{"id":"https://openalex.org/W96045771","doi":null,"title":"A second international cooperative investigation into tioacetazone side effects.","display_name":"A second international cooperative investigation into tioacetazone side effects.","publication_year":1972,"publication_date":"1972-01-01","ids":{"openalex":"https://openalex.org/W96045771","mag":"96045771","pmid":"https://pubmed.ncbi.nlm.nih.gov/4118761","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2480900"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1446331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2480900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2480900","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A B Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062598432","display_name":"Andrew Nunn","orcid":"https://orcid.org/0000-0002-9158-4595","observed_orcids":["https://orcid.org/0000-0002-9158-4595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Nunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111903375","display_name":"D. K. Robinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D K Robinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110067783","display_name":"Wallace Fox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Fox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037803286","display_name":"P. R. Somasundaram","orcid":"https://orcid.org/0009-0009-4512-2339","observed_orcids":["https://orcid.org/0009-0009-4512-2339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P R Somasundaram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070128947","display_name":"Ruth Tall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Tall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5109,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.90809578,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"47","issue":"2","first_page":"211","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thioacetazone","display_name":"thioacetazone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.5149999856948853},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cross-national-comparison","display_name":"cross-national comparison","score":0.46000000834465027},{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cutaneous-adverse-effects","display_name":"cutaneous adverse events","score":0.8069999814033508},{"id":"https://openalex.org/keywords/patient-supervision","display_name":"patient supervision","score":0.7440000176429749},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.7870000004768372},{"id":"https://openalex.org/keywords/streptomycin","display_name":"streptomycin","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6604502201080322},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.5639680624008179},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.44838523864746094},{"id":"https://openalex.org/C2779545769","wikidata":"https://www.wikidata.org/wiki/Q5135364","display_name":"Closeness","level":2,"score":0.42415809631347656},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.4183940291404724},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000352","descriptor_name":"Africa, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001208","descriptor_name":"Asia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003604","descriptor_name":"Czechoslovakia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005843","descriptor_name":"Geography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007391","descriptor_name":"International Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013828","descriptor_name":"Thioacetazone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014300","descriptor_name":"Trinidad and Tobago","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D044469","descriptor_name":"Racial Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:1446331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2480900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2480900","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2480900","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull World Health Organ","raw_type":"Text"},{"id":"pmid:4118761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4118761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1514184","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1514184/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bull World Health Organ , 47 (2) pp. 211-227. (1972)","raw_type":"Article"},{"id":"mag:96045771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4118761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1446331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2480900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W336806041","https://openalex.org/W1971984854","https://openalex.org/W2055835889","https://openalex.org/W2079204086","https://openalex.org/W2083388815","https://openalex.org/W2411991083"],"related_works":["https://openalex.org/W2013511100","https://openalex.org/W312142829","https://openalex.org/W2083388815","https://openalex.org/W1984882558","https://openalex.org/W7098473909","https://openalex.org/W4231255580","https://openalex.org/W2463812886","https://openalex.org/W2027070734","https://openalex.org/W2465444396","https://openalex.org/W2410600991"],"abstract_inverted_index":{"As":[0],"part":[1],"of":[2,12,18,25,31,46,57,72,87,91,174,187,189,196,207],"a":[3,69,95,120],"large-scale":[4],"international":[5],"cooperative":[6],"investigation":[7],"into":[8],"the":[9,16,26,29,42,47,65,79,84,101,106,112,124,151,169,172,185,192,204],"side":[10,32,88,158,175,197],"effects":[11,33,89,159,176],"thioacetazone-containing":[13,108,178],"regimens":[14,109,179],"in":[15,28,41,64,83,149,160,164,171,184,191,200],"treatment":[17,73],"tuberculosis,":[19],"an":[20,146],"evaluation":[21],"has":[22],"been":[23],"made":[24],"variation":[27,77,102,183],"frequency":[30,86,173],"between":[34,38,78,153],"different":[35,39,58,132],"countries":[36,55,80],"and":[37,45,81,90,110,129,162,194,199],"centres":[40,82],"same":[43,66],"country":[44],"likely":[48],"reasons":[49],"for":[50,105,111,123,156],"this":[51],"variation.":[52],"In":[53,126],"3":[54],"patients":[56],"racial":[59,133],"origin":[60],"were":[61,135],"under":[62,136],"observation":[63],"hospital.":[67],"Over":[68],"12-week":[70],"period":[71],"there":[74,138],"was":[75,139,145],"considerable":[76],"overall":[85],"those":[92],"leading":[93],"to":[94,177,212],"major":[96],"departure":[97],"from":[98,182],"prescribed":[99],"treatment,":[100,137],"being":[103],"similar":[104],"two":[107],"streptomycin":[113],"plus":[114],"isoniazid":[115],"control":[116],"regimen,":[117],"though":[118],"at":[119],"lower":[121],"level":[122],"latter.":[125],"Malaysia,":[127],"Singapore,":[128],"Trinidad,":[130],"where":[131],"groups":[134],"no":[140],"clear":[141],"indication":[142],"that":[143,168],"race":[144],"important":[147],"factor":[148],"explaining":[150],"differences":[152,170],"countries,":[154],"except":[155],"cutaneous":[157],"Trinidad":[161],"possibly":[163],"Malaysia.It":[165],"is":[166],"concluded":[167],"probably":[180],"result":[181],"closeness":[186],"supervision":[188],"patients,":[190],"recording":[193],"interpretation":[195],"effects,":[198],"environmental":[201],"factors":[202],"including":[203],"previous":[205],"use":[206],"other":[208],"medicaments":[209],"or":[210],"exposure":[211],"sensitizing":[213],"substances.":[214]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}