{"id":"https://openalex.org/W95353010","doi":null,"title":"The role of alpha-atrial natriuretic peptide in fluid retention during mechanical ventilation with positive end-expiratory pressure.","display_name":"The role of alpha-atrial natriuretic peptide in fluid retention during mechanical ventilation with positive end-expiratory pressure.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W95353010","mag":"95353010","pmid":"https://pubmed.ncbi.nlm.nih.gov/2948066"},"language":"en","primary_location":{"id":"pmid:2948066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2948066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006547876","display_name":"Richard Pacher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Pacher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029911477","display_name":"Michael Frass","orcid":"https://orcid.org/0000-0003-4140-4258","observed_orcids":["https://orcid.org/0000-0003-4140-4258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Frass","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110076516","display_name":"E Hartter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Hartter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110095474","display_name":"Wolfgang Woloszczuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Woloszczuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113589018","display_name":"C Leithner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Leithner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0754,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.74790757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"64 Suppl 6","issue":null,"first_page":"64","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluid-retention","display_name":"fluid retention","score":0.8920000195503235},{"id":"https://openalex.org/keywords/positive-end-expiratory-pressure","display_name":"positive end-expiratory pressure","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/acute-respiratory-failure","display_name":"acute respiratory failure","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasma-anp-levels","display_name":"plasma ANP levels","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cardiac-index","display_name":"cardiac index","score":0.7760000228881836},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.8700000047683716},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.7739999890327454},{"id":"https://openalex.org/keywords/venous-return","display_name":"venous return","score":0.6819999814033508},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.8339999914169312},{"id":"https://openalex.org/keywords/baroreceptors","display_name":"baroreceptors","score":0.6349999904632568},{"id":"https://openalex.org/keywords/volume-expansion","display_name":"volume expansion","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.7091554403305054},{"id":"https://openalex.org/C2778917391","wikidata":"https://www.wikidata.org/wiki/Q352381","display_name":"Positive end-expiratory pressure","level":3,"score":0.6701703667640686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6592427492141724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6354760527610779},{"id":"https://openalex.org/C35207712","wikidata":"https://www.wikidata.org/wiki/Q190402","display_name":"Central venous pressure","level":4,"score":0.5373393893241882},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5039648413658142},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4888598322868347},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.45272424817085266},{"id":"https://openalex.org/C2910216633","wikidata":"https://www.wikidata.org/wiki/Q745438","display_name":"Inferior vena cava","level":2,"score":0.44663378596305847},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4415293335914612},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.42719531059265137},{"id":"https://openalex.org/C47323905","wikidata":"https://www.wikidata.org/wiki/Q3506185","display_name":"Venous return curve","level":3,"score":0.4193102717399597},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3773306906223297},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3652503788471222},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.3075393736362457},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2548692226409912}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014883","descriptor_name":"Water-Electrolyte Imbalance","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014883","descriptor_name":"Water-Electrolyte Imbalance","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2948066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2948066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Wochenschrift","raw_type":"Journal Article"},{"id":"mag:95353010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2948066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050103638","https://openalex.org/W1985454213","https://openalex.org/W2133774108","https://openalex.org/W1986955817","https://openalex.org/W2089700175","https://openalex.org/W2061169133","https://openalex.org/W2168549210","https://openalex.org/W2091063469","https://openalex.org/W2091302044","https://openalex.org/W2068810226"],"abstract_inverted_index":{"Although":[0],"controlled":[1],"mechanical":[2],"ventilation":[3],"(CMV)":[4],"with":[5,33,110,148,172,217],"positive":[6],"end-expiratory":[7],"pressure":[8],"(PEEP)":[9],"has":[10],"a":[11,63,149,237],"central":[12],"place":[13],"in":[14,66,84,89,108,119,126,144,151,163,187,222,230,247,253],"the":[15,57,67,185,196,200,207,220,248],"treatment":[16],"of":[17,25,40,44,69,82,122,180,189,203,233,239,241],"acute":[18],"respiratory":[19],"failure":[20],"(ARF),":[21],"several":[22],"side":[23],"effects":[24],"this":[26],"technique":[27],"have":[28],"to":[29,78,176,206],"be":[30,192],"faced.":[31],"CMV":[32,171,216],"PEEP":[34,103,111,173,218],"may":[35,191],"induce":[36],"pulmonary":[37,135],"barotrauma,":[38],"disturbance":[39],"cardiac":[41,152,223],"performance,":[42],"impairment":[43],"renal":[45],"function":[46],"and":[47,61,71,137,158,199,225,236,251,255],"fluid":[48,72,213],"retention.":[49],"Atrial":[50],"natriuretic":[51],"peptides":[52],"(ANP)":[53],"are":[54,219],"released":[55],"from":[56,93,129],"atria":[58],"upon":[59],"stretching":[60],"play":[62],"major":[64],"role":[65],"control":[68],"sodium":[70,160],"balance.":[73],"Therefore":[74],"it":[75],"was":[76,124,146],"logical":[77],"determine":[79],"plasma":[80,98,120,178],"levels":[81,99,121,179],"alpha-ANP":[83,97,123,145,190],"CMV.":[85],"A":[86],"study":[87],"performed":[88],"7":[90],"patients":[91],"suffering":[92],"ARF":[94],"suggested":[95],"that":[96,170],"were":[100],"depressed":[101],"during":[102,215],"at":[104,112],"15":[105],"cm":[106,114],"H2O":[107,115],"comparison":[109],"0":[113],"(ZEEP).":[116],"The":[117,142,182],"decrease":[118,143,221],"evident":[125],"samples":[127],"taken":[128],"superior":[130],"vena":[131],"cava,":[132],"right":[133],"atrium,":[134],"artery":[136,139],"radial":[138],"as":[140],"well.":[141],"associated":[147],"decline":[150,186],"index,":[153],"creatinine":[154],"clearance,":[155],"urinary":[156,159],"output":[157],"excretion.":[161],"Experiments":[162],"volume-":[164],"expanded":[165],"healthy":[166],"volunteers":[167],"also":[168],"suggest":[169],"is":[174],"able":[175],"depress":[177],"alpha-ANP.":[181],"reasons":[183],"behind":[184],"release":[188,240],"atrial":[193],"compression":[194],"by":[195],"distended":[197],"lungs":[198],"well-known":[201],"reduction":[202],"venous":[204],"return":[205],"heart.":[208],"Other":[209],"possible":[210],"factors":[211],"promoting":[212],"retention":[214],"index":[224],"glomerular":[226],"filtration":[227],"rate,":[228],"changes":[229],"intrarenal":[231],"distribution":[232],"blood":[234],"flow,":[235],"stimulation":[238],"antidiuretic":[242],"hormone":[243],"via":[244],"stretch":[245],"receptors":[246],"left":[249],"atrium":[250],"baroreceptors":[252],"aorta":[254],"carotid":[256],"arteries.":[257]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}