{"id":"https://openalex.org/W9635739","doi":"https://doi.org/10.1182/blood.v92.12.4581","title":"Improving the Outcome of Bone Marrow Transplantation by Using CD52 Monoclonal Antibodies to Prevent Graft-Versus-Host Disease and Graft Rejection","display_name":"Improving the Outcome of Bone Marrow Transplantation by Using CD52 Monoclonal Antibodies to Prevent Graft-Versus-Host Disease and Graft Rejection","publication_year":1998,"publication_date":"1998-12-15","ids":{"openalex":"https://openalex.org/W9635739","doi":"https://doi.org/10.1182/blood.v92.12.4581","mag":"9635739","pmid":"https://pubmed.ncbi.nlm.nih.gov/9845524"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v92.12.4581","doi":"https://doi.org/10.1182/blood.v92.12.4581","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.12.4581","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000120418","display_name":"G Hale","orcid":"https://orcid.org/0000-0001-9473-423X","observed_orcids":["https://orcid.org/0000-0001-9473-423X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geoff Hale","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101695996","display_name":"Mei\u2010Jie Zhang","orcid":"https://orcid.org/0000-0002-8868-5184","observed_orcids":["https://orcid.org/0000-0002-8868-5184","https://orcid.org/0000-0001-7705-1090"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mei-Jie Zhang","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002578778","display_name":"Donald Werner Bunjes","orcid":"https://orcid.org/0000-0002-1952-5443","observed_orcids":["https://orcid.org/0000-0002-1952-5443"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Donald Bunjes","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112004060","display_name":"Hugh Grant Prentice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. Grant Prentice","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076895533","display_name":"David James Spence","orcid":"https://orcid.org/0000-0001-5974-853X","observed_orcids":["https://orcid.org/0000-0001-5974-853X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Spence","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091433944","display_name":"Mary M. Horowitz","orcid":"https://orcid.org/0000-0002-9502-785X","observed_orcids":["https://orcid.org/0000-0002-9502-785X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mary M. Horowitz","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112763619","display_name":"A. John Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. John Barrett","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107461980","display_name":"Herman Waldmann","orcid":"https://orcid.org/0000-0001-7519-6720","observed_orcids":["https://orcid.org/0000-0001-7519-6720"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Herman Waldmann","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":9.6639,"has_fulltext":false,"cited_by_count":194,"citation_normalized_percentile":{"value":0.98620394,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"92","issue":"12","first_page":"4581","last_page":"4590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd52-monoclonal-antibody","display_name":"CD52 monoclonal antibody","score":0.8679999709129333},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.9769999980926514},{"id":"https://openalex.org/keywords/allogeneic-bone-marrow-transplantation","display_name":"allogeneic bone marrow transplantation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hla-matched-sibling-donor","display_name":"matched sibling donor","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8320000171661377},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.8610000014305115},{"id":"https://openalex.org/keywords/leukemia-relapse","display_name":"leukemia relapse","score":0.8949999809265137},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2778384904","wikidata":"https://www.wikidata.org/wiki/Q21108353","display_name":"CD52","level":4,"score":0.834004282951355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7887231111526489},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6158342361450195},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5923930406570435},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5522593259811401},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.501854419708252},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4644603133201599},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4644043445587158},{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.44302335381507874},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4374803602695465},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43074238300323486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4228418469429016},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42219915986061096}],"mesh":[{"descriptor_ui":"D000074323","descriptor_name":"Alemtuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074323","descriptor_name":"Alemtuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074323","descriptor_name":"Alemtuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019172","descriptor_name":"Transplantation Conditioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019172","descriptor_name":"Transplantation Conditioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019172","descriptor_name":"Transplantation Conditioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood.v92.12.4581","doi":"https://doi.org/10.1182/blood.v92.12.4581","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.12.4581","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v92.12.4581.424k22_4581_4590","doi":"https://doi.org/10.1182/blood.v92.12.4581.424k22_4581_4590","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.12.4581.424k22_4581_4590","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:9845524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9845524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.703.3415","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.703.3415","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://users.path.ox.ac.uk/%7Escobbold/tig/PDFs/hale98.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G504766879","display_name":null,"funder_award_id":"P01-CA-40053","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G737825680","display_name":"COLLABORATIVE BONE MARROW TRANSPLANT PROGRAM","funder_award_id":"5p01ca040053-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306211","display_name":"Samuel Roberts Noble Foundation","ror":"https://ror.org/02zta5505"},{"id":"https://openalex.org/F4320306490","display_name":"RGK Foundation","ror":"https://ror.org/02vp2wp62"},{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308849","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31"},{"id":"https://openalex.org/F4320309137","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16"},{"id":"https://openalex.org/F4320309515","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320309846","display_name":"Blue Cross and Blue Shield Association","ror":"https://ror.org/02jcrd051"},{"id":"https://openalex.org/F4320310177","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478"},{"id":"https://openalex.org/F4320310179","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83"},{"id":"https://openalex.org/F4320310223","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60"},{"id":"https://openalex.org/F4320310312","display_name":"Intermountain Research and Medical Foundation","ror":"https://ror.org/04mvr1r74"},{"id":"https://openalex.org/F4320310395","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57"},{"id":"https://openalex.org/F4320313505","display_name":"Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation","ror":"https://ror.org/05r5zfp34"},{"id":"https://openalex.org/F4320320104","display_name":"Kay Kendall Leukaemia Fund","ror":"https://ror.org/03j2wfg84"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332607","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338082","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80"},{"id":"https://openalex.org/F4320338415","display_name":"U.S. Army Medical Research and Development Command","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W27117312","https://openalex.org/W74992319","https://openalex.org/W85233391","https://openalex.org/W122872624","https://openalex.org/W189589452","https://openalex.org/W252642910","https://openalex.org/W1274344746","https://openalex.org/W1492028808","https://openalex.org/W1515226811","https://openalex.org/W1976183578","https://openalex.org/W1982458543","https://openalex.org/W1994078412","https://openalex.org/W2001070274","https://openalex.org/W2006103885","https://openalex.org/W2013827273","https://openalex.org/W2015409036","https://openalex.org/W2021457023","https://openalex.org/W2029303244","https://openalex.org/W2032738293","https://openalex.org/W2050548746","https://openalex.org/W2050580248","https://openalex.org/W2050899871","https://openalex.org/W2052766584","https://openalex.org/W2054425626","https://openalex.org/W2064422560","https://openalex.org/W2069219892","https://openalex.org/W2069987316","https://openalex.org/W2075619062","https://openalex.org/W2076751769","https://openalex.org/W2079122731","https://openalex.org/W2083979433","https://openalex.org/W2086208070","https://openalex.org/W2091087368","https://openalex.org/W2108452932","https://openalex.org/W2117581174","https://openalex.org/W2128564651","https://openalex.org/W2148449018","https://openalex.org/W2151735361","https://openalex.org/W2154101238","https://openalex.org/W2160842550","https://openalex.org/W2218432399","https://openalex.org/W2