{"id":"https://openalex.org/W96464353","doi":null,"title":"MicroRNA-19a promotes glioma cell growth by repressing LRIG1.","display_name":"MicroRNA-19a promotes glioma cell growth by repressing LRIG1.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W96464353","mag":"96464353","pmid":"https://pubmed.ncbi.nlm.nih.gov/25664006","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4307453"},"language":"en","primary_location":{"id":"pmid:25664006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307453/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007113609","display_name":"Lingmin Shao","orcid":"https://orcid.org/0000-0002-9547-2128","observed_orcids":["https://orcid.org/0000-0002-9547-2128"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Min Shao","raw_affiliation_strings":["Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644506","display_name":"Jian Yang","orcid":"https://orcid.org/0000-0003-2679-9095","observed_orcids":["https://orcid.org/0000-0003-2679-9095"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-An Yang","raw_affiliation_strings":["Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yue-Fei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-Fei Wang","raw_affiliation_strings":["Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101722221","display_name":"Peng Wu","orcid":"https://orcid.org/0009-0006-0949-7289","observed_orcids":["https://orcid.org/0009-0006-0949-7289"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Wu","raw_affiliation_strings":["Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101934497","display_name":"Jiqiang Li","orcid":"https://orcid.org/0000-0002-0962-9118","observed_orcids":["https://orcid.org/0000-0002-0962-9118"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Qiang Li","raw_affiliation_strings":["Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108064843","display_name":"Qianxue Chen","orcid":"https://orcid.org/0000-0002-9413-1030","observed_orcids":["https://orcid.org/0000-0002-9413-1030"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian-Xue Chen","raw_affiliation_strings":["Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Renmin Hospital of Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140357"],"apc_list":null,"apc_paid":null,"fwci":0.1021,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.44021019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"7","issue":"12","first_page":"5067","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrig1","display_name":"Lrig1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.7110000252723694},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/glioma-cell-proliferation","display_name":"glioma cell proliferation","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.889035701751709},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8759074807167053},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7898472547531128},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7357121109962463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5837005376815796},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5411251783370972},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5072038173675537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5052724480628967},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.48767340183258057},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43992921710014343},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43973231315612793},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.41777315735816956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3850363492965698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3055376410484314},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.19790518283843994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.127282977104187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11401024460792542},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10800200700759888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08713185787200928}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:25664006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4307453","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307453/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:96464353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4307453","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307453/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1964582717","https://openalex.org/W1978802569","https://openalex.org/W2006575609","https://openalex.org/W2014946489","https://openalex.org/W2021936364","https://openalex.org/W2025183726","https://openalex.org/W2026263665","https://openalex.org/W2029738976","https://openalex.org/W2046674021","https://openalex.org/W2049969188","https://openalex.org/W2064316340","https://openalex.org/W2068915942","https://openalex.org/W2074174719","https://openalex.org/W2082337923","https://openalex.org/W2089937396","https://openalex.org/W2111990378","https://openalex.org/W2115862526","https://openalex.org/W2116365126","https://openalex.org/W2119004691","https://openalex.org/W2124756133","https://openalex.org/W2144753743","https://openalex.org/W2153322850","https://openalex.org/W2154932881","https://openalex.org/W2155140015","https://openalex.org/W2156425837","https://openalex.org/W4255289481"],"related_works":["https://openalex.org/W2472588569","https://openalex.org/W3031243539","https://openalex.org/W2943223007","https://openalex.org/W2983450592","https://openalex.org/W2039979225","https://openalex.org/W2063954888","https://openalex.org/W3028807183","https://openalex.org/W2579621828","https://openalex.org/W2128928017","https://openalex.org/W1995689125"],"abstract_inverted_index":{"Growing":[0],"evidence":[1],"indicates":[2],"that":[3,18,66,92],"deregulation":[4],"of":[5,11,21,34,49,72,77,84,94,100],"miRNAs":[6],"contributes":[7],"to":[8],"the":[9,19,47,81,98],"development":[10],"glioma.":[12],"In":[13,74],"present":[14],"study,":[15],"we":[16],"found":[17],"level":[20],"miRNA-19a":[22,35,59,85,95],"was":[23,56,68],"significantly":[24],"elevated":[25],"in":[26,41,44,54,105],"glioma":[27,38,101],"tissues":[28],"and":[29,43],"cell":[30,39],"lines.":[31],"Moreover,":[32],"down-regulation":[33,93],"dramatically":[36],"repressed":[37],"growth":[40,99],"vitro":[42],"vivo.":[45],"Meanwhile,":[46],"expression":[48],"LRIG1,":[50],"a":[51,69],"tumor":[52],"suppressor":[53],"glioma,":[55],"increased":[57],"following":[58],"knockdown.":[60],"Furthermore,":[61],"luciferase":[62],"reporter":[63],"assay":[64],"confirmed":[65],"LRIG1":[67,78],"direct":[70],"target":[71],"miRNA-19a.":[73],"addition,":[75],"silencing":[76],"could":[79,96],"reverse":[80],"suppressive":[82],"effect":[83],"inhibitor.":[86],"Taken":[87],"together,":[88],"our":[89],"results":[90],"demonstrated":[91],"suppress":[97],"cells,":[102],"at":[103],"least":[104],"part,":[106],"through":[107],"up-regulating":[108],"LRIG1.":[109]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}