{"id":"https://openalex.org/W95696771","doi":null,"title":"Genetic studies in the rheumatic diseases: present status and implications for the future.","display_name":"Genetic studies in the rheumatic diseases: present status and implications for the future.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W95696771","mag":"95696771","pmid":"https://pubmed.ncbi.nlm.nih.gov/15660456"},"language":"en","primary_location":{"id":"pmid:15660456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15660456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066883334","display_name":"John D. Reveille","orcid":"https://orcid.org/0000-0001-5950-0913","observed_orcids":["https://orcid.org/0000-0001-5950-0913"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John D Reveille","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunogenetics, University of Texas-Houston Health Science Ctr., Houston, Texas 77030, USA. john.reveille@uth.tmc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunogenetics, University of Texas-Houston Health Science Ctr., Houston, Texas 77030, USA. john.reveille@uth.tmc.edu","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066883334"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":null,"apc_paid":null,"fwci":2.4509,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.88848021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"72","issue":null,"first_page":"10","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.33079999685287476,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0908999964594841,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatic-diseases","display_name":"rheumatic diseases","score":0.9739999771118164},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":1.0},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hla-dr4","display_name":"HLA-DR4","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hla-b27","display_name":"HLA-B27","score":1.0},{"id":"https://openalex.org/keywords/hla-drb1","display_name":"HLA-DRB1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/c4-null-alleles","display_name":"C4 null alleles","score":0.871999979019165},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.5950000286102295},{"id":"https://openalex.org/keywords/fcgr2a","display_name":"FCGR2A","score":0.7250000238418579},{"id":"https://openalex.org/keywords/fcgammariiia","display_name":"Fc\u03b3RIIIa","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fibrillin","display_name":"fibrillin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sparc","display_name":"SPARC","score":0.9860000014305115},{"id":"https://openalex.org/keywords/familial-aggregation","display_name":"familial aggregation","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8057476282119751},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5978557467460632},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5689870119094849},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.5224775075912476},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4990699291229248},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4838513433933258},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4565649926662445},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42725950479507446},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41394904255867004},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36450690031051636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3294227123260498},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20147669315338135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10060721635818481},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.0782599151134491}],"mesh":[{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007391","descriptor_name":"International Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012219","descriptor_name":"Rheumatology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15660456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15660456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology. Supplement","raw_type":"Journal Article"},{"id":"mag:95696771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15660456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2625187507","display_name":"FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITIS","funder_award_id":"R01AR046208","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5249054556","display_name":"General Clinical Research Center","funder_award_id":"M01RR002558","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1970533668","https://openalex.org/W1982772265","https://openalex.org/W1988331425","https://openalex.org/W1996674092","https://openalex.org/W2001620383","https://openalex.org/W2006180796","https://openalex.org/W2013405032","https://openalex.org/W2015638788","https://openalex.org/W2019597863","https://openalex.org/W2035249926","https://openalex.org/W2040656515","https://openalex.org/W2049872934","https://openalex.org/W2161884331","https://openalex.org/W2169636411","https://openalex.org/W2170169633","https://openalex.org/W2337699004","https://openalex.org/W2607741101"],"related_works":["https://openalex.org/W4239021746","https://openalex.org/W2087907159","https://openalex.org/W2619784855","https://openalex.org/W2319479723","https://openalex.org/W1905362077","https://openalex.org/W2043613858","https://openalex.org/W1987055888","https://openalex.org/W2030591333","https://openalex.org/W2079995796","https://openalex.org/W2052564007"],"abstract_inverted_index":{"Recent":[0],"breakthroughs":[1],"in":[2,22,54,81,89,94,106,112,114,134,169,179],"genetic":[3,48],"methodology":[4],"have":[5,77,86,128],"greatly":[6],"augmented":[7],"our":[8],"understanding":[9],"of":[10,13,46,172],"the":[11,18,47,55,119,160],"contribution":[12,49],"genetics":[14],"to":[15,17,50,155,159],"susceptibility":[16],"rheumatic":[19],"diseases.":[20],"Disorders":[21],"which":[23,163],"familial":[24],"aggregation":[25],"has":[26,103],"been":[27,87,104,129],"best":[28],"documented":[29],"include":[30],"rheumatoid":[31],"arthritis":[32],"(RA),":[33,59],"ankylosing":[34],"spondylitis":[35],"(AS),":[36,61],"systemic":[37,42],"lupus":[38],"erythematosus":[39],"(SLE),":[40,69],"and":[41,65,70,72,96,123,133,137],"sclerosis":[43],"(SSc).":[44,74],"Much":[45],"these":[51,157],"diseases":[52],"lies":[53],"MHC,":[56],"including":[57],"HLA-DR4":[58],"HLA-B27":[60],"HLA-DRB1*0301,":[62],"DRB1*1501/*1503,":[63],"DRB1*08,":[64],"C4":[66],"null":[67],"alleles":[68],"HLA-DRB1*11":[71],"DRB1*1502":[73],"Genome-wide":[75],"scans":[76,90],"provided":[78],"inconsistent":[79],"data":[80],"RA,":[82],"although":[83],"consistent":[84,99],"regions":[85],"observed":[88],"from":[91],"different":[92],"groups":[93],"AS":[95,113],"SLE.":[97],"No":[98],"non-MHC":[100],"candidate":[101],"gene":[102],"identified":[105],"RA.":[107],"There":[108],"is":[109],"active":[110],"investigation":[111],"this":[115],"area.":[116],"In":[117],"SLE":[118],"Fc":[120,124],"gamma":[121,125],"RIIa":[122],"IIIa":[126],"genes":[127],"most":[130],"thoroughly":[131],"described,":[132],"SSc":[135],"fibrillin":[136],"SPARC.":[138],"Newer":[139],"techniques":[140],"being":[141],"developed":[142],"presently,":[143],"such":[144],"as":[145],"high":[146],"density":[147],"single":[148],"nucleotide":[149],"polymorphism":[150],"genome-wide":[151],"scanning,":[152],"show":[153],"promise":[154],"bring":[156],"analyses":[158],"next":[161],"level,":[162],"will":[164],"hopefully":[165],"result":[166],"not":[167],"only":[168],"better":[170],"screening":[171],"individuals":[173],"at":[174],"highest":[175],"risk,":[176],"but":[177],"also":[178],"novel":[180],"treatments.":[181]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}