{"id":"https://openalex.org/W96560643","doi":null,"title":"p53 influences mice skeletal development.","display_name":"p53 influences mice skeletal development.","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W96560643","mag":"96560643","pmid":"https://pubmed.ncbi.nlm.nih.gov/9493073"},"language":"en","primary_location":{"id":"pmid:9493073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9493073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of craniofacial genetics and developmental biology","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W96560643"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111585227","display_name":"Kazuhiko Ohyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Ohyama","raw_affiliation_strings":["Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114259952","display_name":"C H Chung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C H Chung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050268877","display_name":"E Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030200092","display_name":"C W Gibson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Gibson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007324726","display_name":"Katharina Misof","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Misof","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025231754","display_name":"Peter Fratzl","orcid":"https://orcid.org/0000-0003-4437-7830","observed_orcids":["https://orcid.org/0000-0003-4437-7830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Fratzl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019521528","display_name":"Irving M. Shapiro","orcid":"https://orcid.org/0000-0001-5799-6142","observed_orcids":["https://orcid.org/0000-0001-5799-6142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I M Shapiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2977,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.46258452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"4","first_page":"161","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0835999995470047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.9390000104904175},{"id":"https://openalex.org/keywords/exencephaly","display_name":"exencephaly","score":0.8299999833106995},{"id":"https://openalex.org/keywords/hyoid-bone","display_name":"hyoid bone","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.6990000009536743},{"id":"https://openalex.org/keywords/chondrocyte-apoptosis","display_name":"chondrocyte apoptosis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cartilage-maturation","display_name":"cartilage maturation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/heterozygous-mice","display_name":"heterozygous mice","score":0.6949999928474426},{"id":"https://openalex.org/keywords/homozygous-mice","display_name":"homozygous mice","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6388654112815857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5338493585586548},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.5220860838890076},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.44863787293434143},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42972102761268616},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4168321192264557},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.39848804473876953},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.37354594469070435},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.31163549423217773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20826053619384766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13029956817626953}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001848","descriptor_name":"Bone Diseases, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019465","descriptor_name":"Craniofacial Abnormalities","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:9493073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9493073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of craniofacial genetics and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:escidoc.org:escidoc:2167817","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0027-B4A1-8","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2167817","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0027-B4A1-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Craniofacial Genetics and Development Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:96560643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9493073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1763916415","display_name":"BONE GROWTH IN DENTAL, CRANIAL AND SKELETAL TISSUES","funder_award_id":"R01DE010875","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4239900885","https://openalex.org/W2010982809","https://openalex.org/W2082094973","https://openalex.org/W82773244","https://openalex.org/W2909645751","https://openalex.org/W2056079046","https://openalex.org/W1967698481","https://openalex.org/W2132764095","https://openalex.org/W2280655896","https://openalex.org/W2409307060"],"abstract_inverted_index":{"The":[0],"p53":[1,47,75],"tumor":[2],"suppressor":[3],"gene":[4,48],"encodes":[5],"a":[6,25,240,247],"transcriptional":[7],"activator":[8],"whose":[9],"targets":[10],"include":[11],"genes":[12],"that":[13,24,89,235,257,262],"regulate":[14],"cell":[15,37],"cycle":[16],"progression":[17],"and":[18,60,102,109,147,154,271,282],"apoptosis.":[19],"Since":[20,210],"we":[21,39,179,233,255],"have":[22],"shown":[23],"critical":[26],"event":[27],"in":[28,118,144,151,160,185,242,249,260,265],"the":[29,33,41,46,68,74,87,91,99,106,110,114,119,123,133,140,152,157,181,186,191,195,199,207,211,223,228,236,274,277],"life":[30],"history":[31],"of":[32,45,73,84,86,98,105,121,125,156,183,198,206,225,227,276,280],"chondrocyte":[34,250],"is":[35],"programmed":[36],"death,":[38],"asked":[40],"question:":[42],"does":[43],"loss":[44,97],"influence":[49],"skeletogenesis?":[50],"Female":[51],"p53(+/-)":[52,57],"mice":[53,59,63,261,284],"were":[54,64,169],"mated":[55],"with":[56,137],"male":[58],"17-day-old":[61],"fetal":[62],"studied.":[65],"Exencephaly":[66],"was":[67,80,95,128,203,219],"most":[69],"profound":[70],"skeletal":[71,126],"defect":[72,79,238],"null":[76,138],"mutation.":[77],"This":[78],"due":[81],"to":[82,171,222],"failure":[83],"formation":[85],"bones":[88,279],"comprise":[90],"mouse":[92],"calvarium.":[93],"There":[94],"also":[96],"hyoid":[100],"bone,":[101,162],"defective":[103],"mineralization":[104],"manubrium":[107],"sternum":[108],"terminal":[111],"phalanges.":[112],"In":[113,194],"homozygous":[115],"state":[116],"(-/-),":[117],"absence":[120],"exencephaly,":[122],"number":[124],"deformities":[127],"markedly":[129],"reduced.":[130],"Aside":[131],"from":[132],"gross":[134],"changes":[135],"associated":[136],"status,":[139],"mutants":[141],"exhibited":[142],"alterations":[143],"bone":[145,266],"length":[146,267,275],"width.":[148],"Small":[149],"differences":[150,264],"size":[153],"orientation":[155],"mineral":[158],"crystals":[159],"embryonic":[161],"as":[163],"evaluated":[164,180],"by":[165],"small-angle":[166],"X-ray":[167],"scattering,":[168],"found":[170],"disappear":[172],"after":[173,258],"birth.":[174],"To":[175],"explain":[176],"these":[177],"observations,":[178],"extent":[182],"apoptosis":[184],"tibial":[187],"growth":[188,196,237],"plates":[189],"using":[190],"TUNEL":[192,213],"stain.":[193],"plate":[197],"p53(-/-)":[200,212],"homozygote,":[201],"there":[202],"minimal":[204],"labeling":[205,226],"hypertrophic":[208],"layer.":[209],"stain":[214],"pattern":[215,224],"at":[216,230,272],"17":[217],"days":[218],"very":[220],"similar":[221],"p53(+/+)":[229],"15":[231],"days,":[232],"concluded":[234],"reflected":[239],"delay":[241],"cartilage":[243],"maturation":[244],"rather":[245],"than":[246],"change":[248],"phenotype.":[251],"On":[252],"this":[253],"basis,":[254],"predict":[256],"birth,":[259],"survive,":[263],"would":[268,285],"become":[269],"minimal,":[270],"maturity,":[273],"long":[278],"(+/+)":[281],"(-/-)":[283],"be":[286],"similar.":[287]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
