{"id":"https://openalex.org/W9594690","doi":null,"title":"Inhibition of tau hyperphosphorylation and beta amyloid production in rat brain by oral administration of atorvastatin.","display_name":"Inhibition of tau hyperphosphorylation and beta amyloid production in rat brain by oral administration of atorvastatin.","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W9594690","mag":"9594690","pmid":"https://pubmed.ncbi.nlm.nih.gov/20819569"},"language":"en","primary_location":{"id":"pmid:20819569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20819569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108270842","display_name":"LU Fen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fen Lu","raw_affiliation_strings":["Department of Neurology, People's Hospital of Henan Province, Zhengzhou, Henan 450003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, People's Hospital of Henan Province, Zhengzhou, Henan 450003, China","institution_ids":["https://openalex.org/I4210133534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342497","display_name":"Xu Li","orcid":"https://orcid.org/0000-0003-3069-2071","observed_orcids":["https://orcid.org/0000-0003-3069-2071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062955490","display_name":"Ai-qin Suo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ai-Qin Suo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100715200","display_name":"Jiewen Zhang","orcid":"https://orcid.org/0000-0001-6784-6658","observed_orcids":["https://orcid.org/0000-0001-6784-6658","https://orcid.org/0000-0002-2362-6300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie-Wen Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5653,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.57169678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"123","issue":"14","first_page":"1864","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9620000123977661},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.9879999756813049},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.781000018119812},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.751833438873291},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.722564697265625},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.7124475240707397},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6469106078147888},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5480721592903137},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5462157726287842},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.5416342616081238},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5306887626647949},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.48261651396751404},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4506525993347168},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44011932611465454},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4158768653869629},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.39731618762016296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38473108410835266},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13834190368652344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12952053546905518}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20819569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20819569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:3146424026","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/201014/34697810.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null},{"id":"mag:9594690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20819569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2057304478","https://openalex.org/W2105359661","https://openalex.org/W2414848279","https://openalex.org/W2091802637"],"related_works":["https://openalex.org/W2040320125","https://openalex.org/W2022889334","https://openalex.org/W1984964878","https://openalex.org/W3031169201","https://openalex.org/W2584919767","https://openalex.org/W2075399644","https://openalex.org/W1902208672","https://openalex.org/W2027250414","https://openalex.org/W3113027002","https://openalex.org/W3021169299"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alzheimer's":[1],"disease":[2],"(AD)":[3],"is":[4,34,50],"a":[5,287],"neurodegenerative":[6],"disorder":[7],"and":[8,29,65,71,83,111,143,153,168,181,189,194,208,210,231,255,269,280],"the":[9,15,37,46,61,73,78,86,148,151,154,197,236,240,249,291,297],"leading":[10],"cause":[11],"of":[12,26,36,40,48,55,75,80,88,150,223,229,239,251,293],"dementia":[13],"in":[14,21,45,85,196,235,272,290,296],"elderly.":[16],"The":[17,53,161],"two":[18],"hallmark":[19],"lesions":[20],"AD":[22,49],"brain":[23,174,198],"are":[24],"deposition":[25],"amyloid":[27],"plaques":[28],"neurofibrillary":[30],"tangles":[31],"(NFTs).":[32],"Hypercholesteremia":[33,264],"one":[35],"risk":[38],"factors":[39],"AD.":[41],"But":[42],"its":[43],"role":[44,289],"pathogenesis":[47],"largely":[51],"unknown.":[52],"aim":[54],"this":[56],"study":[57],"was":[58,130],"to":[59,132,221],"investigate":[60],"relationship":[62],"between":[63],"hypercholesteremia":[64,222],"tau":[66,81,230,253,267,278],"phosphorylation":[67,82,193,254],"or":[68],"beta-amyloid":[69],"(Abeta),":[70],"evaluate":[72],"effect":[74],"atorvastatin":[76,116,247],"on":[77],"level":[79,234,257],"Abeta":[84,195,233,256,270,282],"brains":[87,169],"rats":[89,98,224,245],"fed":[90,244],"with":[91,246],"high":[92,107,112,217,241,260],"cholesterol":[93,108,113,135,218,242,261],"diet.":[94,262],"METHODS:":[95],"Sprague-Dawley":[96],"(SD)":[97],"were":[99,163,170,176,184,200],"randomly":[100],"divided":[101],"into":[102],"normal":[103],"diet":[104,109,114,219,243],"control":[105],"group,":[106,110],"plus":[115],"(Lipitor,":[117],"15":[118],"mg":[119],"x":[120,122],"kg(-1)":[121],"d(-1))":[123],"treated":[124],"group.":[125],"Blood":[126],"from":[127,186],"caudal":[128],"vein":[129],"collected":[131],"measure":[133],"total":[134],"(TC),":[136],"triglyceride":[137],"(TG),":[138],"low":[139],"density":[140],"lipoprotein":[141,145],"(LDL)":[142],"high-density":[144],"(HDL)":[146],"at":[147],"end":[149],"3rd":[152],"6th":[155],"months":[156,166],"by":[157,202,259],"an":[158],"enzymatic":[159],"method.":[160],"animals":[162],"sacrificed":[164],"6":[165],"later":[167],"removed.":[171],"All":[172],"left":[173],"hemispheres":[175,188],"fixed":[177],"for":[178],"immunohistochemistry.":[179],"Hippocampus":[180],"cerebral":[182],"cortex":[183],"separated":[185],"right":[187],"homogenized":[190],"separately.":[191],"Tau":[192],"tissue":[199],"determined":[201],"Western":[203],"blotting":[204],"(using":[205],"antibodies":[206],"PHF-1":[207],"Tau-1)":[209],"anti-Abeta40/anti-Abeta42,":[211],"respectively.":[212],"RESULTS:":[213],"We":[214],"found":[215],"that":[216],"led":[220],"as":[225,227],"well":[226],"hyperphosphorylation":[228,268,279],"increased":[232],"brains.":[237],"Treatment":[238],"prevented":[248],"changes":[250],"both":[252],"induced":[258],"CONCLUSIONS:":[263],"could":[265,276],"induce":[266],"production":[271],"rat":[273],"brain.":[274,298],"Atorvastatin":[275],"inhibit":[277],"decrease":[281],"generation.":[283],"It":[284],"may":[285],"play":[286],"protective":[288],"patho-process":[292],"hypercholesteremia-induced":[294],"neurodegeneration":[295]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
