{"id":"https://openalex.org/W96535518","doi":"https://doi.org/10.1007/978-3-662-06214-2_9","title":"The Genetics of Cardiac Channelopathies: Implications for Therapeutics","display_name":"The Genetics of Cardiac Channelopathies: Implications for Therapeutics","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W96535518","doi":"https://doi.org/10.1007/978-3-662-06214-2_9","mag":"96535518"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-662-06214-2_9","doi":"https://doi.org/10.1007/978-3-662-06214-2_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-662-06214-2_9","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4249281539","display_name":"Cardiovascular Pharmacogenetics"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058141203","display_name":"Dan M. Roden","orcid":"https://orcid.org/0000-0002-6302-0389","observed_orcids":["https://orcid.org/0000-0002-6302-0389"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. M. Roden","raw_affiliation_strings":["Division of Clinical Pharmacology, Vanderbilt University School of Medicine, 532 Robinson Research Building, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Vanderbilt University School of Medicine, 532 Robinson Research Building, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058141203"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0544518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"223","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-channelopathies","display_name":"cardiac channelopathies","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-induced-arrhythmia","display_name":"drug-induced arrhythmia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drug-induced-long-qt-syndrome","display_name":"drug-induced long QT syndrome","score":0.9570000171661377},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6029999852180481},{"id":"https://openalex.org/keywords/ion-channel-genes","display_name":"ion channel genes","score":0.5789999961853027},{"id":"https://openalex.org/keywords/idiosyncratic-adverse-drug-reactions","display_name":"idiosyncratic drug reactions","score":0.7940000295639038},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2777008848","wikidata":"https://www.wikidata.org/wiki/Q7246836","display_name":"Proarrhythmia","level":3,"score":0.9128011465072632},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6542534232139587},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.5811132192611694},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.579778254032135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5433188080787659},{"id":"https://openalex.org/C2780310539","wikidata":"https://www.wikidata.org/wiki/Q12547192","display_name":"Imperfect","level":2,"score":0.43236881494522095},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3272325098514557},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3137262463569641},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.236673504114151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20219600200653076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14282283186912537},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.10238459706306458},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-662-06214-2_9","doi":"https://doi.org/10.1007/978-3-662-06214-2_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-662-06214-2_9","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W220488953","https://openalex.org/W1491803208","https://openalex.org/W1963748793","https://openalex.org/W1963890550","https://openalex.org/W1964700699","https://openalex.org/W1967666633","https://openalex.org/W1968098810","https://openalex.org/W1969575386","https://openalex.org/W1970861241","https://openalex.org/W1973522972","https://openalex.org/W1974359854","https://openalex.org/W1980361970","https://openalex.org/W1981468825","https://openalex.org/W1991290782","https://openalex.org/W1991662012","https://openalex.org/W2000733439","https://openalex.org/W2005411701","https://openalex.org/W2006214313","https://openalex.org/W2008125074","https://openalex.org/W2008527258","https://openalex.org/W2018409817","https://openalex.org/W2018841001","https://openalex.org/W2019973925","https://openalex.org/W2022414157","https://openalex.org/W2022422805","https://openalex.org/W2023888444","https://openalex.org/W2029209225","https://openalex.org/W2029433670","https://openalex.org/W2031237455","https://openalex.org/W2034646721","https://openalex.org/W2035106953","https://openalex.org/W2040165185","https://openalex.org/W2042145198","https://openalex.org/W2043707154","https://openalex.org/W2046508780","https://openalex.org/W2052085254","https://openalex.org/W2052976216","https://openalex.org/W2055896381","https://openalex.org/W2057206255","https://openalex.org/W2061967268","https://openalex.org/W2065288202","https://openalex.org/W2066742955","https://openalex.org/W2074705578","https://openalex.org/W2075795860","https://openalex.org/W2081517567","https://openalex.org/W2082626069","https://openalex.org/W2085873341","https://openalex.org/W2088143209","https://openalex.org/W2091453055","https://openalex.org/W2093638125","https://openalex.org/W2097912415","https://openalex.org/W2100477955","https://openalex.org/W2106411488","https://openalex.org/W2107763854","https://openalex.org/W2107958165","https://openalex.org/W2116051448","https://openalex.org/W2121570319","https://openalex.org/W2121660436","https://openalex.org/W2125271591","https://openalex.org/W2127815448","https://openalex.org/W2129529218","https://openalex.org/W2129910735","https://openalex.org/W2131764386","https://openalex.org/W2131871260","https://openalex.org/W2135080211","https://openalex.org/W2139184929","https://openalex.org/W2144423360","https://openalex.org/W2145166035","https://openalex.org/W2148036689","https://openalex.org/W2150114083","https://openalex.org/W2156048327","https://openalex.org/W2160137065","https://openalex.org/W2168256522","https://openalex.org/W2180517827","https://openalex.org/W2279053372","https://openalex.org/W2330959938","https://openalex.org/W2331899980","https://openalex.org/W2334363451","https://openalex.org/W2471757827","https://openalex.org/W2614168425","https://openalex.org/W3021677959"],"related_works":["https://openalex.org/W2011299051","https://openalex.org/W2111658406","https://openalex.org/W2019277255","https://openalex.org/W2040423688","https://openalex.org/W62765588","https://openalex.org/W98383371","https://openalex.org/W2069310511","https://openalex.org/W605867460","https://openalex.org/W2795599936","https://openalex.org/W1976892262"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}