{"id":"https://openalex.org/W95356262","doi":null,"title":"Modifications of the Staphylococcus aureus cell envelope and their roles in host-microbe interactions","display_name":"Modifications of the Staphylococcus aureus cell envelope and their roles in host-microbe interactions","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W95356262","mag":"95356262"},"language":"en","primary_location":{"id":"mag:95356262","doi":null,"is_oa":false,"landing_page_url":"https://publikationen.uni-tuebingen.de/xmlui/bitstream/handle/10900/49117/pdf/Dissertation_Dirk_Kraus_2007.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111907049","display_name":"Dirk Kraus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dirk Kraus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111907049"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.15929999947547913,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/muramyl-dipeptide","display_name":"muramyl dipeptide","score":0.878000020980835},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.7820000052452087},{"id":"https://openalex.org/keywords/proinflammatory-effects","display_name":"pro-inflammatory effects","score":0.796999990940094},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-envelope","display_name":"cell envelope","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.9563027620315552},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8508574962615967},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8375639319419861},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7292656898498535},{"id":"https://openalex.org/C46371251","wikidata":"https://www.wikidata.org/wiki/Q4886486","display_name":"Cell envelope","level":4,"score":0.6945689916610718},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5070705413818359},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4492189586162567},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4444364309310913},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.44050663709640503},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43092668056488037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.420888751745224},{"id":"https://openalex.org/C2778253522","wikidata":"https://www.wikidata.org/wiki/Q899834","display_name":"Teichoic acid","level":4,"score":0.4200690984725952},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3683542013168335},{"id":"https://openalex.org/C125235067","wikidata":"https://www.wikidata.org/wiki/Q128700","display_name":"Cell wall","level":2,"score":0.34185752272605896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23291057348251343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22937926650047302},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.16654881834983826},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14621815085411072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11682593822479248},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1051507294178009},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:95356262","doi":null,"is_oa":false,"landing_page_url":"https://publikationen.uni-tuebingen.de/xmlui/bitstream/handle/10900/49117/pdf/Dissertation_Dirk_Kraus_2007.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":168,"referenced_works":["https://openalex.org/W63034058","https://openalex.org/W146249449","https://openalex.org/W191975612","https://openalex.org/W1485348851","https://openalex.org/W1497351261","https://openalex.org/W1519633296","https://openalex.org/W1540464676","https://openalex.org/W1542741488","https://openalex.org/W1546022138","https://openalex.org/W1567198647","https://openalex.org/W1578768687","https://openalex.org/W1580496446","https://openalex.org/W1587411894","https://openalex.org/W1612814855","https://openalex.org/W1775706358","https://openalex.org/W1783885505","https://openalex.org/W1873518711","https://openalex.org/W1896469456","https://openalex.org/W1897355343","https://openalex.org/W1952842430","https://openalex.org/W1964758221","https://openalex.org/W1965614061","https://openalex.org/W1966479702","https://openalex.org/W1973976196","https://openalex.org/W1976222462","https://openalex.org/W1976666632","https://openalex.org/W1978805458","https://openalex.org/W1979751791","https://openalex.org/W1979932265","https://openalex.org/W1980110907","https://openalex.org/W1981025988","https://openalex.org/W1981057559","https://openalex.org/W1983469188","https://openalex.org/W1984810266","https://openalex.org/W1984936173","https://openalex.org/W1986136996","https://openalex.org/W1987287925","https://openalex.org/W1987362415","https://openalex.org/W1989998611","https://openalex.org/W1990046762","https://openalex.org/W1992216729","https://openalex.org/W1992645380","https://openalex.org/W1994737052","https://openalex.org/W1994941496","https://openalex.org/W1995653973","https://openalex.org/W1997152791","https://openalex.org/W2000563070","https://openalex.org/W2002218478","https://openalex.org/W2003112779","https://openalex.org/W2003634035","https://openalex.org/W2004274040","https://openalex.org/W2008152503","https://openalex.org/W2008349272","https://openalex.org/W2008390343","https://openalex.org/W2011385850","https://openalex.org/W2015115693","https://openalex.org/W2016723679","https