'Brien","orcid":"https://orcid.org/0000-0002-2481-7504","observed_orcids":["https://orcid.org/0000-0002-2481-7504"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. O\u2019Brien","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035354255","display_name":"Susan A. Lerner","orcid":"https://orcid.org/0000-0002-5407-4625","observed_orcids":["https://orcid.org/0000-0002-5407-4625"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Lerner","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109438231","display_name":"Charles Asa Koller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Koller","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030171128","display_name":"Miloslav Beran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Beran","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112192765","display_name":"L. E. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.E. Robertson","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111473566","display_name":"Emil J. Freireich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. J Freireich","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057920623","display_name":"Elihu H. Estey","orcid":"https://orcid.org/0000-0002-0987-8077","observed_orcids":["https://orcid.org/0000-0002-0987-8077"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Estey","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Kantarjian","raw_affiliation_strings":["From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":15.7457,"has_fulltext":false,"cited_by_count":434,"citation_normalized_percentile":{"value":0.99446443,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"92","issue":"4","first_page":"1165","last_page":"1171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.7870000004768372},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6499999761581421},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.6809999942779541},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.6449999809265137},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.7310000061988831},{"id":"https://openalex.org/keywords/infection-risk","display_name":"infection risk","score":0.5609999895095825},{"id":"https://openalex.org/keywords/richter-transformation","display_name":"Richter transformation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9110000133514404},{"id":"https://openalex.org/keywords/secondary-malignancies","display_name":"secondary malignancies","score":0.9210000038146973},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.9505429267883301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.870405912399292},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.675540566444397},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6351252198219299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6106305718421936},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.531568706035614},{"id":"https://openalex.org/C2777866208","wikidata":"https://www.wikidata.org/wiki/Q415939","display_name":"Chlorambucil","level":4,"score":0.429796040058136},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4255008101463318},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3726307153701782},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3653695583343506},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31304454803466797},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.2199728786945343},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v92.4.1165","doi":"https://doi.org/10.1182/blood.v92.4.1165","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.4.1165","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v92.4.1165.416k03_1165_1171","doi":"https://doi.org/10.1182/blood.v92.4.1165.416k03_1165_1171","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.4.1165.416k03_1165_1171","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:9694704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9694704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.75}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W3747062","https://openalex.org/W60865865","https://openalex.org/W61714529","https://openalex.org/W1494274243","https://openalex.org/W1635565950","https://openalex.org/W1710792668","https://openalex.org/W1756818535","https://openalex.org/W1862276309","https://openalex.org/W1894269341","https://openalex.org/W1974095075","https://openalex.org/W2017648142","https://openalex.org/W2025334762","https://openalex.org/W2035858908","https://openalex.org/W2037668098","https://openalex.org/W2070193300","https://openalex.org/W2073937764","https://openalex.org/W2079317120","https://openalex.org/W2135806859","https://openalex.org/W2143087936","https://openalex.org/W2176099867","https://openalex.org/W2178644389","https://openalex.org/W2226417367","https://openalex.org/W2272085651","https://openalex.org/W2294516256","https://openalex.org/W2409459554","https://openalex.org/W2414892177","https://openalex.org/W2916663880","https://openalex.org/W6600151109","https://openalex.org/W6693941070"],"related_works":["https://openalex.org/W1635565950","https://openalex.org/W65919465","https://openalex.org/W2182053700","https://openalex.org/W2419468745","https://openalex.org/W2001850157","https://openalex.org/W2025334762","https://openalex.org/W1756818535","https://openalex.org/W2462438592","https://openalex.org/W2166014786","https://openalex.org/W2148900175"],"abstract_inverted_index":{"One":[0],"hundred":[1],"seventy-four":[2],"patients":[3,52,63,119,139,187,248,263,273,294],"with":[4,16,25,60,98,130,203,216,234,255,288,295],"progressive":[5],"or":[6,22,45,213,221],"advanced":[7,99],"chronic":[8],"lymphocytic":[9],"leukemia":[10],"(CLL)":[11],"have":[12],"received":[13,65],"initial":[14,148,285],"therapy":[15,124,287],"fludarabine":[17,23,54,123],"as":[18,55],"a":[19,56,107,143,231,251,289],"single":[20,57],"agent":[21,58],"combined":[24],"prednisone.":[26],"The":[27,69,150],"overall":[28,81],"response":[29,43,253],"rate":[30,44],"was":[31,37,47,76,84,178,184,208],"78%":[32],"and":[33,79,104,152,201,230,264],"the":[34,50,61,80,89,118,160,167,180,217,222,226,235],"median":[35,70,82],"survival":[36,46,83,110],"63":[38],"months.":[39,86],"No":[40],"difference":[41],"in":[42,49,67,138,159,186,188,237,247,261,268],"noted":[48],"71":[51],"receiving":[53],"compared":[59,254],"103":[62],"who":[64,120,140,249],"prednisone":[66],"addition.":[68],"time":[71,204],"to":[72,126,157,164,281],"progression":[73],"of":[74,91,162,171,182,192,211,219,228],"responders":[75],"31":[77],"months":[78],"74":[85],"Patients":[87,97],"over":[88],"age":[90],"70":[92],"years":[93,198],"had":[94,106,141,250],"shorter":[95,109],"survivals.":[96],"stage":[100,113],"disease":[101,266],"(Rai":[102],"III":[103],"IV)":[105],"somewhat":[108],"than":[111,116],"earlier":[112],"patients.":[114,270],"More":[115],"half":[117],"relapsed":[121],"after":[122,166],"responded":[125],"salvage":[127],"treatment,":[128],"usually":[129],"fludarabine-based":[131],"regimens.":[132],"Second":[133],"remissions":[134],"were":[135,244],"more":[136],"common":[137,246],"achieved":[142],"complete":[144,252],"remission":[145,189],"on":[146],"their":[147],"treatment.":[149,172,206],"CD4":[151,223,238],"CD8":[153],"T-lymphocyte":[154],"subpopulations":[155],"decreased":[156,202],"levels":[158,177],"range":[161],"150":[163],"200/microL":[165],"first":[168],"3":[169],"courses":[170],"Although":[173],"recovery":[174],"towards":[175],"normal":[176],"slow,":[179],"incidence":[181],"infections":[183,212],"low":[185],"(1":[190],"episode":[191],"infection":[193],"for":[194,293],"every":[195],"3.33":[196],"patient":[197],"at":[199,225],"risk)":[200],"off":[205],"There":[207],"no":[209],"association":[210],"febrile":[214],"episodes":[215,243],"use":[218],"corticosteroids":[220],"count":[224],"end":[227],"treatment":[229],"poor":[232],"correlation":[233],"increase":[236],"counts":[239],"during":[240],"remission.":[241],"Infectious":[242],"less":[245],"partial":[256],"responders.":[257],"Richter's":[258],"transformation":[259],"occurred":[260,267],"9":[262],"Hodgkin's":[265],"4":[269],"Five":[271],"other":[272,276],"died":[274],"from":[275],"second":[277],"malignancies.":[278],"Fludarabine":[279],"appears":[280],"be":[282],"an":[283],"effective":[284],"induction":[286],"reasonable":[290],"safety":[291],"profile":[292],"CLL.":[296]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}