{"id":"https://openalex.org/W95839151","doi":"https://doi.org/10.4049/jimmunol.178.supp.49.11","title":"A novel role of myeloid related protein in dendritic cell differentiation (49.11)","display_name":"A novel role of myeloid related protein in dendritic cell differentiation (49.11)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W95839151","doi":"https://doi.org/10.4049/jimmunol.178.supp.49.11","mag":"95839151"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.49.11","doi":"https://doi.org/10.4049/jimmunol.178.supp.49.11","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.49.11","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052521597","display_name":"Pingyan Cheng","orcid":"https://orcid.org/0009-0003-0205-1418","observed_orcids":["https://orcid.org/0009-0003-0205-1418"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingyan Cheng","raw_affiliation_strings":["Immunology, H Lee Moffitt Cancer Center,University of South Florida , 12902 Magnolia Dr, Tampa, FL, 33612","1Immunology, H Lee Moffitt Cancer Center,University of South Florida, 12902 Magnolia Dr, Tampa, FL, 33612,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, H Lee Moffitt Cancer Center,University of South Florida , 12902 Magnolia Dr, Tampa, FL, 33612","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]},{"raw_affiliation_string":"1Immunology, H Lee Moffitt Cancer Center,University of South Florida, 12902 Magnolia Dr, Tampa, FL, 33612,","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021788436","display_name":"Bin Yu","orcid":"https://orcid.org/0000-0002-7207-643X","observed_orcids":["https://orcid.org/0000-0002-7207-643X","https://orcid.org/0009-0007-0671-5380"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Yu","raw_affiliation_strings":["Immunology, H Lee Moffitt Cancer Center,University of South Florida , 12902 Magnolia Dr, Tampa, FL, 33612","1Immunology, H Lee Moffitt Cancer Center,University of South Florida, 12902 Magnolia Dr, Tampa, FL, 33612,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, H Lee Moffitt Cancer Center,University of South Florida , 12902 Magnolia Dr, Tampa, FL, 33612","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]},{"raw_affiliation_string":"1Immunology, H Lee Moffitt Cancer Center,University of South Florida, 12902 Magnolia Dr, Tampa, FL, 33612,","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111796638","display_name":"Sorena Nadaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sorena Nadaf","raw_affiliation_strings":["The Vanderbilt Cancer Center, Vanderbilt University , 685 Preston Research Building, Nashville, TN, 37232-6838","2The Vanderbilt Cancer Center, Vanderbilt University, 685 Preston Research Building, Nashville, TN, 37232-6838,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt Cancer Center, Vanderbilt University , 685 Preston Research Building, Nashville, TN, 37232-6838","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"2The Vanderbilt Cancer Center, Vanderbilt University, 685 Preston Research Building, Nashville, TN, 37232-6838,","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059652753","display_name":"David Paul Carbone","orcid":"https://orcid.org/0000-0003-3002-1921","observed_orcids":["https://orcid.org/0000-0003-3002-1921"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P Carbone","raw_affiliation_strings":["The Vanderbilt Cancer Center, Vanderbilt University , 685 Preston Research Building, Nashville, TN, 37232-6838","2The Vanderbilt Cancer Center, Vanderbilt University, 685 Preston Research Building, Nashville, TN, 37232-6838,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt Cancer Center, Vanderbilt University , 685 Preston Research Building, Nashville, TN, 37232-6838","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"2The Vanderbilt Cancer Center, Vanderbilt University, 685 Preston Research Building, Nashville, TN, 37232-6838,","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063490767","display_name":"Wolfgang K. F. Nacken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Nacken","raw_affiliation_strings":["Institute for Experimental Dermatology, University of Muenster , Roentgenstr. 21, Muenster, 48149 ,","3Institute for Experimental Dermatology, University of Muenster, Roentgenstr. 21, Muenster, 48149, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Dermatology, University of Muenster , Roentgenstr. 21, Muenster, 48149 ,","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"3Institute for Experimental Dermatology, University of Muenster, Roentgenstr. 21, Muenster, 48149, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063221820","display_name":"Clemens Sorg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clemens Sorg","raw_affiliation_strings":["Institute for Experimental Dermatology, University of Muenster , Roentgenstr. 21, Muenster, 48149 ,","3Institute for Experimental Dermatology, University of Muenster, Roentgenstr. 21, Muenster, 48149, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Dermatology, University of Muenster , Roentgenstr. 21, Muenster, 48149 ,","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"3Institute for Experimental Dermatology, University of Muenster, Roentgenstr. 