{"id":"https://openalex.org/W96055652","doi":"https://doi.org/10.1007/978-1-61737-973-4_2","title":"Pluripotent Stem Cells from the Postnatal Testis: Unlocking the Potential of Spermatogonial Stem Cells","display_name":"Pluripotent Stem Cells from the Postnatal Testis: Unlocking the Potential of Spermatogonial Stem Cells","publication_year":2010,"publication_date":"2010-11-15","ids":{"openalex":"https://openalex.org/W96055652","doi":"https://doi.org/10.1007/978-1-61737-973-4_2","mag":"96055652"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-61737-973-4_2","doi":"https://doi.org/10.1007/978-1-61737-973-4_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-61737-973-4_2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Male Germline Stem Cells: Developmental and Regenerative Potential","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W627391332","display_name":"Male Germline Stem Cells: Developmental and Regenerative Potential"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067846615","display_name":"Marco Seandel","orcid":"https://orcid.org/0000-0003-1578-834X","observed_orcids":["https://orcid.org/0000-0003-1578-834X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marco Seandel","raw_affiliation_strings":["Department of Surgery, Weill Medical College of Cornell University, 1300 York Avenue, Room LC-703, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Medical College of Cornell University, 1300 York Avenue, Room LC-703, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026483985","display_name":"Ilaria Falciatori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilaria Falciatori","raw_affiliation_strings":["Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090799132","display_name":"Shahin Rafii","orcid":"https://orcid.org/0000-0001-5605-1067","observed_orcids":["https://orcid.org/0000-0001-5605-1067"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shahin Rafii","raw_affiliation_strings":["Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, Room A-863, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, Room A-863, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067846615","https://openalex.org/A5090799132"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":0.7758,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.73153779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"25","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermatogonial-stem-cells","display_name":"spermatogonial stem cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/postnatal-testis","display_name":"postnatal testis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8610000014305115},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/germ-cells","display_name":"germ cells","score":0.6209999918937683},{"id":"https://openalex.org/keywords/epigenetic-factors","display_name":"epigenetic factors","score":0.953000009059906},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.7900000214576721},{"id":"https://openalex.org/keywords/germ-cell-differentiation","display_name":"germ cell differentiation","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8082093000411987},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7694852948188782},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7491655349731445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6938527226448059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6730302572250366},{"id":"https://openalex.org/C23416140","wikidata":"https://www.wikidata.org/wiki/Q6335239","display_name":"KOSR","level":5,"score":0.6007887125015259},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.508274495601654},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4828525185585022},{"id":"https://openalex.org/C18155467","wikidata":"https://www.wikidata.org/wiki/Q660498","display_name":"Germ layer","level":5,"score":0.43010902404785156},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4195478558540344},{"id":"https://openalex.org/C27390768","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Cell potency","level":5,"score":0.41724899411201477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23350384831428528},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17289304733276367}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-61737-973-4_2","doi":"https://doi.org/10.1007/978-1-61737-973-4_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-61737-973-4_2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Male Germline Stem Cells: Developmental and Regenerative