{"id":"https://openalex.org/W956122872","doi":null,"title":"Heparanase\u20131 Unlocks the Lacritin Binding Site on Co\u2013Receptor Syndecan\u20131 as a Prerequisite for Subconfluent Ductal Proliferation","display_name":"Heparanase\u20131 Unlocks the Lacritin Binding Site on Co\u2013Receptor Syndecan\u20131 as a Prerequisite for Subconfluent Ductal Proliferation","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W956122872","mag":"956122872"},"language":"en","primary_location":{"id":"mag:956122872","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2391810","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082470401","display_name":"Peisong Ma","orcid":"https://orcid.org/0000-0002-5486-8695","observed_orcids":["https://orcid.org/0000-0002-5486-8695"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peisong Ma","raw_affiliation_strings":["Department of Cell Biology, University of Virginia, Charlottesville, VA"],"raw_orcid":"https://orcid.org/0000-0002-5486-8695","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052720456","display_name":"SL Beck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SL Beck","raw_affiliation_strings":["Department of Cell Biology, University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009134181","display_name":"Ronald W. Raab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11883440","display_name":"James Madison University","ror":"https://ror.org/028pmsz77","country_code":"US","type":"education","lineage":["https://openalex.org/I11883440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald W. Raab","raw_affiliation_strings":["James Madison University, Harrisonburg, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Madison University, Harrisonburg, VA","institution_ids":["https://openalex.org/I11883440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112327058","display_name":"R. McKown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11883440","display_name":"James Madison University","ror":"https://ror.org/028pmsz77","country_code":"US","type":"education","lineage":["https://openalex.org/I11883440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. McKown","raw_affiliation_strings":["James Madison University, Harrisonburg, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Madison University, Harrisonburg, VA","institution_ids":["https://openalex.org/I11883440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009070630","display_name":"George L. Coffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11883440","display_name":"James Madison University","ror":"https://ror.org/028pmsz77","country_code":"US","type":"education","lineage":["https://openalex.org/I11883440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George L. Coffman","raw_affiliation_strings":["James Madison University, Harrisonburg, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Madison University, Harrisonburg, VA","institution_ids":["https://openalex.org/I11883440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084124992","display_name":"Alan C. Rapraeger","orcid":"https://orcid.org/0000-0003-1719-3286","observed_orcids":["https://orcid.org/0000-0003-1719-3286"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan C. Rapraeger","raw_affiliation_strings":["University of Wisconsin, Madison Madison, WI"],"raw_orcid":"https://orcid.org/0000-0003-1719-3286","affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073294634","display_name":"Gordon W. Laurie","orcid":"https://orcid.org/0000-0002-5311-2650","observed_orcids":["https://orcid.org/0000-0002-5311-2650"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon W. Laurie","raw_affiliation_strings":["Department of Cell Biology, University of Virginia, Charlottesville, VA"],"raw_orcid":"https://orcid.org/0000-0002-5311-2650","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08865827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"13","first_page":"1953","last_page":"1953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparanase","display_name":"heparanase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lacritin","display_name":"lacritin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/co-receptors","display_name":"co-receptors","score":0.5460000038146973},{"id":"https://openalex.org/keywords/lacrimal-gland","display_name":"lacrimal gland","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lacrimal-ducts","display_name":"lacrimal ducts","score":0.4189999997615814},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2777478136","wikidata":"https://www.wikidata.org/wiki/Q909646","display_name":"Heparanase","level":4,"score":0.7160235643386841},{"id":"https://openalex.org/C65001120","wikidata":"https://www.wikidata.org/wiki/Q14912913","display_name":"Syndecan 1","level":3,"score":0.587787389755249},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44514697790145874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37107476592063904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.356428325176239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34410372376441956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3342141807079315},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25273025035858154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1852063238620758},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.12043598294258118},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.08682167530059814},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.05138826370239258}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:956122872","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2391810","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4255962332","https://openalex.org/W7096409187","https://openalex.org/W2318428566","https://openalex.org/W2118677410","https://openalex.org/W768179963","https://openalex.org/W2992308143","https://openalex.org/W7019065742","https://openalex.org/W2993368184","https://openalex.org/W7000982481","https://openalex.org/W1209421744"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}