21, Muenster, 48149, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041091140","display_name":"Dmitry I. Gabrilovich","orcid":"https://orcid.org/0000-0001-9913-6407","observed_orcids":["https://orcid.org/0000-0001-9913-6407"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry I Gabrilovich","raw_affiliation_strings":["Immunology, H Lee Moffitt Cancer Center,University of South Florida , 12902 Magnolia Dr, Tampa, FL, 33612","1Immunology, H Lee Moffitt Cancer Center,University of South Florida, 12902 Magnolia Dr, Tampa, FL, 33612,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, H Lee Moffitt Cancer Center,University of South Florida , 12902 Magnolia Dr, Tampa, FL, 33612","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]},{"raw_affiliation_string":"1Immunology, H Lee Moffitt Cancer Center,University of South Florida, 12902 Magnolia Dr, Tampa, FL, 33612,","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"S85","last_page":"S85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.41359999775886536,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.859000027179718},{"id":"https://openalex.org/keywords/dendritic-cell-differentiation","display_name":"dendritic cell differentiation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immature-myeloid-cells","display_name":"immature myeloid cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.621999979019165},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.8209311962127686},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5494297742843628},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5438677668571472},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5105751752853394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5057663917541504},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5006306171417236},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.48536837100982666},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4544958174228668},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4320942759513855},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4031206965446472},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37976109981536865},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2695711553096771},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09286037087440491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08821126818656921}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.49.11","doi":"https://doi.org/10.4049/jimmunol.178.supp.49.11","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.49.11","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993340690","https://openalex.org/W2049929103","https://openalex.org/W4312210209","https://openalex.org/W3025380884","https://openalex.org/W2142721824","https://openalex.org/W2166953517","https://openalex.org/W2532453284","https://openalex.org/W2662893324","https://openalex.org/W2341797777","https://openalex.org/W2559256307"],"abstract_inverted_index":{"Abstract":[0],"Abnormal":[1],"differentiation":[2,33,63,99,130],"of":[3,42,69,73,83,87,97,102,134,151,158,166,179,190,202],"dendritic":[4],"cell":[5],"(DC)":[6],"is":[7,112],"a":[8,198],"critical":[9],"factor":[10],"contributing":[11],"into":[12,28],"ineffective":[13],"immune":[14],"response":[15],"in":[16,31,52,90,95,122,127,131,141,148,181,205,208],"cancer.":[17,182,209],"We":[18,137],"have":[19,138],"searched":[20],"for":[21,177],"the":[22,132],"genes":[23],"that":[24,36,114,140,171,187],"could":[25],"be":[26],"involved":[27],"tumor-induced":[29,188,203],"defects":[30],"DC":[32,59,62,98,129,193],"and":[34,48,55,100,125],"found":[35,139],"tumor-derived":[37,135],"factors":[38],"consistently":[39],"up-regulated":[40],"expression":[41],"myeloid":[43,56,75,104,109,206],"related":[44],"protein":[45],"14":[46],"(MRP14)":[47],"its":[49],"partner":[50],"MRP8":[51],"hematopoietic":[53],"progenitor":[54],"cells":[57,76,93,105,118,207],"during":[58,126],"differentiation.":[60],"Normal":[61],"was":[64,77,154],"associated":[65,78],"with":[66,79],"dramatic":[67],"down-regulation":[68],"MRP14/8,":[70],"whereas":[71],"accumulation":[72,101,178],"immature":[74,103],"persistently":[80],"high":[81],"levels":[82],"these":[84,88,152],"proteins.":[85],"Overexpression":[86],"proteins":[89,153,173],"embryonic":[91],"stem":[92],"resulted":[94],"inhibition":[96],"able":[106],"to":[107],"form":[108],"colonies.":[110],"It":[111],"known":[113],"Gr-1+":[115],"myeloid-derived":[116],"suppressor":[117],"(MDSC)":[119],"frequently":[120],"accumulate":[121],"tumor-bearing":[123,142],"mice":[124,143,162],"vitro":[128],"presence":[133],"factors.":[136],"MRP14/8":[144,160],"were":[145,174],"exclusively":[146],"accumulated":[147],"MDSC.":[149],"Accumulation":[150],"controlled":[155],"by":[156],"up-regulation":[157,189],"STAT3.":[159],"knockout":[161],"had":[163],"normal":[164],"level":[165],"DCs":[167],"or":[168],"MDSC":[169,180],"suggesting":[170],"MRP":[172],"not":[175],"required":[176],"Thus,":[183],"this":[184],"study":[185],"demonstrates":[186],"MRPs":[191],"inhibits":[192],"differentiation,":[194],"which":[195],"may":[196],"suggest":[197],"novel":[199],"molecular":[200],"mechanism":[201],"abnormalities":[204]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}