{"id":"https://openalex.org/W961479641","doi":null,"title":"An Examination of Candida albicans Mannosylation Mutants and their CW Structures","display_name":"An Examination of Candida albicans Mannosylation Mutants and their CW Structures","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W961479641","mag":"961479641"},"language":"en","primary_location":{"id":"pmh:oai:commons.library.stonybrook.edu:stony-brook-theses-and-dissertations-collection-3795","doi":null,"is_oa":false,"landing_page_url":"https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/2796","pdf_url":null,"source":{"id":"https://openalex.org/S4377196674","display_name":"Academic Commons (Stony Brook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59553526","host_organization_name":"Stony Brook University","host_organization_lineage":["https://openalex.org/I59553526"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019229732","display_name":"Frank A. Mindlin","orcid":"https://orcid.org/0000-0003-0417-7033","observed_orcids":["https://orcid.org/0000-0003-0417-7033"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mindlin, Frank August","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019229732"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.23690000176429749,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0738999992609024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/cell-wall","display_name":"cell wall","score":0.5659999847412109},{"id":"https://openalex.org/keywords/immune-recognition","display_name":"immune recognition","score":0.6079999804496765},{"id":"https://openalex.org/keywords/macrophage-recognition","display_name":"macrophage recognition","score":0.9649999737739563},{"id":"https://openalex.org/keywords/fungal-virulence","display_name":"fungal virulence","score":0.5009999871253967},{"id":"https://openalex.org/keywords/antifungal-drug-targets","display_name":"antifungal drug targets","score":0.8730000257492065},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7656800746917725},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5036582350730896},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4935213327407837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3895755708217621},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.199865460395813},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12025517225265503}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:commons.library.stonybrook.edu:stony-brook-theses-and-dissertations-collection-3795","doi":null,"is_oa":false,"landing_page_url":"https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/2796","pdf_url":null,"source":{"id":"https://openalex.org/S4377196674","display_name":"Academic Commons (Stony Brook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59553526","host_organization_name":"Stony Brook University","host_organization_lineage":["https://openalex.org/I59553526"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2345739108","https://openalex.org/W2047067218","https://openalex.org/W2086193922","https://openalex.org/W2039040668","https://openalex.org/W4220987600","https://openalex.org/W2127458887","https://openalex.org/W2171861423","https://openalex.org/W2080464858","https://openalex.org/W1986407125","https://openalex.org/W2018337931"],"abstract_inverted_index":{"Candida":[0,198],"albicans":[1,137,290,305],"is":[2,59,100],"the":[3,26,29,52,56,83,94,126,156,161,164,177,215,248,266,277],"most":[4],"important":[5],"human":[6],"pathogenic":[7],"fungus.":[8],"Due":[9],"to":[10,24,51,79,109,142,194],"rising":[11],"rates":[12],"of":[13,28,45,55,61,82,93,102,128,163,176,214,240,260,276,284,302,316],"infection":[14],"and":[15,150,202,221,295],"limited":[16],"treatment":[17],"options,":[18],"it":[19],"has":[20],"become":[21],"increasingly":[22],"vital":[23],"identify":[25],"structures":[27,85],"cell":[30,132],"wall":[31],"(CW)":[32],"that":[33,112,139,159,171,179,233,252,268],"can":[34],"serve":[35],"as":[36],"ligands":[37,111],"for":[38,87,208,281,293],"anti-fungal":[39,319],"drug":[40],"recognition.":[41,89],"Recently,":[42],"a":[43,273],"number":[44],"studies":[46,228],"have":[47,75,106,180,190],"focused":[48],"their":[49],"attention":[50],"outer":[53,97,166,216],"portion":[54],"CW,":[57],"which":[58,99],"comprised":[60,101],"glycoproteins":[62],"modified":[63],"with":[64],"asparagine":[65],"(N)-linked":[66],"or":[67,69],"serine":[68],"threonine":[70],"(O)-linked":[71],"mannan.":[72],"Current":[73],"models":[74],"shown":[76],"N-linked":[77,95,237,278],"mannan":[78,96,129,165,279],"be":[80,115],"one":[81],"key":[84],"responsible":[86,207],"immune-cell":[88],"Mutations":[90],"in":[91,130,155,183,197,218,229,255,309],"construction":[92],"chain,":[98],"~200":[103],"mannose":[104,211,243],"units,":[105,244],"been":[107],"hypothesized":[108],"lack":[110,143],"would":[113],"otherwise":[114],"recognized":[116],"by":[117,134],"macrophages":[118],"[38].":[119],"Here":[120],"I":[121,189],"performed":[122],"experiments":[123],"toward":[124],"testing":[125],"role":[127],"immune":[131,282],"recognition,":[133],"constructing":[135],"C.":[136,285,289,304],"mutants":[138,152,235,270],"are":[140,153,186,205,253,271],"predicted":[141],"these":[144,269,303],"structures.":[145],"The":[146,200],"S.":[147,219,230],"cerevisiae":[148,220,231,262],"mnn10":[149,234],"mnn11":[151],"defective":[154],"\u03b1":[157,209],"-1,6-mannosyltransferases":[158],"build":[160],"backbone":[162],"chain.":[167],"Furthermore,":[168],"recent":[169],"literature":[170],"describes":[172],"various":[173],"other":[174,223],"components":[175,275],"CW":[178],"potential":[181],"roles":[182],"macrophage":[184],"recognition":[185,283],"also":[187,191],"studied.":[188],"constructed":[192,288],"plasmids":[193],"knockout":[195],"MNN11":[196,203],"albicans.":[199],"MNN10":[201,294],"genes":[204],"primarily":[206],"-1,6-linked":[210],"polymerizing":[212],"activity":[213],"chain":[217],"several":[222],"yeast":[224],"species":[225],"[4,5].":[226],"Earlier":[227],"concluded":[232],"contain":[236],"oligosaccharide":[238],"chains":[239],"approximately":[241],"6-16":[242],"comparatively":[245],"shorter":[246],"than":[247],"average":[249],"50":[250],"units":[251],"found":[254],"wild":[256],"type":[257],"(WT)":[258],"strains":[259,291,308],"Saccharomyces":[261],"[5].":[263],"To":[264],"test":[265],"model":[267],"lacking":[272],"critical":[274],"ligand":[280],"albicans,":[286],"we":[287],"deleted":[292],"its":[296],"homologous":[297],"gene":[298],"MNN11.":[299],"Future":[300],"analyses":[301],"mannosyltransferase":[306],"mutant":[307],"mice":[310],"may":[311],"provide":[312],"insight":[313],"into":[314],"development":[315],"more":[317],"specific":[318],"therapies.":[320],"|":[321],"52":[322],"pages":[323]},"counts_by_year":[],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2016-06-24T00:00:00"}