://openalex.org/W2019275072","https://openalex.org/W2019544986","https://openalex.org/W2026220836","https://openalex.org/W2028176310","https://openalex.org/W2029650876","https://openalex.org/W2031458021","https://openalex.org/W2033689625","https://openalex.org/W2034541624","https://openalex.org/W2035158221","https://openalex.org/W2037541009","https://openalex.org/W2038143978","https://openalex.org/W2040024879","https://openalex.org/W2043218808","https://openalex.org/W2044562813","https://openalex.org/W2049352189","https://openalex.org/W2052140557","https://openalex.org/W2056618449","https://openalex.org/W2057198053","https://openalex.org/W2060382263","https://openalex.org/W2061129149","https://openalex.org/W2061514792","https://openalex.org/W2063177628","https://openalex.org/W2064512828","https://openalex.org/W2065797880","https://openalex.org/W2067164351","https://openalex.org/W2069663822","https://openalex.org/W2069981713","https://openalex.org/W2071572118","https://openalex.org/W2072255703","https://openalex.org/W2072547768","https://openalex.org/W2074692187","https://openalex.org/W2075583035","https://openalex.org/W2077027868","https://openalex.org/W2079281658","https://openalex.org/W2079605309","https://openalex.org/W2080267955","https://openalex.org/W2080857291","https://openalex.org/W2083039164","https://openalex.org/W2084849766","https://openalex.org/W2090975158","https://openalex.org/W2091813080","https://openalex.org/W2094741750","https://openalex.org/W2095179527","https://openalex.org/W2098499925","https://openalex.org/W2098786490","https://openalex.org/W2100069569","https://openalex.org/W2100924623","https://openalex.org/W2101182659","https://openalex.org/W2103688851","https://openalex.org/W2104455358","https://openalex.org/W2108174511","https://openalex.org/W2111154143","https://openalex.org/W2111900042","https://openalex.org/W2112311560","https://openalex.org/W2112580008","https://openalex.org/W2113031999","https://openalex.org/W2113410040","https://openalex.org/W2114877531","https://openalex.org/W2115976076","https://openalex.org/W2116056037","https://openalex.org/W2119768770","https://openalex.org/W2122803099","https://openalex.org/W2124381039","https://openalex.org/W2125309974","https://openalex.org/W2130143969","https://openalex.org/W2130534359","https://openalex.org/W2132417094","https://openalex.org/W2132721418","https://openalex.org/W2133219213","https://openalex.org/W2133838892","https://openalex.org/W2134284130","https://openalex.org/W2135563180","https://openalex.org/W2135918794","https://openalex.org/W2136051934","https://openalex.org/W2137081432","https://openalex.org/W2139215655","https://openalex.org/W2140166790","https://openalex.org/W2140452348","https://openalex.org/W2140845434","https://openalex.org/W2141526752","https://openalex.org/W2141676495","https://openalex.org/W2142703076","https://openalex.org/W2143996485","https://openalex.org/W2147376478","https://openalex.org/W2148128286","https://openalex.org/W2148347746","https://openalex.org/W2148579227","https://openalex.org/W2149119766","https://openalex.org/W2151669381","https://openalex.org/W2152432564","https://openalex.org/W2153245687","https://openalex.org/W2153972223","https://openalex.org/W2156172406","https://openalex.org/W2160170449","https://openalex.org/W2161587331","https://openalex.org/W2163451578","https://openalex.org/W2164851792","https://openalex.org/W2166791780","https://openalex.org/W2167573728","https://openalex.org/W2167665502","https://openalex.org/W2168638566","https://openalex.org/W2169748146","https://openalex.org/W2170113031","https://openalex.org/W2170267077","https://openalex.org/W2170367123","https://openalex.org/W2170540001","https://openalex.org/W2171061708","https://openalex.org/W2171289671","https://openalex.org/W2236107045","https://openalex.org/W2314649741","https://openalex.org/W2327388154"],"related_works":["https://openalex.org/W2140166790","https://openalex.org/W2875814301","https://openalex.org/W193504920","https://openalex.org/W2088273079","https://openalex.org/W6983779167","https://openalex.org/W1967663562","https://openalex.org/W7163866953","https://openalex.org/W2966293722","https://openalex.org/W7122833392","https://openalex.org/W2032819924"],"abstract_inverted_index":{"Peptidoglycan":[0],"muropeptides,":[1],"potent":[2],"proinflammatory":[3,20],"components,":[4],"are":[5],"amidated":[6],"in":[7],"Staphylococcus":[8],"aureus":[9,27],"for":[10,61],"unknown":[11],"reasons.":[12],"To":[13],"study":[14],"whether":[15],"this":[16],"modification":[17],"may":[18],"modulate":[19],"capacity,":[21],"cytokine":[22,46],"induction":[23],"by":[24,34],"isogenic":[25],"S.":[26],"strains":[28],"with":[29],"different":[30],"amidation":[31,41,63],"levels":[32],"and":[33,56],"synthetic":[35],"amidated/nonamidated":[36],"muramyldipeptides":[37],"was":[38],"evaluated.":[39],"However,":[40],"did":[42],"not":[43],"significantly":[44],"affect":[45],"induction.":[47],"This":[48],"finding":[49],"contributes":[50],"to":[51,65],"defining":[52],"peptidoglycan":[53],"receptor":[54],"specificities":[55],"indicates":[57],"that":[58],"further":[59],"rationales":[60],"muropeptide":[62],"have":[64],"be":[66],"considered.":[67]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}