{"id":"https://openalex.org/W96478620","doi":null,"title":"Circulating tumor cells and serum tumor biomarkers in small cell lung cancer.","display_name":"Circulating tumor cells and serum tumor biomarkers in small cell lung cancer.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W96478620","mag":"96478620","pmid":"https://pubmed.ncbi.nlm.nih.gov/12683352"},"language":"en","primary_location":{"id":"pmid:12683352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12683352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Patrick C Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick C Ma","raw_affiliation_strings":["Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Womens's Hospital, Harvard Medical School, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Womens's Hospital, Harvard Medical School, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I1290900354","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081543892","display_name":"Lawrence Scott Blaszkowsky","orcid":"https://orcid.org/0000-0002-9437-2977","observed_orcids":["https://orcid.org/0000-0002-9437-2977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence Blaszkowsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007319541","display_name":"Ajit K. Bharti","orcid":"https://orcid.org/0000-0001-7972-6688","observed_orcids":["https://orcid.org/0000-0001-7972-6688"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajit Bharti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063822465","display_name":"Andr\u00e1s Lad\u00e1nyi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andras Ladanyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108622638","display_name":"Stine\u2010Kathrein Kraeft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stine-Kathrein Kraeft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070112311","display_name":"Adam Bruno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Bruno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000279745","display_name":"Arthur T. Skarin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arthur T Skarin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109866698","display_name":"Lan Bo Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Bo Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003826371","display_name":"Ravi Salgia","orcid":"https://orcid.org/0000-0001-9643-7626","observed_orcids":["https://orcid.org/0000-0001-9643-7626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi Salgia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1125,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.85795821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"1A","first_page":"49","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":1.0},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.9710000157356262},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chromogranin-a","display_name":"chromogranin A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":1.0},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.8550000190734863},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.968999981880188},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.7900000214576721},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.9620000123977661},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.7120000123977661},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.7609999775886536},{"id":"https://openalex.org/keywords/genomics","display_name":"genomics","score":0.781000018119812},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6860114932060242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5815811157226562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5600376725196838},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.549901008605957},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.5326558947563171},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5291272401809692},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.49948596954345703},{"id":"https://openalex.org/C77231918","wikidata":"https://www.wikidata.org/wiki/Q3698322","display_name":"Chromogranin A","level":3,"score":0.46531179547309875},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46102625131607056},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4596197009086609},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.44954296946525574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39436107873916626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3349250257015228},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.18719246983528137},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.12538263201713562},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.12194660305976868},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12683352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12683352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:96478620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12683352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125882530","https://openalex.org/W7098149960","https://openalex.org/W1990771079","https://openalex.org/W3199201927","https://openalex.org/W2990395892","https://openalex.org/W4400292825","https://openalex.org/W2590467245","https://openalex.org/W4391812093","https://openalex.org/W2742764064","https://openalex.org/W2127787661"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,8,17,38],"accounts":[2,29],"for":[3,30,173],"approximately":[4],"30%":[5],"of":[6,33,35,46,55,65,72,81,95,111,113,134,195,212],"all":[7,34],"mortalities":[9],"in":[10,59,88,99,170,204],"the":[11,36,63,78,127,171,181],"United":[12],"States.":[13],"Small":[14],"cell":[15,90,156],"lung":[16,37,91],"(SCLC),":[18],"which":[19],"is":[20,57,75,101,190],"an":[21],"aggressive":[22],"malignancy":[23],"with":[24,40,49,108,116,214],"frequent":[25],"and":[26,85,119,131,140,159,176,184,200,209],"early":[27,206],"metastases,":[28],"about":[31],"15%":[32],"cases":[39],"a":[41],"dismal":[42],"5-year":[43],"survival":[44],"rate":[45],"<":[47],"5%":[48],"current":[50,79,124],"standard":[51],"therapies.":[52],"Early":[53],"detection":[54,112],"SCLC":[56,213],"challenging,":[58],"part":[60],"due":[61],"to":[62,76],"lack":[64],"adequate":[66],"serum":[67,86,129],"tumor":[68,83,97,132],"markers.":[69],"The":[70,93,123],"goal":[71],"this":[73],"review":[74],"summarize":[77],"knowledge":[80,125],"circulating":[82,96],"cells":[84,98,115],"biomarkers":[87,133],"small":[89],"cancer.":[92],"role":[94],"prognostication":[100,208],"controversial,":[102],"but":[103],"may":[104],"be":[105,144],"better":[106],"defined":[107],"advancing":[109],"technologies":[110,186,201],"such":[114,136,148],"higher":[117],"precision,":[118],"improved":[120,205],"clinico-pathological":[121],"correlations.":[122],"on":[126],"known":[128],"cytokines":[130],"SCLC,":[135],"as":[137,149],"CEA,":[138],"chromogranin-A":[139],"neuron-specific":[141],"enolase":[142],"will":[143,202],"presented.":[145],"Serum":[146],"cytokines,":[147],"vascular":[150],"endothelial":[151],"growth":[152,161],"factor":[153,157,163],"(VEGF),":[154],"stem":[155],"(SCF)":[158],"hepatocyte":[160],"factor/scatter":[162],"(HGF/SF)":[164],"are":[165,187],"also":[166],"discussed.":[167],"New":[168],"findings":[169],"search":[172],"novel":[174,216],"diagnostic":[175],"therapeutic":[177],"molecular":[178],"markers":[179],"using":[180],"emerging":[182],"genomics":[183],"proteomics":[185],"emphasized.":[188],"It":[189],"our":[191],"hope":[192],"that":[193],"validation":[194],"these":[196],"new":[197],"research":[198],"platforms":[199],"result":[203],"detection,":[207],"finally":[210],"treatment":[211],"potential":[215],"molecularly-targeted":[217],"therapeutics.":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
