{"id":"https://openalex.org/W96151597","doi":null,"title":"Pharmacological Restriction of Innate Immunity for the Replication and Detection of Human Viral Pathogens","display_name":"Pharmacological Restriction of Innate Immunity for the Replication and Detection of Human Viral Pathogens","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W96151597","mag":"96151597"},"language":"en","primary_location":{"id":"pmh:oai:kb.osu.edu:1811/45494","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/45494","pdf_url":"http://hdl.handle.net/1811/45494","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1811/45494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053393250","display_name":"Dandrich Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dandrich Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053393250"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.05000000074505806,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":1.0},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9620000123977661},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6430000066757202},{"id":"https://openalex.org/keywords/norovirus","display_name":"norovirus","score":0.7200000286102295},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/purine-analogs","display_name":"purine analogues","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ribonucleotide-reductase-inhibition","display_name":"ribonucleotide reductase inhibition","score":0.796999990940094},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7735614776611328},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.6476513147354126},{"id":"https://openalex.org/C137993225","wikidata":"https://www.wikidata.org/wiki/Q6058723","display_name":"Intrinsic immunity","level":4,"score":0.5762432217597961},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5725351572036743},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5629950761795044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5235780477523804},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4980278015136719},{"id":"https://openalex.org/C2994541485","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral infection","level":3,"score":0.49588117003440857},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39979997277259827},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.23609253764152527},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21842947602272034}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kb.osu.edu:1811/45494","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/45494","pdf_url":"http://hdl.handle.net/1811/45494","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:96151597","doi":null,"is_oa":false,"landing_page_url":"http://kb.osu.edu/dspace/handle/1811/45494","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kb.osu.edu:1811/45494","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/45494","pdf_url":"http://hdl.handle.net/1811/45494","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W96151597.pdf","grobid_xml":"https://content.openalex.org/works/W96151597.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W65919465","https://openalex.org/W1524269393","https://openalex.org/W1969430178","https://openalex.org/W1986589902","https://openalex.org/W2000871561","https://openalex.org/W2007608885","https://openalex.org/W2009392385","https://openalex.org/W2028254759","https://openalex.org/W2028575270","https://openalex.org/W2029275361","https://openalex.org/W2032691915","https://openalex.org/W2043064608","https://openalex.org/W2080347641","https://openalex.org/W2096109794","https://openalex.org/W2115072991","https://openalex.org/W2122746816","https://openalex.org/W2127096990","https://openalex.org/W2130747214","https://openalex.org/W2138081830","https://openalex.org/W2148985310","https://openalex.org/W2153342952","https://openalex.org/W2157339124","https://openalex.org/W2158026372","https://openalex.org/W2161208630"],"related_works":["https://openalex.org/W3157411135","https://openalex.org/W2037398775","https://openalex.org/W2927139959","https://openalex.org/W2391132513","https://openalex.org/W2013763814","https://openalex.org/W2070538125","https://openalex.org/W2093240993","https://openalex.org/W2166014786","https://openalex.org/W1971245246","https://openalex.org/W1514942184"],"abstract_inverted_index":{"The":[0,95,203,238],"focus":[1],"of":[2,11,29,67,85,135],"this":[3],"study":[4,71,239],"is":[5,23,34],"to":[6,19,99,104,130,141,161,244],"explore":[7],"the":[8,12,27,65,83,183,221,246],"immunosuppressive":[9],"effect":[10],"chemotherapy":[13],"drug":[14,153,188,227],"fludarabine":[15,55,74,164,207,247],"and":[16,38,47,58,81,117,137,156,195,229,234],"its":[17],"application":[18],"viral":[20,77,119,167,196,224],"cultivation.":[21],"Fludarabine":[22],"mainly":[24],"used":[25,129,160,181],"in":[26,79,223],"treatment":[28,165,189,248],"chronic":[30],"lymphocytic":[31],"leukemia.":[32],"It":[33],"a":[35,101,172],"purine":[36],"analog":[37],"inhibits":[39],"DNA":[40,48],"synthesis":[41],"by":[42],"interfering":[43],"with":[44,108,218],"ribonucleotide":[45],"reductase":[46],"polymerase.":[49],"Some":[50],"studies":[51],"also":[52,240],"show":[53],"that":[54,88,143,206],"induces":[56],"severe":[57],"prolonged":[59],"immunosuppresion;":[60],"such":[61,92],"effects":[62],"often":[63],"increase":[64],"risk":[66],"opportunistic":[68],"infections.":[69,120],"This":[70],"explores":[72],"whether":[73,163],"may":[75],"enhance":[76,118],"infection":[78],"vitro":[80],"aid":[82],"process":[84],"cultivating":[86],"viruses":[87],"are":[89],"previously":[90],"uncultivable,":[91],"as":[93],"Norovirus.":[94],"immediate":[96],"goal":[97],"was":[98,180],"develop":[100],"standardized":[102],"procedure":[103],"treat":[105],"cell":[106,115,147],"lines":[107],"fludarabine,":[109,136],"suppress":[110],"innate":[111],"immunity":[112],"while":[113],"retaining":[114],"viability,":[116],"Carcinomic":[121],"human":[122],"alveolar":[123],"basal":[124],"epithelial":[125],"cells":[126,209,215,231],"(A549)":[127],"were":[128,159,199,232],"first":[131],"test":[132],"for":[133,182],"cytotoxicity":[134,212],"an":[138,151],"optimal":[139],"concentration":[140],"use":[142],"would":[144],"still":[145],"retain":[146],"viability.":[148],"After":[149],"obtaining":[150],"optimum":[152],"concentration,":[154],"qualitative":[155],"quantitative":[157],"methods":[158,243],"determine":[162],"enhances":[166],"infectivity;":[168],"bovine":[169],"enterovirus-1":[170],"(BEV-1),":[171],"single":[173],"stranded":[174],"RNA":[175],"virus":[176],"having":[177],"positive":[178],"polarity,":[179],"test.":[184],"Treatment":[185],"exposure":[186],"time,":[187],"method":[190],"(pre-treatment":[191],"or":[192],"continuous":[193],"exposure),":[194],"samples":[197],"concentrations":[198],"all":[200],"testable":[201],"variables.":[202],"results":[204],"indicated":[205],"treated":[208,228],"exhibited":[210],"greater":[211],"than":[213],"non-treated":[214,230],"when":[216],"infected":[217],"BEV-1;":[219],"however,":[220],"difference":[222],"yields":[225],"between":[226],"inconclusive":[233],"required":[235],"further":[236],"experimentations.":[237],"discusses":[241],"potential":[242],"improve":[245],"protocol.":[249]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}