{"id":"https://openalex.org/W9660048","doi":null,"title":"Up-regulated Reg proteins induced by Interleukin-22 treatment ameliorate acute liver injury in rat model.","display_name":"Up-regulated Reg proteins induced by Interleukin-22 treatment ameliorate acute liver injury in rat model.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W9660048","mag":"9660048","pmid":"https://pubmed.ncbi.nlm.nih.gov/25785121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4358576"},"language":"en","primary_location":{"id":"pmid:25785121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25785121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4358576/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115603898","display_name":"Hongbin Zhang","orcid":"https://orcid.org/0000-0003-4207-0560","observed_orcids":["https://orcid.org/0000-0003-4207-0560"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Bin Zhang","raw_affiliation_strings":["Department of Hemotology, The First Affiliated Hospital of Chongqing Medical University Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemotology, The First Affiliated Hospital of Chongqing Medical University Chongqing, China","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024577852","display_name":"Hongchun Luo","orcid":"https://orcid.org/0000-0001-7807-0103","observed_orcids":["https://orcid.org/0000-0001-7807-0103"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Chun Luo","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050976921","display_name":"Xiao-Juan Xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Juan Xin","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047532135","display_name":"Aizhong Zeng","orcid":"https://orcid.org/0000-0002-3328-3153","observed_orcids":["https://orcid.org/0000-0002-3328-3153"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ai-Zhong Zeng","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1696,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53121358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":"1","first_page":"1253","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.871999979019165},{"id":"https://openalex.org/keywords/reg-protein","display_name":"Reg protein","score":0.7450000047683716},{"id":"https://openalex.org/keywords/reg-iv","display_name":"Reg IV","score":0.7910000085830688},{"id":"https://openalex.org/keywords/acute-liver-injury","display_name":"acute liver injury","score":0.8360000252723694},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.9480000138282776},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.7289999723434448},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7860000133514404},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6240000128746033},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.42100000381469727},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.659014105796814},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5977083444595337},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5915442109107971},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.45822322368621826},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.45226800441741943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44091588258743286},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35019999742507935},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.33249664306640625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3064672350883484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19515016674995422},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.14084947109222412},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10285460948944092},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08906254172325134}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:25785121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25785121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4358576","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4358576/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:9660048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25785121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4358576","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4358576/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1531601693","https://openalex.org/W1576903429","https://openalex.org/W1752683265","https://openalex.org/W1983205679","https://openalex.org/W1987389251","https://openalex.org/W1994509817","https://openalex.org/W2005359518","https://openalex.org/W2013349369","https://openalex.org/W2016031589","https://openalex.org/W2025421728","https://openalex.org/W2031038184","https://openalex.org/W2033283529","https://openalex.org/W2036312906","https://openalex.org/W2040015333","https://openalex.org/W2043493252","https://openalex.org/W2053820570","https://openalex.org/W2055060301","https://openalex.org/W2056005334","https://openalex.org/W2062564526","https://openalex.org/W2075848641","https://openalex.org/W2077627123","https://openalex.org/W2085457180","https://openalex.org/W2092701974","https://openalex.org/W2093005090","https://openalex.org/W2093739693","https://openalex.org/W2102754351","https://openalex.org/W2104201959","https://openalex.org/W2107066107","https://openalex.org/W2120420911","https://openalex.org/W2125410679","https://openalex.org/W2135261346","https://openalex.org/W2139121810","https://openalex.org/W2143076511","https://openalex.org/W2143364414","https://openalex.org/W2147833105","https://openalex.org/W4211223836"],"related_works":["https://openalex.org/W2899379982","https://openalex.org/W2270525566","https://openalex.org/W2473565432","https://openalex.org/W3040671986","https://openalex.org/W2774405937","https://openalex.org/W2147833105","https://openalex.org/W2767556394","https://openalex.org/W2139121810","https://openalex.org/W3050051861","https://openalex.org/W3031799741"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"regenerating":[2,14],"gene":[3],"(Reg),":[4],"encoding":[5],"lectin-related":[6],"protein,":[7,236,250,254],"was":[8,109],"originally":[9],"isolated":[10],"from":[11],"a":[12,19,68,88,154,242,258],"rat":[13,69,89,155,210,218,243],"pancreatic":[15],"islets.":[16],"Interleukin-22":[17],"(IL-22),":[18],"recently":[20],"identified":[21],"cytokine,":[22],"is":[23,50,56],"produced":[24],"by":[25,149],"Th":[26],"17":[27],"cells":[28],"and":[29,61,95,205,237],"natural":[30],"killer":[31],"cells.":[32],"Both":[33],"of":[34,64,71,81,91,99,115,136,157,164,200,227,245,261,269],"them":[35],"have":[36],"been":[37],"shown":[38],"to":[39,111],"play":[40],"an":[41],"important":[42],"role":[43],"in":[44,58,67,87,209,217,230,241,265],"controlling":[45],"tissue":[46],"repair.":[47],"But,":[48],"it":[49],"unclear":[51],"whether":[52],"the":[53,62,78,97,113,130,133,161,225,266],"IL-22/Reg":[54],"axis":[55],"involved":[57],"liver":[59,65,73,93,104,159,211,219,231,239,247,270],"regeneration":[60],"improvement":[63],"function":[66],"model":[70,90,156,244],"acute":[72,92,103,158,246],"injury.":[74,105,248,271],"AIMS:":[75],"We":[76],"investigated":[77],"expression":[79,134,162],"levels":[80,135,163,199,208,216],"Reg":[82,100,116,118,120,165,167,169,187,228,234,249,252],"proteins":[83,101,122,171,229],"after":[84,123,174],"IL-22":[85,177,194,222,264],"stimulation":[86,223],"injury,":[94,160],"estimated":[96],"effects":[98],"ameliorating":[102],"METHODS:":[106],"Western":[107],"blot":[108],"used":[110],"measure":[112],"expressions":[114,226],"I,":[117,166],"III,":[119,168],"IV":[121,170,188,235,253],"treatment":[124,175,182,192],"with":[125,176,181,183,193],"recombinant":[126,178,195],"lentivirus":[127,179,196],"IL-22.":[128],"At":[129],"same":[131],"time,":[132],"TB,":[137,201],"ALT,":[138,202],"AST,":[139,203],"endotoxin":[140],"(ETM),":[141],"superoxide":[142],"dismutase":[143],"(SOD),":[144],"malondialdehyde":[145],"(MDA)":[146],"were":[147,172],"detected":[148],"related":[150],"reagents.":[151],"RESULTS:":[152],"In":[153],"increased":[173,214],"compared":[180],"lentivirus-empty":[184],"vector,":[185],"especially,":[186,233],"protein":[189],"expression.":[190],"Meanwhile,":[191],"reduced":[197],"serum":[198],"ETM,":[204],"decreased":[206],"MAD":[207],"tissues,":[212],"but":[213],"SOD":[215],"tissues.":[220],"CONCLUSION:":[221],"enhanced":[224],"cell,":[232],"ameliorated":[238],"injury":[240],"especially":[251],"might":[255],"act":[256],"as":[257],"biological":[259],"mediator":[260],"immune":[262],"cell-derived":[263],"recovering":[267],"mechanism":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