318523525","https://openalex.org/W2402113779","https://openalex.org/W2404611980","https://openalex.org/W2407328697","https://openalex.org/W2408529386","https://openalex.org/W2410906370","https://openalex.org/W2411873532","https://openalex.org/W2415084464","https://openalex.org/W2415756998","https://openalex.org/W2416488242","https://openalex.org/W2417805593","https://openalex.org/W2419282330","https://openalex.org/W2464125594","https://openalex.org/W2464821644","https://openalex.org/W3022109127","https://openalex.org/W3147894994","https://openalex.org/W4246839970","https://openalex.org/W6601111898","https://openalex.org/W6604966528","https://openalex.org/W6713867676","https://openalex.org/W6716857186","https://openalex.org/W6719912692"],"related_works":["https://openalex.org/W1981435011","https://openalex.org/W1776520887","https://openalex.org/W2027359481","https://openalex.org/W2318523525","https://openalex.org/W2402113779","https://openalex.org/W2117983550","https://openalex.org/W2006103885","https://openalex.org/W1811271163","https://openalex.org/W4236115511","https://openalex.org/W244916542"],"abstract_inverted_index":{"Graft-versus-host":[0],"disease":[1],"(GVHD)":[2],"is":[3,307,329],"a":[4,308,330],"major":[5],"cause":[6],"of":[7,35,43,88,99,162,197,221,246,263,354],"mortality":[8,220],"and":[9,55,61,91,132,149,157,257,291,332],"morbidity":[10],"after":[11],"allogeneic":[12],"bone":[13,27,122],"marrow":[14,54,123],"transplantation,":[15],"but":[16,127],"can":[17,347],"be":[18,348],"avoided":[19],"by":[20],"removing":[21],"T":[22,49],"lymphocytes":[23,328],"from":[24,51],"the":[25,33,41,89,100,138,168,175,187,205,214,222,233,244,250,258,264,273,283,294,342],"donor":[26,53],"marrow.":[28],"However,":[29],"T-cell":[30,305],"depletion":[31,87,98,306],"increases":[32],"risk":[34,245,353],"graft":[36,90,103,198],"rejection.":[37,62],"This":[38],"study":[39],"examined":[40],"use":[42],"CD52":[44],"monoclonal":[45],"antibodies":[46],"to":[47,57,137,311,319,324,335],"eliminate":[48],"cells":[50],"both":[52,59],"recipient":[56,101],"prevent":[58,312],"GVHD":[60,151,164,181,346],"Seventy":[63],"patients":[64,119,135],"receiving":[65],"HLA-identical":[66],"sibling":[67],"transplants":[68],"for":[69,84,95,232],"acute":[70,163],"myelogenous":[71],"leukemia":[72,247],"(AML)":[73],"in":[74,85,96,130,167,174,186,204,213,243,296,340,345],"first":[75],"remission":[76],"were":[77,111],"studied.":[78],"An":[79],"IgM":[80],"(CAMPATH-1M)":[81],"was":[82,108,165,182,210,229,240,270,285,293],"used":[83],"vitro":[86],"an":[92,351],"IgG":[93],"(CAMPATH-1G)":[94],"vivo":[97],"before":[102],"infusion.":[104],"No":[105],"posttransplant":[106],"immunosuppression":[107],"given.":[109],"Results":[110],"compared":[112,171],"with":[113,125,153,172],"two":[114],"control":[115],"groups:":[116],"(1)":[117],"50":[118],"who":[120,145],"received":[121,146],"depleted":[124],"CAMPATH-1M,":[126],"no":[128],"CAMPATH-1G":[129,323],"vivo;":[131],"(2)":[133],"459":[134],"reported":[136],"International":[139],"Bone":[140],"Marrow":[141],"Transplant":[142],"Registry":[143],"(IBMTR)":[144],"nondepleted":[147],"grafts":[148],"conventional":[150],"prophylaxis":[152],"cyclosporin":[154],"A":[155],"(CyA)":[156],"methotrexate":[158],"(MTX).":[159],"The":[160,195],"incidence":[161],"4%":[166],"treatment":[169,188,215,223,251,265],"group":[170,177,189,208,216,224,235,252,260,266,275],"35%":[173],"CyA/MTX":[176,234,259,274],"(P":[178],"<.001).":[179,194],"Chronic":[180],"also":[183],"exceptionally":[184],"low":[185],"(3%":[190],"v":[191,277,289,300],"36%;":[192],"P":[193,237],"problem":[196],"rejection,":[199],"which":[200],"had":[201],"been":[202],"frequent":[203],"historic":[206],"CAMPATH-1M":[207],"(31%),":[209],"largely":[211],"overcome":[212],"(6%).":[217],"Thus,":[218],"transplant-related":[219],"(15%":[225],"at":[226,254,267,280],"5":[227,255,281],"years)":[228,256],"lower":[230],"than":[231,272],"(26%;":[236],"=.04).":[238],"There":[239],"little":[241],"difference":[242,284,295],"relapse":[248],"between":[249],"(30%":[253],"(29%).":[261],"Survival":[262],"6":[268],"months":[269],"better":[271],"(92%":[276],"78%),":[278],"although":[279],"years":[282],"not":[286],"significant":[287],"(62%":[288],"58%)":[290],"neither":[292],"leukemia-free":[297],"survival":[298],"(60%":[299],"52%).":[301],"We":[302],"conclude":[303],"that":[304,315],"useful":[309],"strategy":[310],"GVHD,":[313],"provided":[314],"measures":[316],"are":[317],"taken":[318],"ensure":[320],"engraftment.":[321],"Using":[322],"deplete":[325],"residual":[326],"host":[327],"simple":[331],"practical":[333],"method":[334],"do":[336],"this.":[337],"At":[338],"least":[339],"AML,":[341],"beneficial":[343],"reduction":[344],"achieved":[349],"without":[350],"increased":[352],"relapse.":[355]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
