{"id":"https://openalex.org/W962749490","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.622.10","title":"Development of dietary methyl score using plasma homocysteine level in the large two US cohort study","display_name":"Development of dietary methyl score using plasma homocysteine level in the large two US cohort study","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W962749490","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.622.10","mag":"962749490"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.622.10","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.622.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.622.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018709897","display_name":"Seungyoun Jung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seungyoun Jung","raw_affiliation_strings":["Department of Medicine, Channing Division of Network Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Channing Division of Network Medicine, Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018055906","display_name":"Youjin Je","orcid":"https://orcid.org/0000-0002-2099-4204","observed_orcids":["https://orcid.org/0000-0002-2099-4204","https://orcid.org/0000-0001-8714-2690"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youjin Je","raw_affiliation_strings":["Kyunghee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyunghee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038373228","display_name":"Edward L. Giovannucci","orcid":"https://orcid.org/0000-0002-6123-0219","observed_orcids":["https://orcid.org/0000-0002-6123-0219","https://orcid.org/0009-0003-9117-569X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Giovannucci","raw_affiliation_strings":["Department of Medicine, Channing Division of Network Medicine, Boston, MA","Nutrition, Harvard School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Channing Division of Network Medicine, Boston, MA","institution_ids":[]},{"raw_affiliation_string":"Nutrition, Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083991449","display_name":"Walter Churchill Willett","orcid":"https://orcid.org/0000-0003-1458-7597","observed_orcids":["https://orcid.org/0000-0003-1458-7597"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter C. Willet","raw_affiliation_strings":["Department of Medicine, Channing Division of Network Medicine, Boston, MA","Nutrition, Harvard School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Channing Division of Network Medicine, Boston, MA","institution_ids":[]},{"raw_affiliation_string":"Nutrition, Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089191285","display_name":"BERNARD A. ROSNER","orcid":"https://orcid.org/0000-0001-6907-0056","observed_orcids":["https://orcid.org/0000-0001-6907-0056"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard Rosner","raw_affiliation_strings":["Biostatistics, Harvard School of Public Health, Boston, MA","Department of Medicine, Channing Division of Network Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Channing Division of Network Medicine, Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076818447","display_name":"Shuji Ogino","orcid":"https://orcid.org/0000-0002-3909-2323","observed_orcids":["https://orcid.org/0000-0002-3909-2323"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuji Ogino","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA","Epidemiology, Harvard School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Epidemiology, Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074009555","display_name":"Eunyoung Cho","orcid":"https://orcid.org/0000-0001-6594-2582","observed_orcids":["https://orcid.org/0000-0001-6594-2582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eunyoung Cho","raw_affiliation_strings":["Department of Medicine, Channing Division of Network Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Channing Division of Network Medicine, Boston, MA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04853815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-homocysteine","display_name":"plasma homocysteine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.8119999766349792},{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.925000011920929},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.7139999866485596},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.8989999890327454},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.8880000114440918},{"id":"https://openalex.org/keywords/betaine","display_name":"betaine","score":0.8809999823570251},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.8309999704360962},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.9520000219345093},{"id":"https://openalex.org/keywords/nutritional-biomarkers","display_name":"dietary biomarkers","score":0.492000013589859},{"id":"https://openalex.org/keywords/nurses-health-study","display_name":"Nurses' Health Study","score":0.9340000152587891},{"id":"https://openalex.org/keywords/health-professionals-follow-up-study","display_name":"Health Professionals Follow-up Study","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.7783926129341125},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.722159743309021},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.6920833587646484},{"id":"https://openalex.org/C3017560507","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Plasma homocysteine","level":3,"score":0.6184267401695251},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5256732106208801},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.49982237815856934},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.47737404704093933},{"id":"https://openalex.org/C142796444","wikidata":"https://www.wikidata.org/wiki/Q181394","display_name":"Nutrient","level":2,"score":0.4759937524795532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43969473242759705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38254866003990173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3321754038333893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3182564973831177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30737245082855225},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.12605643272399902},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12426653504371643},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08050006628036499},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.05608382821083069}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.622.10","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.622.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.622.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.5666999816894531,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018628567","https://openalex.org/W6981150301","https://openalex.org/W2121349585","https://openalex.org/W2012774141","https://openalex.org/W2117312367","https://openalex.org/W4255079029","https://openalex.org/W2885119316","https://openalex.org/W2325064466","https://openalex.org/W2605222754","https://openalex.org/W1963662956"],"abstract_inverted_index":{"Backgrounds":[0],"One\u2010carbon":[1],"metabolism,":[2],"crucial":[3],"in":[4,46,99,121,138,199,234,242],"DNA":[5],"synthesis":[6],"and":[7,51,64,97,160,166,171],"genomic":[8],"stability,":[9],"is":[10,31],"a":[11],"metabolic":[12],"pathway":[13,30],"where":[14],"nutrients":[15,27,84,129],"are":[16],"networked":[17],"interdependently.":[18],"The":[19,108,126,232],"development":[20],"of":[21,36,110,132,135,164,187,218],"comprehensive":[22],"score":[23,71,114,177,182,226],"integrating":[24],"the":[25,29,47,52,61,65,78,100,104,111,122,133,139,150,176,185,188,196,200,219,235,243],"interconnected":[26],"within":[28],"necessary.":[32],"Methods":[33],"A":[34],"total":[35,42],"3,283":[37],"participants":[38],"with":[39,77,115,195],"measured":[40],"plasma":[41,73,116,136,197,210,228],"homocysteine":[43],"(tHCY)":[44],"levels":[45,118],"Nurses\u2019":[48],"Health":[49,53],"Study":[50,56],"Professionals":[54],"Follow\u2010up":[55],"were":[57,75,149,169,172],"randomly":[58],"divided":[59],"into":[60],"training":[62,101],"(n=2,626)":[63],"testing":[66,123,201],"subset":[67],"(n=657).":[68],"Dietary":[69,224],"methyl":[70,113,181,221,225,245],"predicting":[72],"tHCY":[74,117,137,198,211,229],"derived":[76,183],"known":[79,127],"one":[80],"carbon":[81],"metabolism":[82,237],"related":[83],"(alcohol,":[85],"folate,":[86,155],"vitamin":[87,89,91,93,158,167],"B2,":[88],"B12,":[90,94],"B6,":[92,159],"betaine,":[95,157],"choline,":[96,165],"methionine)":[98],"set":[102,202],"using":[103],"multivariate":[105,140,189],"linear":[106],"regression.":[107],"correlation":[109,204],"dietary":[112,180,220,244],"was":[119,192],"assessed":[120],"set.":[124],"Results":[125],"one\u2010carbon":[128,236],"explained":[130],"29%":[131],"variation":[134],"prediction":[141,190],"model":[142,191],"(model":[143],"r":[144,205],"2":[145],"=":[146,208],".29).Vitamin":[147],"B2":[148],"strongest":[151],"predictor,":[152],"followed":[153],"by":[154],"alcohol,":[156],"methionine":[161],"(P<.05).":[162],"Intake":[163],"B12":[168],"non\u2010significant":[170],"taken":[173],"out":[174],"from":[175,184],"calculation.":[178],"Our":[179],"coefficient":[186],"positively":[193],"correlated":[194],"(Pearson":[203],"=0.28,":[206],"P":[207],"<.001;":[209],"range=":[212],"10\u201314":[213],"umol/L":[214],"comparing":[215],"extreme":[216],"deciles":[217],"score).":[222],"Conclusions":[223],"predicted":[227],"level":[230],"significantly.":[231],"complexity":[233],"may":[238],"be":[239],"better":[240],"reflected":[241],"score.":[246]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