Potential","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W1486455950","https://openalex.org/W1558096440","https://openalex.org/W1565499521","https://openalex.org/W1608762409","https://openalex.org/W1918200576","https://openalex.org/W1932855363","https://openalex.org/W1957763880","https://openalex.org/W1965813621","https://openalex.org/W1966504370","https://openalex.org/W1968931043","https://openalex.org/W1970288444","https://openalex.org/W1970640260","https://openalex.org/W1974652594","https://openalex.org/W1977401169","https://openalex.org/W1980970119","https://openalex.org/W1981088384","https://openalex.org/W1985140771","https://openalex.org/W1987163411","https://openalex.org/W1987807276","https://openalex.org/W1991037959","https://openalex.org/W1993624225","https://openalex.org/W1997444723","https://openalex.org/W2001530424","https://openalex.org/W2002179012","https://openalex.org/W2002747495","https://openalex.org/W2006168456","https://openalex.org/W2006264555","https://openalex.org/W2008250496","https://openalex.org/W2009498922","https://openalex.org/W2011090802","https://openalex.org/W2013518855","https://openalex.org/W2016789158","https://openalex.org/W2018304597","https://openalex.org/W2023844789","https://openalex.org/W2026399748","https://openalex.org/W2027011084","https://openalex.org/W2032570745","https://openalex.org/W2032711435","https://openalex.org/W2032975011","https://openalex.org/W2033042516","https://openalex.org/W2037055772","https://openalex.org/W2037979286","https://openalex.org/W2040605613","https://openalex.org/W2045887697","https://openalex.org/W2045899482","https://openalex.org/W2049153989","https://openalex.org/W2050518767","https://openalex.org/W2050689355","https://openalex.org/W2052490309","https://openalex.org/W2053911973","https://openalex.org/W2054521968","https://openalex.org/W2054939637","https://openalex.org/W2059033739","https://openalex.org/W2059434082","https://openalex.org/W2063897963","https://openalex.org/W2069029882","https://openalex.org/W2071617308","https://openalex.org/W2072218174","https://openalex.org/W2072230758","https://openalex.org/W2073685126","https://openalex.org/W2073738799","https://openalex.org/W2082909767","https://openalex.org/W2084562248","https://openalex.org/W2086470708","https://openalex.org/W2088612857","https://openalex.org/W2092463855","https://openalex.org/W2097613600","https://openalex.org/W2100012145","https://openalex.org/W2101565743","https://openalex.org/W2105425843","https://openalex.org/W2107575419","https://openalex.org/W2110804359","https://openalex.org/W2113933705","https://openalex.org/W2123646177","https://openalex.org/W2125331453","https://openalex.org/W2125987139","https://openalex.org/W2128786355","https://openalex.org/W2131238404","https://openalex.org/W2133990340","https://openalex.org/W2135373970","https://openalex.org/W2139789628","https://openalex.org/W2142046859","https://openalex.org/W2144134929","https://openalex.org/W2145172444","https://openalex.org/W2148679920","https://openalex.org/W2150163104","https://openalex.org/W2151499107","https://openalex.org/W2151981492","https://openalex.org/W2152483372","https://openalex.org/W2162477954","https://openalex.org/W2165892496","https://openalex.org/W2169529166","https://openalex.org/W2171200951","https://openalex.org/W2419552819","https://openalex.org/W3150683859","https://openalex.org/W4211118035"],"related_works":["https://openalex.org/W2078618198","https://openalex.org/W2128786355","https://openalex.org/W2980715646","https://openalex.org/W2086470708","https://openalex.org/W65037328","https://openalex.org/W2146959635","https://openalex.org/W7135982396","https://openalex.org/W2263049503","https://openalex.org/W2033042516","https://openalex.org/W1976226574"],"abstract_inverted_index":{"While":[0],"embryonic":[1],"stem":[2,32,112,137],"(ES)":[3],"cells":[4,24,33,64,85,113,133],"are":[5,91],"well":[6],"known":[7],"to":[8,11,65,128],"give":[9],"rise":[10],"tissues":[12,90],"comprising":[13],"all":[14],"three":[15],"germ":[16,63],"layers,":[17],"only":[18],"recently":[19],"was":[20],"it":[21],"shown":[22],"that":[23],"from":[25,41,86],"the":[26,49,57,81,96,101,115],"postnatal":[27,62],"testis":[28],"could":[29],"produce":[30],"embryonic-like":[31],"in":[34,39,126],"culture.":[35],"The":[36,76,107],"latter,":[37],"arising":[38],"vitro":[40],"spermatogonia,":[42],"can":[43],"undertake":[44],"most,":[45],"if":[46],"not":[47],"all,":[48],"functions":[50],"of":[51,70,83,100,104,110,117],"ES":[52,132],"cells.":[53,106,139],"This":[54],"chapter":[55],"explores":[56],"potential":[58],"predisposing":[59],"factors":[60],"for":[61,114,120],"become":[66],"pluripotent,":[67],"including":[68],"expression":[69],"pluripotency-associated":[71],"genes":[72],"and":[73,88,119,134],"epigenetic":[74],"factors.":[75],"major":[77],"published":[78],"studies":[79],"describing":[80],"production":[82],"ES-like":[84,105],"mice":[87],"human":[89],"reviewed.":[92],"Finally,":[93],"we":[94],"assess":[95],"data":[97],"demonstrating":[98],"functionality":[99],"differentiated":[102],"derivatives":[103],"possible":[108],"uses":[109],"testis-derived":[111],"study":[116],"pluripotency":[118],"regenerative":[121],"applications":[122],"is":[123],"also":[124],"discussed":[125],"comparison":[127],"other":[129],"approaches":[130],"using":[131],"induced":[135],"pluripotent":[136],"(ips)":[138]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}