{"id":"https://openalex.org/W96447876","doi":"https://doi.org/10.1023/a:1005962224801","title":"An in vitro assessment of the antineoplastic potential of 2H-1,3-Oxazine-2,6(3H)-dione (3-oxauracil), a novel pyrimidine","display_name":"An in vitro assessment of the antineoplastic potential of 2H-1,3-Oxazine-2,6(3H)-dione (3-oxauracil), a novel pyrimidine","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W96447876","doi":"https://doi.org/10.1023/a:1005962224801","mag":"96447876","pmid":"https://pubmed.ncbi.nlm.nih.gov/9547671"},"language":"en","primary_location":{"id":"doi:10.1023/a:1005962224801","doi":"https://doi.org/10.1023/a:1005962224801","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1005962224801","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059235870","display_name":"Lawton A. Seal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289568071","display_name":"Brooke Army Medical Center","ror":"https://ror.org/00m1mwc36","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289568071","https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawton Seal","raw_affiliation_strings":["Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas, USA","institution_ids":["https://openalex.org/I1289568071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080900202","display_name":"Daniel D. Von Hoff","orcid":"https://orcid.org/0000-0003-4723-7681","observed_orcids":["https://orcid.org/0000-0003-4723-7681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Von Hoff","raw_affiliation_strings":["Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, Texas, USA","Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, Texas, USA","institution_ids":[]},{"raw_affiliation_string":"Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106923349","display_name":"Richard A Lawrence","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Lawrence","raw_affiliation_strings":["Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, Texas, USA","Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, Texas, USA","institution_ids":[]},{"raw_affiliation_string":"Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039359398","display_name":"El\u017cbieta Izbicka","orcid":"https://orcid.org/0000-0002-8994-1303","observed_orcids":["https://orcid.org/0000-0002-8994-1303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elzbieta Izbicka","raw_affiliation_strings":["Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, Texas, USA","Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, Texas, USA","institution_ids":[]},{"raw_affiliation_string":"Cancer Therapy & Research Center, Institute for Drug Development, San Antonio, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042235804","display_name":"Richard M. Jamison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Jamison","raw_affiliation_strings":["Department of Pediatrics, Louisiana State University Medical Center, Shereveport, Los Angeles, USA","Department of Pediatrics, Louisiana State University Medical Center, Shereveport, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Louisiana State University Medical Center, Shereveport, Los Angeles, USA","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Department of Pediatrics, Louisiana State University Medical Center, Shereveport, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.00270061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"4","first_page":"289","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.48750001192092896,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.48750001192092896,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.18770000338554382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.14900000393390656,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uracil-analogues","display_name":"uracil analogues","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neuroendocrine-cancer","display_name":"neuroendocrine cancer","score":0.875},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7720102071762085},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6746063232421875},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5885087847709656},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5247321724891663},{"id":"https://openalex.org/C2779554091","wikidata":"https://www.wikidata.org/wiki/Q182990","display_name":"Uracil","level":3,"score":0.4823310077190399},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47850385308265686},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.4649578034877777},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.43609195947647095},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43419113755226135},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.4177525043487549},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.41488543152809143},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4104490876197815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38481462001800537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3243781328201294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3215099573135376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2977259159088135},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27537551522254944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19875627756118774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010078","descriptor_name":"Oxazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1005962224801","doi":"https://doi.org/10.1023/a:1005962224801","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1005962224801","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:9547671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9547671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1512563776","https://openalex.org/W1549924695","https://openalex.org/W1559529600","https://openalex.org/W2025797847","https://openalex.org/W2076890039","https://openalex.org/W2113686562","https://openalex.org/W2149319739","https://openalex.org/W2320544708","https://openalex.org/W2406594042","https://openalex.org/W2411577369","https://openalex.org/W2412322165","https://openalex.org/W2415870230"],"related_works":["https://openalex.org/W2415870230","https://openalex.org/W2412322165","https://openalex.org/W1549924695","https://openalex.org/W155842059","https://openalex.org/W2413964278","https://openalex.org/W4362506044","https://openalex.org/W4379145218","https://openalex.org/W4402732815","https://openalex.org/W7117674460","https://openalex.org/W3047948978"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
